Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2019). A Meta-analysis of Intervention Effects on Depression and/or Anxiety in Youth Exposed to Political Violence or Natural Disasters. Child and Youth Care Forum
“Background: meta-analyses of youth mass trauma intervention studies have focused primarily on posttraumatic stress even though depression and anxiety are common maladaptive outcomes that require intervention. objective: this meta-analysis examined youth mass trauma intervention effects on depression and anxiety relative to natural recovery and characteristics of the event, context, population, intervention, and intervention delivery that may have moderated these effects. method: a literature search identified 21 studies investigating the effectiveness of 24 randomized controlled trials with inactive controls (21 trials examined depression and 8 examined anxiety; 5 examined both). intervention effects were computed as hedge’s g estimates and combined using random effects models. moderator analysis computed intervention effect sizes across selected covariates. results: the summary intervention effect was not significant for either depression or anxiety. there were statistically significant effects for depression with interventions delivered following a natural disaster (g = 0.40; p = 0.0192) or in a high income country (g = 0.30; p = 0.0253) and with non-trauma-focused interventions (g = 0.29; p = 0.0155) and those delivered in more than eight sessions (g = 0.23; p = 0.0416). the effect for anxiety symptoms was significant only with non-trauma-focused interventions (g = 0.83; p = 0.0428). conclusions: given the prevalence of depression and anxiety post event, greater attention is warranted to develop and maximize the benefit of interventions for these outcomes. the findings suggest that trauma-focused interventions may need to be augmented with specific components directed at depression and/or anxiety.”
Pfefferbaum, B., Noffsinger, M. A., & Wind, L. H.. (2012). Issues in the assessment of Children’s coping in the context of mass trauma. Prehospital and Disaster Medicine
Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2021). A critical review of effective child mass trauma interventions: What we know and do not know from the evidence. Behavioral Sciences
“Over the last 20 years, numerous interventions have been developed and evaluated for use with children exposed to mass trauma with six publications reporting meta-analyses of randomized controlled trials of child mass trauma interventions using inactive controls to examine intervention effects on posttraumatic stress, depression, anxiety, and functional impairment. the current report reviews the results of these meta-analytic studies to examine the status of the evidence for child mass trauma mental health interventions and to evaluate potential moderators of intervention effect and implications for practice. the meta-analyses reviewed for the current report revealed a small to medium overall effect of interventions on posttraumatic stress, a non-statistically significant to small overall effect on depression, a non-statistically significant overall effect on anxiety, and a small overall effect on functional impairment. the subgroup analyses suggest that interventions should be matched to the populations being served and to the context. additional research is needed to tailor future interventions to further address outcomes other than posttraumatic stress including depression, anxiety, and functional impairment.”
Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2020). The Effect of Interventions on Functional Impairment in Youth Exposed to Mass Trauma: a Meta-Analysis. Journal of Child and Adolescent Trauma
“This study examined the benefit of psychosocial interventions on functional impairment in youth exposed to mass trauma. a random effects meta-analysis was used to estimate the overall effect in 15 intervention trials identified through a literature review. the moderator analysis examined how the effect of intervention differed across types of populations receiving the intervention (targeted or non-targeted samples), characteristics of intervention delivery (individual or group application and number of sessions), and the context of intervention administration (country income level). the results revealed a significant small effect on functional impairment (hedges’ g = 0.33; 95%ci = (0.16; 0.50); p = 0.0011). none of the moderators explained the heterogeneity in intervention effect, perhaps due to the small number of trials. the effect of the interventions on functional impairment and on posttraumatic stress were positively correlated. the current analysis provides preliminary evidence that interventions can improve functioning in youth exposed to mass trauma, but the mechanisms, moderators, and duration of benefit are yet unknown.”
Pfefferbaum, B., Nitiéma, P., Newman, E., & Patel, A.. (2019). The Benefit of Interventions to Reduce Posttraumatic Stress in Youth Exposed to Mass Trauma: A Review and Meta-Analysis. Prehospital and Disaster Medicine
“Numerous interventions to address posttraumatic stress (pts) in youth exposed to mass trauma have been delivered and evaluated. it remains unclear, however, which interventions work for whom and under what conditions. this report describes a meta-analysis of the effect of youth mass-trauma interventions on pts to determine if interventions were superior to inactive controls and describes a moderator analysis to examine whether the type of event, population characteristics, or income level of the country where the intervention was delivered may have affected the observed effect sizes. a comprehensive literature search identified randomized controlled trials (rcts) of youth mass-trauma interventions relative to inactive controls. the search identified 2,232 references, of which 25 rcts examining 27 trials (n = 4,662 participants) were included in this meta-analysis. intervention effects were computed as hedge’s g estimates and combined using a random effects model. moderator analyses were conducted to explain the observed heterogeneity among effect sizes using the following independent variables: disaster type (political violence versus natural disaster); sample type (targeted versus non-targeted); and income level of the country where the intervention was delivered (high-versus middle-versus low-income). the correlation between the estimates of the intervention effects on pts and on functional impairment was estimated. the overall treatment effect size was converted into a number needed to treat (nnt) for a practical interpretation. the overall intervention effect was statistically significant (g = 0.57; p <.0001), indicating that interventions had a medium beneficial effect on pts. none of the hypothesized moderators explained the heterogeneity among the intervention effects. estimates of the intervention effects on pts and on functional impairment were positively correlated (spearman’s r = 0.90; p <.0001), indicating a concomitant improvement in both outcomes. these findings confirm that interventions can alleviate pts and enhance functioning in children exposed to mass trauma. this study extends prior research by demonstrating improvement in pts with interventions delivered to targeted and non-targeted populations, regardless of the country income level. intervention populations and available resources should be considered when interpreting the results of intervention studies to inform recommendations for practice.”
Tarvydas, V. M., Levers, L. L., & Teahen, P. R.. (2017). Ethical Guidelines for Mass Trauma and Complex Humanitarian Emergencies. Journal of Counseling and Development
“Issues pertaining to trauma, especially mass trauma and complex humanitarian emergencies, are explored through the lens of ethical counseling guidelines. in mass trauma, particular attention must be paid to the experiences of both survivors and counselors to enhance understanding of ethical best practices and to emphasize the importance of contextual factors in framing effective responses to trauma and humanitarian crises. recommendations regarding ethical guidelines for counseling practice, clinical involvement, and training are offered.”
Pfefferbaum, B., Tucker, P., Nitiéma, P., Van Horn, R. L., Varma, V., Varma, Y., … Newman, E.. (2022). Inconclusive Findings in Studies of the Link Between Media Coverage of Mass Trauma and Depression in Children. Current Psychiatry Reports
“Purpose of review: this paper reports a review of the empirical research examining the association between mass trauma media contact and depression in children, the factors that may influence the association, and the difficulties encountered in the study of media effects on depression. recent findings: all of the included studies assessed general population samples. pre-covid-19 research focused primarily on television coverage alone or on multiple media forms including television, while covid-19 media studies examined various media forms including social media. most studies used cross-sectional design and non-probability sampling. the review revealed inconclusive findings across studies. summary: the study of mass trauma media effects on depression in children is complicated by a number of potential confounding factors and by the relatively high prevalence of depression in the general population. media contact was a relatively minor consideration among other interests in the extant studies which failed to explore numerous issues that warrant attention in future research.”
Meffert, S., & Ekblad, S.. (2013). Global mental health intervention research and mass trauma. Open Access Journal of Clinical Trials
Hobfoll, S. E., Watson, P., Bell, C. C., Bryant, R. A., Brymer, M. J., Friedman, M. J., … Ursano, R. J.. (2007). Five essential elements of immediate and mid-term mass trauma intervention: Empirical evidence. Psychiatry
“Given the devastation caused by disasters and mass violence, it is critical that intervention policy be based on the most updated research findings. however, to date, no evidence-based consensus has been reached supporting a clear set of recommendations for intervention during the immediate and the mid-term post mass trauma phases. because it is unlikely that there will be evidence in the near or mid-term future from clinical trials that cover the diversity of disaster and mass violence circumstances, we assembled a worldwide panel of experts on the study and treatment of those exposed to disaster and mass violence to extrapolate from related fields of research, and to gain consensus on intervention principles. we identified five empirically supported intervention principles that should be used to guide and inform intervention and prevention efforts at the early to mid-term stages. these are promoting: 1) a sense of safety, 2) calming, 3) a sense of self- and community efficacy, 4) connectedness, and 5) hope.”
Husain, M. I., Umer, M., Chaudhry, I. B., Husain, M. O., Rahman, R., Shakoor, S., … Husain, N.. (2021). Relationship between childhood trauma, personality, social support and depression in women attending general medical clinics in a low and middle-income country. Journal of Affective Disorders
“Background: associations between childhood trauma, personality, and major depressive disorder (mdd) have been well established in studies conducted in high-income countries. however, there are limited studies on these associations in low and middle-income countries (lmics), where mdd is highly prevalent. we assessed the relationships between childhood trauma, personality, and mdd in women in karachi, pakistan. method: in this cross-sectional study of 455 female patients attending general medical outpatient clinics, a diagnosis of mdd was confirmed using the structured clinical interview for dsm-iv (scid); retrospective reports of childhood trauma were collected using the childhood trauma questionnaire (ctq); and big five personality traits were assessed using the neo personality inventory revised (neo pi-r). other measures included the life events questionnaire (leq) and the multidimensional scale of perceived social support (mspss). factors independently associated with mdd were determined using logistic regression analyses. results: of the 455 women recruited between august 1, 2011 and july 31, 2013, 242 (53%) had a diagnosis of mdd. women with mdd were significantly more likely to be separated, had more stressful life events and higher ctq scores. higher perceived social support, conscientiousness and extraversion were independently associated with significantly reduced odds of mdd. there were no significant associations between ctq scores and any of the neo pi-r subscales. limitations: ratings of childhood trauma were based on retrospective recall. conclusion: mdd and a history of childhood trauma were highly prevalent in pakistani women attending general medical clinics. interventions to prevent childhood trauma and promote social support in women may improve public mental health in lmics like pakistan.”
Fuchshuber, J., & Unterrainer, H. F.. (2020). Childhood Trauma, Personality, and Substance Use Disorder: The Development of a Neuropsychoanalytic Addiction Model. Frontiers in Psychiatry
“Background: while traditional psychoanalysis has been criticized as insufficient for the treatment of substance use disorder (sud), recent progress in the field of neuropsychoanalysis has generated new and promising hypotheses regarding its etiology. however, empirical research applying this framework has been sparse. aim and scope: the present overview aims at developing and empirically validating a neuroscientifically informed psychodynamic framework regarding the etiology of sud. for this purpose, this review provides a concise overview of the most relevant historical and contemporary psychoanalytic theories on sud etiology. furthermore, the original research summarized in this paper consists of three studies investigating connections between childhood trauma, primary emotions, personality structure and attachment, as well as their relation to sud development and treatment. conclusions: the results highlight the empirical validity of the neuropsychoanalytic approach towards sud etiology. in particular, the findings underscore the conceptualization of sud as a disorder related to dysfunctional attachment and affect regulation abilities especially linked to increased sadness and anger dispositions, which mediated the relationship between sud and traumatic childhood relationships. based on these findings, a refined model of sud etiology is proposed, which should be tested in future studies.”
Stevanović, A., Frančišković, T., & Vermetten, E.. (2016). Relationship of early-life trauma, war-related trauma, personality traits, and PTSD symptom severity: A retrospective study on female civilian victims of war. European Journal of Psychotraumatology
“Background: consequences of war-related traumatisation have mostly been investigated in military and predominant male populations, while research on female civilian victims of war has been neglected. furthermore, research of post-war posttraumatic stress disorder (ptsd) inwomen has rarely included early-life trauma in their prediction models, so the contribution of trauma in childhood and early youth is still unexplored. objective: to examine the relationship of early-life trauma, war-related trauma, personality traits, and symptoms of posttraumatic stress among female civilian victims of the recent war in croatia. method: the cross-sectional study included 394 participants, 293 war-traumatised adult women civilians, and 101 women without war-related trauma. participants were recruited using the snowball sampling method. the applied instruments included the clinician-administrated ptsd scale (caps), the neo personality inventory-revised (neo-pi-r), thewar stressors assessment questionnaire (wsaq), and the early trauma inventory self report-short form (etisr-sf). a hierarchical multiple regression analysis was performed to assess the prediction model of ptsd symptom severity measured by caps score for current ptsd. results: the prevalence of current ptsd (caps cut-off score[1]65) in this cohort was 20.7%. the regression model that included age, early-life trauma, war-related trauma, neuroticism, and extraversion as statistically significant predictors explained 45.8% of variance in ptsd symptoms. conclusions: older age, exposure to early-life trauma, exposure to war-related traumatic events, high neuroticism, and low extraversion are independent factors associated with higher level of ptsd symptoms among women civilian victims of war.”
Yalch, M. M., Stewart, A. M., & Dehart, R. M.. (2021). Influence of Betrayal Trauma on Antisocial Personality Disorder Traits. Journal of Trauma and Dissociation
“Antisocial personality disorder (aspd) is linked to a number of social problems and accordingly is the focus of intensive empirical study. there is reason to believe that aspd is influenced at least in part by exposure to trauma, but there has been minimal research on the association between trauma and aspd traits. specifically, research has not examined how traumatic experiences with different degrees of interpersonal betrayal differentially influence aspd traits. this is notable in light of recent studies indicating that exposure to traumatic experiences high in betrayal (i.e., high betrayal trauma) is the primary predictor of borderline and narcissistic personality pathology. in this study, we examined the relative associations between high, medium, and low betrayal trauma and aspd traits in a sample recruited from amazon’s mechanical turk (n = 363) using structural equation modeling. results confirmed a strong association between trauma and aspd traits in general, although the influence of specific forms of trauma differed depending on both sex and how trauma was calculated (i.e., in terms of severity vs. exposure). in general, high betrayal trauma was the most consistent predictor of aspd traits for men, whereas medium and low betrayal traumas were more consistently associated with aspd traits for women. study findings extend research on betrayal trauma to more malevolent forms of personality pathology. sex differences in the influence of trauma across aspd traits suggest the possibility of sex-specific personality responses to trauma high in betrayal, a topic that can be addressed in the future research.”
Paris, J.. (1998). Does childhood trauma cause personality disorders in adults?. Canadian Journal of Psychiatry
“Objective: to examine the relationship between trauma in childhood and personality disorders in adulthood. method: a review of the literature was conducted. results: the reported associations between trauma and personality pathology are illuminated by the following research findings: 1) personality is heritable; 2) only a minority of patients with severe personality disorders report childhood trauma; and 3) children are generally resilient, and traumatic experiences do not consistently lead to psychopathology. conclusions: the role of trauma in the personality disorders is best understood in the context of gene-environment interactions.”
Bahari, A., Hasani, J., & Mashhadi Akbar Boojar, M.. (2021). Childhood trauma and type D personality: The endocrine and cardiovascular effects on stress reactivity. Journal of Health Psychology
“Both exaggerated and blunted cardiovascular stress reactions are associated with health problems. moreover, early life experiences and personality traits affect stress responses. regarding the childhood traumas and type d personality, this study aimed to compare the endocrine and cardiovascular reactions against acute laboratory stress. results showed that the simultaneous existence of childhood traumatic experiences and type d personality leads to exaggerated stress reactivity, while each factor results in a blunted cardiovascular response. although the cardiovascular responses are dampened in type d personality people, their endocrine reactions are exaggerated. the underlying mechanisms of blunted cardiovascular reactivity differ between childhood trauma and type d personality groups.”
Rutkowski, K., Dembińska, E., & Walczewska, J.. (2016). Effect of trauma onset on personality traits of politically persecuted victims. BMC Psychiatry
“Background: the hypothesis that traumatic experiences in early childhood impact personality formation and psychopathology is well known in psychology and psychiatry, but this is difficult to verify statistically in methodological terms. the aim of this study, conducted with politically persecuted poles, was to establish the influence of the time when trauma is experienced on the development of psychopathological symptoms. methods: the subjects were divided into two groups: those who had experienced trauma before age five (group 1) and those who experienced trauma at an older age (group 2). subjects in both groups suffered from chronic untreated post-traumatic stress disorder. in order to test the research hypothesis, the minnesota multiphasic personality inventory-2 profiles of both groups were compared using student’s t-test, and the mann-whitney u-test. results: statistically significant between-group differences were found for the f validity scale and the following clinical scales: hypochondriasis, depression, psychopathic deviate, psychasthenia, schizophrenia, and social introversion. all the significantly different scores were higher in the group traumatized in early childhood. people exposed to trauma under age five had profiles similar to those traumatized after age five, but they experienced their symptoms more intensely. conclusions: of clinical significance, higher scores on the psychasthenia, schizophrenia, and social introversion scales, especially on the psychopathic deviate scale, indicated pathology only in the early childhood trauma group. taken together, these symptoms lead to withdrawal and hindrance of social functioning. this outcome confirms the hypothesis of the influence of various early childhood factors (such as trauma) on personality formation and personality traits in adulthood.”
Sansone, R. A., & Sansone, L. A.. (2007). Childhood trauma, borderline personality, and eating disorders: A development cascade. Eating Disorders
“In this article, we discuss the nature and role of trauma in relationship to borderline personality disorder and eating disorders. as is clinically evident, trauma can result in a variety of psychological consequences. these consequences include both axis i and ii disorders. among the axis ii disorders, trauma appears to heighten the risk for the development of borderline, antisocial, avoidant, paranoid, and even schizotypal personality disorders. likewise, trauma may heighten the risk for developing an eating disorder. there appear to be complex inter-relationships among trauma, borderline personality disorder, and eating disorders. in this article, we attempt to summarize these inter-relationships.”
Green, K., & Browne, K.. (2020). Personality Disorder Traits, Trauma, and Risk in Perpetrators of Domestic Violence. International Journal of Offender Therapy and Comparative Criminology
“Crimes committed against partners and family members have devastating effects on victims. unfortunately, recidivism rates for offenders are high, and there is a need to establish risk factors that may be potential treatment targets. this study aimed to investigate childhood maltreatment, symptoms of trauma, and personality disorder (pd) traits in males convicted of domestic violence (dv) offences. data were extracted from the files of 40 males under the supervision of the probation service in the united kingdom. actual return to custody was recorded after a minimum follow-up of 6 months. self-reported childhood maltreatment was associated with increases in pd traits, posttraumatic symptoms, and assessed risk. however, maltreatment did not predict return to custody. tension-reducing behaviours and depressive symptoms predicted return to custody as did antisocial pd. these preliminary findings highlight important areas of future research, in particular, factors which may be relevant treatment targets in reducing the risk of recidivism.”
Li, Y., Lv, Q., Li, B., Luo, D., Sun, X., & Xu, J.. (2020). The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake. BMC Psychiatry
“Background: posttraumatic stress disorder (ptsd) is the most prevalent type of psychiatric disorder among children after an earthquake. this study investigated the role of trauma experiences, personality traits, and genotype in the maintenance of ptsd symptoms. methods: in a previous large-scale epidemiological investigation 1 year after the wenchuan earthquake, 215 children with ptsd symptoms were selected at random with their blood samples collected. all of them were followed up, and their ptsd symptoms were assessed 3 years later. the adolescent version of the ucla ptsd reaction index, the earthquake exposure scale, and the junior eysenck personality questionnaire were used to determine ptsd symptoms, trauma experiences, and personality traits, respectively. we sequenced candidate genes involved in the regulation of long-term potentiation via nmda-type receptors to identify the related snp variations. results: being trapped for a longer period of time, feeling one’s own or a family member’s life to be in danger, losing a close family member or friend, extraversion, neuroticism, trkb, g72 and cntf were found to be associated with the maintenance of ptsd symptoms. conclusions: experiences, personality traits, and genotype influenced the maintenance of ptsd in child survivors who were considered to be followed up without medicine. this result could help to identify potential targets for treatment and promote the rational allocation of medical resources.”
Back, S. N., Flechsenhar, A., Bertsch, K., & Zettl, M.. (2021). Childhood Traumatic Experiences and Dimensional Models of Personality Disorder in DSM-5 and ICD-11: Opportunities and Challenges. Current Psychiatry Reports
“Purpose of review: childhood trauma is an important risk factor for the development of personality disorders (pds), yet most research has been devoted to categorical models of personality pathology. considering the introduction of a dimensional pd model with icd-11, we review current findings related to various forms of childhood trauma, and pds, operationalized in the form of personality functioning and maladaptive traits. we focus on the magnitude of associations and examine specific relationships between emotional and physical trauma with areas of personality functioning and single traits. recent findings: two studies showed a strong association between childhood trauma and personality dysfunction. seven studies, including clinical and forensic samples, demonstrated heterogeneous associations between various forms of childhood trauma and maladaptive traits. overall, four studies indicated a slightly stronger association between personality dysfunction, maladaptive trait expression, and higher levels of emotional trauma than for physical or sexual trauma. regarding specific trait domains and childhood trauma, most studies yielded the strongest associations for either psychoticism or detachment. summary: research on childhood trauma and dimensional pd models (i.e., personality functioning and traits) has the potential to contribute to a better understanding of their complex relationship. however, high intercorrelations among different types of childhood trauma, areas of personality functioning, and trait domains increase the difficulty of disentangling single effects. more research is needed including clinical and non-western samples, especially considering the upcoming icd-11 classification.”
Sheehan, A. E., Bounoua, N., Miglin, R., Spielberg, J. M., & Sadeh, N.. (2021). A multilevel examination of lifetime aggression: Integrating cortical thickness, personality pathology and trauma exposure. Social Cognitive and Affective Neuroscience
“Aggression represents a significant public health concern, causing serious physical and psychological harm. although many studies have sought to characterize the etiology of aggression, research on the contributions of risk factors that span multiple levels of analysis for explaining aggressive behavior is lacking. to address this gap, we investigated the direct and unique contributions of cortical thickness (level 1), pathological personality traits (level 2) and trauma exposure (level 3) for explaining lifetime physical aggression in a high-risk sample of community adults (n = 129, 47.3% men). first, the frequency of lifetime aggression was inversely associated with cortical thickness in regions of prefrontal and temporal cortices that have been implicated in executive functioning, inhibitory mechanisms and socio-emotional processing. further, aggression was positively associated with pathological personality traits (antagonism and disinhibition) and exposure to assaultive trauma. notably, all three levels of analysis (cortical thickness, pathological personality traits and assaultive trauma exposure) explained non-overlapping variance in aggressive behavior when examined simultaneously in integrative models. together, the findings provide a multilevel assessment of the biopsychosocial factors associated with the frequency of aggression. they also indicate that cortical thickness explains novel variance in these harmful behaviors not captured by well-established personality and environmental risk factors for aggression.”
Watkeys, O. J., Kremerskothen, K., Quidé, Y., Fullerton, J. M., & Green, M. J.. (2018). Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review. Neuroscience and Biobehavioral Reviews
“The glucocorticoid receptor gene (nr3c1) is a critical component of the stress response system. cytosine methylation of nr3c1 has been repeatedly associated with trauma and mental disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders, suggesting that nr3c1 methylation may play a role in stress-related psychopathology. we systematically reviewed 55 studies examining nr3c1 dna methylation in association with trauma exposure, psychopathology, gene expression, and/or common genetic variants. overall, a number of nr3c1 cpg sites were significantly associated with trauma or psychopathology, but significant findings were often inconsistent across studies. this lack of consistency is likely influenced by significant methodological variability – experimentally and analytically – across studies. selected common genetic variants show no significant effect on nr3c1 cpg methylation. in contrast, there was ample evidence linking increased methylation of nr3c1 to reduced expression of this gene. the inverse association between methylation and gene expression shown across eight out of ten studies supports the notion that methylation in the promoter region of nr3c1 is associated with transcriptional silencing.”
Light, A. E., Holt-Lunstad, J., Porter, C. L., & Light, K. C.. (2019). Early life trauma: An exploratory study of effects on OXTR and NR3C1 gene expression and nurturing self-efficacy in mothers of infants. International Journal of Psychophysiology
“Background: in animals, adverse early experience alters oxytocinergic and glucocorticoid activity and maternal behavior in adulthood. this preliminary study explored associations among childhood trauma (loss of a parent or sexual abuse in childhood), maternal self-efficacy, and leukocyte gene expression (mrna) of oxytocin and glucocorticoid receptors (oxtr and nr3c1) in mothers of infants. methods: 62 mothers (20 with early life trauma) with healthy 3-month old infants reported maternal self-efficacy, depression, infant temperament, and overall social support; the effects of early trauma on these measures were assessed. of these, 35 mothers (14 with early trauma) underwent blood draws after 2 infant feeding times; their oxtr and nr3c1 mrna was compared to a control group of 25 no-infant women without early trauma, and also was examined for associations with self-efficacy. results: oxtr mrna was increased in mothers of infants versus no-infant controls (p < 0.0003), and mothers with greatest prior maternal experience had higher oxtr than those with less experience (0–2 vs. 3+ older children, p < 0.033). mothers with early trauma and less maternal experience had lower oxtr mrna than no-trauma mothers (p < 0.029) and lower nr3c1 mrna than controls (p < 0.004). mothers with depression also had lower nr3c1 than other mothers (p < 0.003) but did not differ in oxtr. mothers with early trauma also reported their support network to be less helpful and more upsetting and unpredictable than other mothers (p < 0.035–p < 0.005). regarding maternal behavior, in mothers with early trauma, helpful support networks increased self-reported nurturing self-efficacy when babies were not fussy but decreased it with fussy babies (p < 0.05). support was unrelated to self-efficacy in no-trauma mothers. similarly, among mothers with low oxtr or nr3c1 (−1sd, most having early trauma and lower maternal experience), greater support was associated with lower self-efficacy (p < 0.05), while mothers with high oxtr or nr3c1 (+1sd) tended to have higher self-efficacy with greater support. conclusions: these preliminary findings need confirmation in a larger sample but suggest that childhood trauma influences maternal behavior and both oxtr and nr3c1 pathways in mothers of infants, and that both depression and prior maternal experience may be other important factors. effects on maternal behavior appear to require more complex modeling.”
de Assis Pinheiro, J., Freitas, F. V., Borçoi, A. R., Mendes, S. O., Conti, C. L., Arpini, J. K., … Alvares-da-Silva, A. M.. (2021). Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation. Scientific Reports
“The nr3c1 glucocorticoid receptor (gr) gene is a component of the stress response system, which can be regulated by epigenetic mechanisms. nr3c1 methylation has been associated with trauma and mental issues, including depression, post-traumatic stress, anxiety, and personality disorders. previous studies have reported that stressful events are involved in nr3c1 gene methylation, suggesting that its regulation under environmental effects is complex. the present study aimed to analyze associations involving stressors such as socioeconomic status, health conditions, and lifestyle in relation to nr3c1 methylation in adults. this study included 386 individual users of the brazilian public unified health system (sus), and evaluated socioeconomic and health conditions, body mass index, cortisol levels, and lifestyle. data were correlated with nr3c1 methylation, determined using dna pyrosequencing. the results showed that alcohol consumption, overweight, and high cortisol levels were related to nr3c1 demethylation, while depression was related to its methylation. habits, lifestyle, and health status may influence nr3c1 gene regulation via methylation, revealing the complexity of environmental impacts on nr3c1 methylation.”
Çetin, Ş., Sözeri-Varma, G., Çetin, G. O., Türel, S., Uğurlu, T. T., & Özdel, O.. (2022). The Relationship Between Methylation of the Glucocorticoid Receptor Gene (NR3C1) and Childhood Trauma and Alexithymia. Israel Journal of Psychiatry
Show/hide publication abstract
“Background: childhood traumas affect the hypothalamo-pituitary-adrenal (hpa) axis functions, and therefore emotional regulation response to stress. glucocorticoid receptor (gr) gene nr3c1 plays a key role in hpa axis. the aim of the study was to investigate the relationship between methylation of nr3c1 gene with childhood trauma and alexithymia in somatic symptom disorder (ssd) and major depressive disorder (mdd). methods: a total of 48 patients with ssd, 50 patients with mdd and 50 healthy controls were included in the study. mongomery-asberg depression rating scale (madrs), toronto alexithymia scale (tas-20), and the childhood trauma questionnaire (ctq) were applied to the participants. methylation levels of the nr3c1 gene were determined quantitatively in dna blood samples. results: tas-20 and ctq total scores were found to be the highest in patients with ssd. ctq scores were observed to be higher in ssd and mdd compared with the control group. nr3c1 gene methylation levels were found to be lowest in ssd and highest in mdd. there was no correlation between scores of tas-20 and nr3c1 methylation. high alexithymia level was predictive for ssd (or: 1.237, 95% ci: 1.018-1.504). high methylation levels increase the risk of mdd (or: 7.449, 95% ci: 3.702-14.986), decrease the risk of ssd (or: 0.00006 95% ci: 0.000-0.038). conclusion: our results show that emotion processing processes and gr methylation are different in both disorders. childhood trauma may be related to epigenetic changes in the gr gene. the type of epigenetic changes may result in vulnerability to different psychiatric disorders.”
Alexander, N., Kirschbaum, C., Wankerl, M., Stauch, B. J., Stalder, T., Steudte-Schmiedgen, S., … Miller, R.. (2018). Glucocorticoid receptor gene methylation moderates the association of childhood trauma and cortisol stress reactivity. Psychoneuroendocrinology
“Exposure to childhood trauma (ct) has been linked to sustained dysregulations of major stress response systems, including findings of both exaggerated and attenuated hypothalamus–pituitary–adrenal (hpa) axis activity. likewise, ct constitutes a common risk factor for a broad range of psychiatric conditions that involve distinct neuroendocrine profiles. in this study, we investigated the role of epigenetic variability in a stress-related gene as a potential mediator or moderator of such differential trajectories in ct survivors. for this, we screened adult volunteers for ct and recruited a healthy sample of 98 exposed (67 with mild-moderate, 31 with moderate-severe exposure) and 102 control individuals, with an equal number of males and females in each group. dna methylation (dnam) levels of the glucocorticoid receptor exon 1f promoter (nr3c1-1f) at functionally relevant sites were analyzed via bisulfite pyrosequencing from whole blood samples. participants were exposed to a laboratory stressor (trier social stress test) to assess salivary cortisol stress responses. the major finding of this study indicates that dnam in a biologically relevant region of nr3c1-1f moderates the specific direction of hpa-axis dysregulation (hypo- vs. hyperreactivity) in adults exposed to moderate-severe ct. those trauma survivors with increased nr3c1-1f dnam displayed, on average, 10.4 nmol/l (62.3%) higher peak cortisol levels in response to the tsst compared to those with low dnam. in contrast, unexposed and mildly-moderately exposed individuals displayed moderately sized cortisol stress responses irrespective of nr3c1-1f dnam. contrary to some prior work, however, our data provides no evidence for a direct association of ct and nr3c1-1f dnam status. according to this study, epigenetic changes of nr3c1-1f may provide a more in-depth understanding of the highly variable neuroendocrine and pathological sequelae of ct.”
Vangeel, E. B., Kempke, S., Bakusic, J., Godderis, L., Luyten, P., Van Heddegem, L., … Claes, S.. (2018). Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients. Journal of Psychosomatic Research
“Objective although the precise mechanisms are not yet understood, previous studies have suggested that chronic fatigue syndrome (cfs) is associated with hypothalamic-pituitary-adrenal (hpa) axis dysregulation and trauma in early childhood. consistent with findings suggesting that early life stress-induced dna methylation changes may underlie dysregulation of the hpa axis, we previously found evidence for the involvement of glucocorticoid receptor (gr) gene (nr3c1) methylation in whole blood of cfs patients. methods in the current study, we assessed nr3c1-1f region dna methylation status in peripheral blood from a new and independent sample of 80 female cfs patients and 91 female controls. in cfs patients, history of childhood trauma subtypes was evaluated using the childhood trauma questionnaire short form (ctq-sf). results although absolute methylation differences were small, the present study confirms our previous findings of nr3c1-1f dna hypomethylation at several cpg sites in cfs patients as compared to controls. following multiple testing correction, only cpg_8 remained significant (dna methylation difference: 1.3% versus 1.5%, p < 0.001). in addition, we found associations between dna methylation and severity of fatigue as well as with childhood emotional abuse in cfs patients, although these findings were not significant after correction for multiple testing. conclusions in conclusion, we replicated findings of nr3c1-1f dna hypomethylation in cfs patients versus controls. our results support the hypothesis of hpa axis dysregulation and enhanced gr sensitivity in cfs.”
Martín-Blanco, A., Ferrer, M., Soler, J., Salazar, J., Vega, D., Andión, O., … Pascual, J. C.. (2014). Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. Journal of Psychiatric Research
Perroud, N., Dayer, A., Piguet, C., Nallet, A., Favre, S., Malafosse, A., & Aubry, J. M.. (2014). Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder. British Journal of Psychiatry
“Background early-life adversities represent risk factors for the development of bipolar affective disorder and are associated with higher severity of the disorder. this may be the consequence of a sustained alteration of the hypothalamic-pituitary-adrenal (hpa) axis resulting from epigenetic modifications of the gene coding for the glucocorticoid receptor (nr3c1). aims to investigate whether severity of childhood maltreatment isassociated with increased methylation of the exon 1f nr3c1 promoter in bipolar disorder. method a sample of people with bipolar disorder (n = 99) were assessed for childhood traumatic experiences. the percentage of nr3c1 methylation was measured for each participant.results the higher the number of trauma events, the higher was the percentage of nr3c1 methylation (β = 0.52, 95% ci 0.46-0.59, p”0.0001). the severity of each type of maltreatment (sexual, physical and emotional) was also associated with nr3c1 methylation status. conclusionsearly-life adversities have a sustained effect on the hpa axis through epigenetic processes and this effect may be measured in peripheral blood. this enduring biological impact of early trauma may alter the development of the brain and lead to adult psychopathological disorder. declaration of interest none.”
Straight, B., Fisher, G., Needham, B. L., Naugle, A., Olungah, C., Wanitjirattikal, P., … Lalancette, C.. (2021). Lifetime stress and war exposure timing may predict methylation changes at NR3C1 based on a pilot study in a warrior cohort in a small-scale society in Kenya. American Journal of Human Biology
“Objectives: candidate gene methylation studies of nr3c1 have identified associations with psychosocial adversity, including war trauma. this pilot study (sample sizes from 22 to 45 for primary analyses) examined nr3c1 methylation in a group of kenyan pastoralist young men in relation to culturally relevant traumatic experiences, including participation in coalitional lethal gun violence. methods: adolescent and young adult samburu men (‘warriors’) were recruited for participation. dna was obtained from whole saliva and methylation analyses performed using mass spectrometry. we performed a data reduction of variables from a standardized instrument of lifetime stress using a factor analysis and we assessed the association between the extracted factors with culturally relevant and cross-culturally comparative experiences. results: cumulative lifetime trauma exposure and forms of violence to which warriors are particularly susceptible were associated with dna methylation changes in the nr3c1 1f promoter region but not in the nr3c1 1d promoter region. however, sensitivity analyses revealed significant associations between individual cpg sites in both regions and cumulative stress exposures, war exposure timing, and war fatalities. conclusions: this study supports the importance of nr3c1 methylation changes in response to challenging life circumstances, including in a global south cultural context that contrasts in notable ways from global north contexts and from the starkly tragic examples of the rwandan genocide and war-associated rape explored in recent studies. timing of traumatic exposure and culturally salient means to measure enduring symptoms of trauma remain important considerations for dna methylation studies.”
Malhi, G. S., Das, P., Outhred, T., Dobson-Stone, C., Irwin, L., Gessler, D., … Mannie, Z.. (2019). Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls. Australian and New Zealand Journal of Psychiatry
“Objective: adolescence is a time of increased susceptibility to environmental stress and mood disorders, and girls are particularly at risk. genes interacting with the environment (g × e) are implicated in hypothalamic-pituitary-adrenal axis dysregulation, hippocampal volume changes and risk or resilience to mood disorders. in this study, we assessed the effects of stress system g × e interactions on hippocampal volumes and cortisol secretion in adolescent girls. methods: we recruited 229 girls aged 12–18 years, and scans were obtained from 202 girls. of these, 76 had been exposed to higher emotional trauma (abuse or neglect). hippocampal volumes were measured using freesurfer and high-resolution structural magnetic resonance imaging scans. saliva samples were collected for measurement of cortisol levels and genotyping of stress system genes: fkbp5, nr3c1 (both n = 194) and nr3c2 (n = 193). results: among girls with the ‘g’ allelic variant of the nr3c1 gene, those who had been exposed to higher emotional trauma had significantly smaller left hippocampal volumes (n = 44; mean = 4069.58 mm 3 , standard deviation = 376.99) than girls who had been exposed to minimal emotional trauma with the same allelic variant (n = 69; mean = 4222.34 mm 3 , standard deviation = 366.74). conclusion: in healthy adolescents, interactions between emotional trauma and the ‘protective’ nr3c1 ‘gg’ variant seem to induce reductions in left hippocampal volumes. these g × e interactions suggest that vulnerability to mood disorders is perhaps driven by reduced ‘protection’ that may be specific to emotional trauma. this novel but preliminary evidence has implications for targeted prevention of mood disorders and prospective multimodal neuroimaging and longitudinal studies are now needed to investigate this possibility.”
Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H.. (2015). Early life trauma, depression and the glucocorticoid receptor gene-an epigenetic perspective. Psychological Medicine
“Hopes to identify genetic susceptibility loci accounting for the heritability seen in unipolar depression have not been fully realized. family history remains the ‘gold standard’ for both risk stratification and prognosis in complex phenotypes such as depression. meanwhile, the physiological mechanisms underlying life-event triggers for depression remain opaque. epigenetics, comprising heritable changes in gene expression other than alterations of the nucleotide sequence, may offer a way to deepen our understanding of the aetiology and pathophysiology of unipolar depression and optimize treatments. a heuristic target for exploring the relevance of epigenetic changes in unipolar depression is the hypothalamic-pituitary-adrenal (hpa) axis. the glucocorticoid receptor (gr) gene (nr3c1) has been found to be susceptible to epigenetic modification, specifically dna methylation, in the context of environmental stress such as early life trauma, which is an established risk for depression later in life. method. in this paper we discuss the progress that has been made by studies that have investigated the relationship between depression, early trauma, the hpa axis and the nr3c1 gene. difficulties with the design of these studies are also explored. results. future efforts will need to comprehensively address epigenetic natural histories at the population, tissue, cell and gene levels. the complex interactions between the epigenome, genome and environment, as well as ongoing nosological difficulties, also pose significant challenges. conclusions. the work that has been done so far is nevertheless encouraging and suggests potential mechanistic and biomarker roles for differential dna methylation patterns in nr3c1 as well as novel therapeutic targets.”
Qi, R., Luo, Y., Zhang, L., Weng, Y., Surento, W., Xu, Q., … Thompson, P. M.. (2021). Decreased functional connectivity of hippocampal subregions and methylation of the NR3C1 gene in Han Chinese adults who lost their only child. Psychological Medicine
“Background losing one’s only child is a major traumatic life event that may lead to post-traumatic stress disorder (ptsd); however, the underlying mechanisms of its psychological consequences remain poorly understood. here, we investigated subregional hippocampal functional connectivity (fc) networks based on resting-state functional magnetic resonance imaging and the deoxyribonucleic acid methylation of the human glucocorticoid receptor gene (nr3c1) in adults who had lost their only child. methods a total of 144 han chinese adults who had lost their only child (51 adults with ptsd and 93 non-ptsd adults [trauma-exposed controls]) and 50 controls without trauma exposure were included in this fmri study (age: 40-67 years). fcs between hippocampal subdivisions (four regions in each hemisphere: cornu ammonis1 [ca1], ca2, ca3, and dentate gyrus [dg]) and methylation levels of the nr3c1 gene were compared among the three groups. results trauma-exposed adults, regardless of ptsd diagnosis, had weaker positive fc between the left hippocampal ca1, left dg, and the posterior cingulate cortex, and weaker negative fc between the right ca1, right dg, and several frontal gyri, relative to healthy controls. compared to non-ptsd adults, ptsd adults showed decreased negative fc between the right ca1 region and the right middle/inferior frontal gyri (mfg/ifg), and decreased negative fc between the right dg and the right superior frontal gyrus and left mfg. both trauma-exposed groups showed lower methylation levels of the nr3c1 gene. conclusions adults who had lost their only child may experience disrupted hippocampal network connectivity and nr3c1 methylation status, regardless of whether they have developed ptsd.”
Schür, R. R., van Leeuwen, J. M. C., Houtepen, L. C., Joëls, M., Kahn, R. S., Boks, M. P., & Vinkers, C. H.. (2018). Glucocorticoid receptor exon 1 F methylation and the cortisol stress response in health and disease. Psychoneuroendocrinology
“Childhood trauma has been proposed to increase vulnerability to develop psychopathology in part through an altered cortisol stress response. research in rats has suggested that this effect is mediated by methylation in the glucocorticoid receptor 1 7 region (gr-1 7 or gr-1 f in humans), with higher methylation after poor maternal care leading to an increased cortisol stress response in adulthood. in humans, the associations between childhood trauma and gr-1 f methylation or the cortisol stress response are equivocal. remarkably, evidence for the relation between gr-1 f methylation and the cortisol stress response has been conflicting as well. to further explore this, we investigated the associations of peripheral gr-1 f methylation (52 cpgs) with the cortisol stress response (trier social stress test) and with childhood trauma in three independent studies (total n = 241) including healthy controls, patients with schizophrenia and bipolar disorder and unaffected siblings of patients with one of these disorders. we did not find any significant association between gr-1 f methylation and the cortisol stress response (areas under the curve) or childhood trauma, nor did we observe any group differences between patients, siblings and healthy controls. our findings do not support gr-1 f methylation as a proxy for the cortisol stress response, nor its link with childhood trauma or psychopathology. these results suggest that multifactorial models for stress-related psychopathology are needed. alternatively, future longitudinal studies may reveal gr-1 f methylation to be a useful parameter at an individual level.”
Yehuda, R., Flory, J. D., Bierer, L. M., Henn-Haase, C., Lehrner, A., Desarnaud, F., … Meaney, M. J.. (2015). Lower Methylation of Glucocorticoid Receptor Gene Promoter 1F in Peripheral Blood of Veterans with Posttraumatic Stress Disorder. Biological Psychiatry
“BACKGROUND: enhanced glucocorticoid receptor (gr) sensitivity is present in people with posttraumatic stress disorder (ptsd), but the molecular mechanisms of gr sensitivity are not understood. epigenetic factors have emerged as one potential mechanism that account for how trauma exposure leads to sustained ptsd symptoms given that ptsd develops in only a subset of trauma survivors. methods: cytosine methylation of a relevant promoter of the gr gene (nr3c1-1f promoter) and three functional neuroendocrine markers of hypothalamic-pituitary-adrenal axis function were examined in a sample of 122 combat veterans. results: lower nr3c1-1f promoter methylation in peripheral blood mononuclear cells (pbmcs) was observed in combat veterans with ptsd compared with combat-exposed veterans who did not develop ptsd. nr3c1-1f promoter methylation was also associated with three functional measures of glucocorticoid activity that have been associated with ptsd in combat veterans: pbmcs’ lysozyme inhibition on the lysozyme suppression test, plasma cortisol decline on the low-dose (.50 mg) dexamethasone suppression test, and 24-hour urinary cortisol excretion. finally, nr3c1-1f promoter methylation was inversely correlated with clinical markers and symptoms associated with ptsd. conclusions: alterations in nr3c1-1f promoter methylation may reflect enduring changes resulting from combat exposure that lead to functional neuroendocrine alterations. because epigenetic measures are thought to reflect enduring effects of environmental exposures, they may be useful in distinguishing combat-exposed veterans who do or do not develop ptsd.”
Vangeel, E., Van Den Eede, F., Hompes, T., Izzi, B., Del Favero, J., Moorkens, G., … Claes, S.. (2015). Chronic fatigue syndrome and DNA hypomethylation of the glucocorticoid receptor gene promoter 1F Region: Associations with HPA Axis Hypofunction and childhood trauma. Psychosomatic Medicine
“Objectives: chronic fatigue syndrome (cfs) has been associated with hypothalamic-pituitary-adrenal axis hypofunction and enhanced glucocorticoid receptor (gr) sensitivity. in addition, childhood trauma is considered a major risk factor for the syndrome. this study examinesdna methylation of the gr gene (nr3c1) in cfs and associations with childhood sexual and physical trauma. methods: quantification of dna methylation within the 1f promoter region of nr3c1 was performed in 76 female patients (46 with no/mild and 30 with moderate/severe childhood trauma) and 19 healthy controls by using sequenom epityper. further, we examined the association of nr3c1-1f promoter methylation with the outcomes of the low-dose (0.5 mg) dexamethasone/corticotropin-releasing factor test in a subset of the study population. mann-whitney u tests and spearman correlations were used for statistical analyses. results: overall nr3c1-1f dna methylation was lower in patients with cfs than in controls. after cytosine guanine dinucleotide (cpg)-specific analysis, cpg-1.5 remained significant after bonferroni correction (adjusted p = .0014).within the cfs group, overall methylation (p = 0.477, p = .016) and selective cpg units (cpg-1.5: p = 0.538, p = .007; cpg-12.13: p = 0.448, p = .025) were positively correlated with salivary cortisol after dexamethasone administration. there was no significant difference in nr3c1-1f methylation between traumatized and nontraumatized patients. conclusions:we found evidence of nr3c1 promoter hypomethylation in female patients with cfs and the functional relevance of these differences was consistent with the hypothalamic-pituitary-adrenalaxis hypofunction hypothesis (gr hypersuppression). however, we found no evidence of an additional effect of childhood trauma on cfs via alterations in nr3c1 methylation.”
Fiacco, S., Gardini, E. S., Mernone, L., Schick, L., & Ehlert, U.. (2019). DNA Methylation in Healthy Older Adults With a History of Childhood Adversity—Findings From the Women 40+ Healthy Aging Study. Frontiers in Psychiatry
“Background: adversity in early development seems to increase the risk of stress-related somatic disorders later in life. physiologically, functioning of the hypothalamic–pituitary–adrenal and hypothalamic–pituitary–gonadal axes is often discussed as long-term mediators of risk. in particular, dna methylation in the glucocorticoid receptor gene promoter (nr3c1) has been associated with type and strength of early life adversity and subsequent effects on hpa axis signaling in humans. animal studies, moreover, suggest changes in dna methylation in the estrogen receptor gene (erα) upon early life adversity. we investigated the association of type and severity of childhood adversity with methylation in nr3c1 and erα and additionally considered associations between methylation and steroid hormone secretion. methods: the percentage of methylation within the nr3c1 promoter and the erα shore was investigated using dried blood spot samples of 103 healthy women aged 40–73 years. childhood adversity was examined with the childhood trauma questionnaire. linear regression analyses were performed with methylation as dependent variable and the experience of emotional abuse and neglect, physical abuse and neglect, and sexual abuse (compared to non-experience) as independent variables. all analyses were controlled for age, bmi, annual household income, and smoking status and were adjusted for multiple testing. results: overall, over 70% of the sample reported having experienced any kind of abuse or neglect of at least low intensity. there were no significant associations between childhood adversity and methylation in the nr3c1 promoter (all p >.10). participants reporting emotional abuse showed significantly higher methylation in the erα shore than those who did not (p =.001). additionally, higher levels of adversity were associated with higher levels of erα shore methylation (p =.001). conclusion: in healthy women, early life adversity does not seem to result in nr3c1 promoter hypermethylation in midlife and older age. this is the first study in humans to suggest that childhood adversity might, however, epigenetically modify the erα shore. further studies are needed to gain a better understanding of why some individuals remain healthy and others develop psychopathologies in the face of childhood adversity.”
Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., … Malafosse, A.. (2011). Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: A link with the severity and type of trauma. Translational Psychiatry
Womersley, J. S., Martin, L. I., van der Merwe, L., Seedat, S., & Hemmings, S. M. J.. (2018). Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents. Metabolic Brain Disease
“Anxiety sensitivity (as) is characterised by the fear of anxiety-related symptoms and is a risk factor for the development of anxiety-related disorders. we examined whether genetic variation in three stress response genes, crhr1, nr3c1, and fkbp5, interact with childhood trauma (ct) to predict as in south african adolescents. xhosa (n = 634) and coloured (n = 317) students completed self-report measures of as and ct, and a total of eighteen polymorphisms within crhr1, nr3c1, and fkbp5 were genotyped. differences in as based on genetic variation and ct were analysed within population and gender groups using multiple linear regression. associations were found between as and fkbp5 rs9296158 (p = 0.025) and rs737054 (p = 0.045) in coloured males. analysis of gene x ct interactions indicated that nr3c1 rs190488 cc-genotype, nr3c1 rs10482605 g-allele addition, and fkbp5 rs3800373 c-allele addition protect against as with increasing ct in xhosa females (p = 0.009), xhosa males (p = 0.036) and coloured males (p = 0.049), respectively. we identified two different protective single nucleotide polymorphism (snp) combinations in a four-snp crhr1 haplotype in coloured males. an analysis of the interaction between ct and a six-snp fkbp5 haplotype in coloured males revealed both protective and risk allelic combinations. our results provide evidence for the influence of both genetic variation in crhr1, nr3c1 and fkbp5, as well as ct x snp interactions, on as in south african adolescents. this study reinforces the importance of examining the influence of gene-environment (g x e) interactions within gender and population groups.”
Rovaris, D. L., Mota, N. R., Bertuzzi, G. P., Aroche, A. P., Callegari-Jacques, S. M., Guimarães, L. S. P., … Grassi-Oliveira, R.. (2015). Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment. Journal of Psychiatric Research
“The aim of this study was to analyze hypotheses-driven gene-environment and gene-gene interactions in smoked (crack) cocaine addiction by evaluating childhood neglect and polymorphisms in mineralocorticoid and glucocorticoid receptor genes (nr3c2 and nr3c1, respectively). one hundred thirty-nine crack/cocaine-addicted women who completed 3 weeks of follow-up during early abstinence composed our sample. childhood adversities were assessed using the childhood trauma questionnaire (ctq), and withdrawal symptoms were assessed using the cocaine selective severity assessment (cssa) scale. conditional logistic regression with counterfactuals and generalized estimating equation modeling were used to test gene-environment and gene-gene interactions. we found an interaction between the rs5522-val allele and childhood physical neglect, which altered the risk of crack/cocaine addiction (odds ratio=4.0, p=0.001). moreover, a nr3c2-nr3c1 interaction (p = 0.002) was found modulating the severity of crack/cocaine withdrawal symptoms. in the post hoc analysis, concomitant carriers of the nr3c2 rs5522-val and nr3c1 rs6198-g alleles showed lower overall severity scores when compared to other genotype groups (p-values ≤ 0.035). this gene-environment interaction is consistent with epidemiological and human experimental findings demonstrating a strong relationship between early life stress and the hypothalamic-pituitary-adrenal (hpa) axis dysregulation in cocaine addiction. additionally, this study extended in crack/cocaine addiction the findings previously reported for tobacco smoking involving an interaction between nr3c2 and nr3c1 genes.”
Holmes, L., Shutman, E., Chinaka, C., Deepika, K., Pelaez, L., & Dabney, K. W.. (2019). Aberrant epigenomic modulation of glucocorticoid receptor gene (NR3C1) in early life stress and major depressive disorder correlation: Systematic review and quantitative evidence synthesis. International Journal of Environmental Research and Public Health
“Early life stress (els) induced by psychological trauma, child maltreatment, maternal separation, and domestic violence predisposes to psycho-behavioral pathologies during adulthood, namely major depressive disorder (mdd), anxiety, and bipolar affective disorder. while environmental data are available in illustrating this association, data remain to be established on the epigenomic underpinning of the nexus between els and mdd predisposition. specifically, despite the observed aberrant epigenomic modulation of the nr3c1, a glucocorticoid receptor gene, in early social adversity and social threats in animal and human models, reliable scientific data for intervention mapping in reducing social adversity and improving human health is required. we sought to synthesize the findings of studies evaluating (a) epigenomic modulations, mainly dna methylation resulting in mdd following els, (b) epigenomic modifications associated with els, and (c) epigenomic alterations associated with mdd. a systematic review and quantitative evidence synthesis (qes) were utilized with the random effect meta-analytic procedure. the search strategy involved both the pubmed and hand search of relevant references. of the 1534 studies identified through electronic search, 592 studies were screened, 11 met the eligibility criteria for inclusion in the qes, and 5 examined els and mdd; 4 studies assessed epigenomic modulation and els, while 2 studies examined epigenomic modulations and mdd. the dense dna methylation of the 1f exon of the nr3c1, implying the hypermethylated region of the glucocorticoid receptor gene, was observed in the nexus between els and mdd, common effect size (ces) = 14.96, 95%ci, 10.06–19.85. with respect to epigenomic modulation associated with child els, hypermethylation was observed, ces = 23.2%, 95%ci, 8.00–38.48. in addition, marginal epigenomic alteration was indicated in mdd, where hypermethylation was associated with increased risk of mdd, ces = 2.12%, 95%ci, −0.63–4.86. substantial evidence supports the implication of nr3c1 and environmental interaction, mainly dna methylation, in the predisposition to mdd following els. this qes further supports aberrant epigenomic modulation identified in els as well as major depressive episodes involving dysfunctional glucocorticoid-mediated negative feedback as a result of allostatic overload. these findings recommend prospective investigation of social adversity and its predisposition to the mdd epidemic via aberrant…”
Grillault Laroche, D., Curis, E., Bellivier, F., Nepost, C., Courtin, C., Etain, B., & Marie-Claire, C.. (2020). Childhood maltreatment and HPA axis gene expression in bipolar disorders: A gene network analysis. Psychoneuroendocrinology
“Introduction: bipolar disorder (bd) is highly associated with childhood maltreatment (cm), the exposure to such early adversity being suggested to disrupt the expression of several biological pathways. this study aims at exploring associations between the mrna levels of 9 hpa axis genes in lymphoblastoid cell lines from patients with bd according to their self-reported exposure to cm. methods: the sample consisted of 33 caucasian patients with a diagnosis of bd type 1, assessed for the exposure to cm with the childhood trauma questionnaire (ctq). quantitative rt-pcr was performed on 9 transcripts of the hpa axis genes: dgkh, fkbp5, nr3c1, sgk1, sgk2, sgk3, ska2, stat5a and ucn. rt-qpcr data were analyzed using the method of disjoint gene networks with sarp.compo package for r. results: we found no associations between ctq total score and the amount of hpa axis transcripts neither in univariate analyses, nor with network analyses. emotional abuse (ea) was associated with a significant decreased expression of two transcripts, dgkh (p = 0.009) and nr3c1 (p = 0.04). this was confirmed by the disjoint network analysis, which showed that nr3c1 and dgkh were expressed differently from the rest of the hpa axis network in presence of emotional abuse. discussion: this study described the expression levels of a comprehensive set of hpa axis genes according to childhood maltreatment in a sample of patients with bd type 1 and suggested that emotional abuse decreased the expression of nr3c1 and dgkh. our results require further replication in independent larger samples.”
Sheerin, C. M., Lind, M. J., Bountress, K. E., Marraccini, M. E., Amstadter, A. B., Bacanu, S. A., & Nugent, N. R.. (2020). Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder. Journal of Traumatic Stress
“The hypothalamic-pituitary-adrenal (hpa) axis has been of interest in attempts to identify genetic vulnerability for posttraumatic stress disorder (ptsd). although numerous hpa-axis genes have been implicated in candidate gene studies, the findings are mixed and interpretation is limited by study design and methodological inconsistencies. to address these inconsistencies in the ptsd candidate gene literature, we conducted meta-analyses of hpa-related genes from both a traditional single nucleotide polymorphism (snp)–level analysis and a gene-level analysis, using novel methods aggregating markers in the same gene. database searches (pubmed and psycinfo) identified 24 unique articles examining six hpa-axis genes in ptsd; analyses were conducted on four genes (adcyap1r1, crhr1, fkbp5, nr3c1) that met study eligibility criteria (original research, human subjects, main effect association study of selected genes, ptsd as an outcome, trauma-exposed control group) and had sufficient data and number of studies for use in meta-analysis, within 20 unique articles. findings from snp-level analyses indicated that two variants (rs9296158 in fkbp5 and rs258747 in nr3c1) were nominally associated with ptsd, ps =.001 and.001, respectively, following multiple testing correction. at the gene level, significant relations between ptsd and both nr3c1 and fkbp5 were detected and robust to sensitivity analyses. although study limitations exist (e.g., varied outcomes, inability to test moderators), taken together, these results provide support for fkbp5 and nr3c1 in risk for ptsd. overall, this work highlights the utility of meta-analyses in resolving discrepancies in the literature and the value of adopting gene-level approaches to investigate the etiology of ptsd.”
Peng, H., Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., … Zhao, J.. (2018). Childhood Trauma, DNA Methylation of Stress-Related Genes, and Depression: Findings from Two Monozygotic Twin Studies. Psychosomatic Medicine
“Objective dna methylation has been associated with both early life stress and depression. this study examined the combined association of dna methylation at multiple cpg probes in five stress-related genes with depressive symptoms and tested whether these genes methylation mediated the association between childhood trauma and depression in two monozygotic (mz) twin studies. methods the current analysis comprised 119 mz twin pairs (84 male pairs [mean = 55 years] and 35 female pairs [mean = 36 years]). peripheral blood dna methylation of five stress-related genes (bdnf, nr3c1, slc6a4, maoa, and maob) was quantified by bisulfite pyrosequencing or 450k beadchip. we applied generalized poisson linear-mixed models to examine the association between each single cpg methylation and depressive symptoms. the joint associations of multiple cpgs in a single gene or all five stress-related genes as a pathway were tested by weighted truncated product method. mediation analysis was conducted to test the potential mediating effect of stress gene methylation on the relationship between childhood trauma and depressive symptoms. results multiple cpg probes showed nominal individual associations, but very few survived multiple testing. gene-based or gene-set approach, however, revealed significant joint associations of dna methylation in all five stress-related genes with depressive symptoms in both studies. moreover, two cpg probes in the bdnf and nr3c1 mediated approximately 20% of the association between childhood trauma and depressive symptoms. conclusions dna methylation at multiple cpg sites are jointly associated with depressive symptoms and partly mediates the association between childhood trauma and depression. our results highlight the importance of testing the combined effects of multiple cpg loci on complex traits and may unravel a molecular mechanism through which adverse early life experiences are biologically embedded.”
Nöthling, J., Malan-Müller, S., Abrahams, N., Hemmings, S. M. J., & Seedat, S.. (2020). Epigenetic alterations associated with childhood trauma and adult mental health outcomes: A systematic review. World Journal of Biological Psychiatry
“Objectives: multiple, chronic and repeated trauma exposure in childhood is associated with adverse mental health outcomes in adulthood. in this paper we synthesise the literature on epigenetic modifications in childhood trauma (ct) and the mediating effects of differential epigenetic mechanisms on the association between ct and the later onset of psychiatric disorders. methods: we reviewed the literature up to march 2018 in four databases: pubmed, web of science, ebscohost and scopus. non-human studies were excluded. all studies investigating ct exposure both in healthy adults (18years and older) and adults with psychiatric disorders were included. results: thirty-six publications were included. for mood disorders, methylation of the glucocorticoid receptor nr3c1 gene, specifically at the ngfi-a binding site in exon 1f, and correlation with ct was a robust finding. several studies documented differential methylation of slc6a4, bdnf, oxtr and fkbp5 in association with ct. common pathways identified include neuronal functioning and maintenance, immune and inflammatory processes, chromatin and histone modification, and transcription factor binding. conclusions: a variety of epigenetic mediators that lie on a common pathway between ct and psychiatric disorders have been identified, although longitudinal studies and consistency in methodological approach are needed to disentangle cause and effect associations.”
Brown, V.. (2021). Methylation of the glucocorticoid receptor gene NR3C1: a summary for clinicians working with children and families. BJPsych Open
“Aims it has been shown that the glucocorticoid receptor nr3c1 gene can be methylated (‘switched off’) in response to early adversity. methylation has also been linked to physiological changes in the body’s response to stress by changing the sensitivity of the hypothalamic-pituitary-adrenal (hpa) axis. in adults, associations have been made between nr3c1 methylation and borderline personality disorder, depression and post-traumatic stress disorder. environmental and social co-variates increase with lifespan so establishing cause and effect is difficult. studies in children, then, may illuminate patterns to inform current hypotheses. this paper reviews the literature on children and adolescents linking glucocorticoid gene receptor nr3c1 to the psychopathology of mental illness. findings are presented in an accessible manner to engage people less familiar with genetics and to inform frontline clinicians of this quickly growing area of research. method medline and psychinfo were searched for relevant peer-reviewed original research using the following keywords and associated mesh terms: nrc31, glucocorticoid receptor gene, methylation, epigenetics, child, adolescent, trauma, psychopathology, gene expression. result 14 studies were identified involving 5475 young people. degree of nr3c1 methylation was associated with severity of early life adversity. methylation was linked with psychopathology including borderline personality disorder, internalising symptoms and externalising symptoms with sex differences. the most consistent association was with depression. methylation seems to modulate the interaction between environment and genetics with the suggestion that the effect may be protective in some cases. however, longitudinal genetic sampling was only conducted in one study. conclusion heterogeneity of studies in the epigenetics field are discussed but should not detract from future possibilities. the hope is to identify therapeutic targets or monitor response to treatment as we work to better understand the biology of developmental psychology, mental illness and resilience. there is a growing understanding that epigenetic modifications likely change over time and clinical significance is most likely dictated by changes at multiple gene locations. thus future research may need to move away from single gene research typically employed in favour of longitudinal whole genome studies in larger population studies. it is time that clinician…”
Fritz Gottlieb Karl Lenz (9 March 1887 in Pflugrade, Pomerania – 6 July 1976 in Göttingen, Lower Saxony) was a German geneticist, member of the Nazi Party, and influential specialist in eugenics in Nazi Germany.
Outline of Human Genetics and Racial Hygiene (Grundriss der menschlichen Erblichkeitslehre und Rassenhygiene)
Human reproduction and eugenics as a public issue: The contemporary reception of a German standard textbook on racial hygiene 1921–1941
Summary: Based on contemporary book reviews, the author analyses the reception of and impact exerted by the German standard textbook of eugenics in the inter-worldwar period, the two-volume «Human Heredity» («Menschliche Erblichkeitslehre und Rassenhygiene», München: Lehmanns, 1921–1940) written by Erwin Baur, Eugen Fischer and Fritz Lenz. Probably, this book consolidated racial hygiene as a scientific discipline and provided an important background legitimating both racial politics and legislation during the National Socialist regime in Germany.
This chapter examines the way human heredity was taught in the college-preparatory schools in Germany prior to and during the Third Reich, revealing that eugenics was taught even before the Nazi seizure of power. It shows that human genetics instruction at the secondary school level was a professional and ethical gray zone where the responsibility of biology teachers for inculcating their students with racial hygiene ideas comes into question.
Bibliography
AR 190-8. Enemy Prisoners of War, Retained Personnel, Civilian Internees and
Other Detainees. 1 October 1997.
CJCS Instruction 3110.05C. Joint Psychological Operations Supplement to the
Joint Strategic Capabilities Plan FY 2002 (CJCSI 3110.01 Series).
18 July 2003.
DOD Directive 5111.10. Assistant Secretary of Defense for Special Operations and
Low-Intensity Conflict (ASD[SO/LIC]). 22 March 1995.
DOD Instruction S-3321-1. (S) Overt Psychological Operations Conducted by the
Military Services in Peacetime and in Contingencies Short of Declared War
(U). 26 July 1984.
FM 3-0. Operations. 14 June 2001.
FM 3-05.102. Army Special Operations Forces Intelligence. 31 August 2001.
FM 3-05.301. Psychological Operations Tactics, Techniques, and Procedures.
31 December 2003.
FM 3-13. Information Operations: Doctrine, Tactics, Techniques, and Procedures.
28 November 2003.
FM 3-19.40. Military Police Internment/Resettlement Operations. 1 August 2001.
FM 5-0 (FM 101-5). Army Planning and Orders Production. 20 January 2005.
FM 27-10. The Law of Land Warfare. 18 July 1956, with Change 1, 15 July 1976.
FM 34-1. Intelligence and Electronic Warfare Operations. 27 September 1994.
FM 34-2. Collection Management and Synchronization Planning. 8 March 1994.
FM 100-7. Decisive Force: The Army in Theater Operations. 31 May 1995.
FM 100-25. Doctrine for Army Special Operations Forces. 1 August 1999.
JP 0-2. Unified Action Armed Forces (UNAAF). 10 July 2001.
JP 1-02. Department of Defense Dictionary of Military and Associated Terms.
12 April 2001 (Amended through 30 November 2004).
JP 3-0. Doctrine for Joint Operations. 10 September 2001.
JP 3-05. Doctrine for Joint Special Operations. 17 April 1998.
JP 3-08. Interagency Coordination During Joint Operations, Volumes I and II.
9 October 1996.
JP 3-53. Doctrine for Joint Psychological Operations. 5 September 2003.
JP 5-0. Doctrine for Planning Joint Operations. 13 April 1995
Sequential traumatisation in children Results of a follow-up study by Hans Keilson
Abstract
In view of the variety of psychopathological, psychiatric-diagnostic and fundamental methodological questions in the medical recording and description of the condition of the survivors of Nazi terror, a man-made-disaster event of an extent of wickedness hitherto unknown in psychiatric traumatology, it seems to me not insignificant to begin with a few considerations with regard to the topic. Despite all the difficulties of integrating the biographical-anecdotal moment of a massively cumulative traumatised life course of adult persecutees into a superordinate system of a scientifically justifiable structure of thought, all the investigators, whatever theoretical presuppositions they followed, could start from the common principle that the elements of persecution, insofar as they were survived at all, represented and meant in their individual and in their entire experiential content an incursion into the “adult, mature personality”. What they represented and what they meant are the central problems that played a central and, as we all know, not always sublime role in reparation legislation and practice.
Ruiz-Hitzky, E., Darder, M., Wicklein, B., Ruiz-Garcia, C., Martín-Sampedro, R., del Real, G., & Aranda, P.. (2020). Nanotechnology Responses to COVID-19. Advanced Healthcare Materials
“Researchers, engineers, and medical doctors are made aware of the severity of the covid-19 infection and act quickly against the coronavirus sars-cov-2 using a large variety of tools. in this review, a panoply of nanoscience and nanotechnology approaches show how these disciplines can help the medical, technical, and scientific communities to fight the pandemic, highlighting the development of nanomaterials for detection, sanitation, therapies, and vaccines. sars-cov-2, which can be regarded as a functional core–shell nanoparticle (np), can interact with diverse materials in its vicinity and remains attached for variable times while preserving its bioactivity. these studies are critical for the appropriate use of controlled disinfection systems. other nanotechnological approaches are also decisive for the development of improved novel testing and diagnosis kits of coronavirus that are urgently required. therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. a brief overview on patented work is presented that emphasizes nanotechnology applied to coronaviruses. finally, some comments are made on patents of the initial technological responses to covid-19 that have already been put in practice.”
Yang, D.. (2021). Application of nanotechnology in the COVID-19 pandemic. International Journal of Nanomedicine
“COVID-19, caused by sars-cov-2 infection, has been prevalent worldwide for almost a year. in early 2000, there was an outbreak of sars-cov, and in early 2010, a similar dissemination of infection by mers-cov occurred. however, no clear explanation for the spread of sars-cov-2 and a massive increase in the number of infections has yet been proposed. the best solution to overcome this pandemic is the development of suitable and effective vaccines and therapeutics. fortunately, for sars-cov-2, the genome sequence and protein structure have been published in a short period, making research and develop- ment for prevention and treatment relatively easy. in addition, intranasal drug delivery has proven to be an effective method of administration for treating viral lung diseases. in recent years, nanotechnology-based drug delivery systems have been applied to intranasal drug delivery to overcome various limitations that occur during mucosal administration, and advances have been made to the stage where effective drug delivery is possible. this review describes the accumulated knowledge of the previous sars-cov and mers-cov infections and aims to help understand the newly emerged sars-cov-2 infection. furthermore, it elucidates the achievements in developing covid-19 vaccines and therapeutics to date through existing approaches. finally, the applicable nanotechnology approach is described in detail, and vaccines and therapeutic drugs developed based on nanomedicine, which are currently undergoing clinical trials, have presented the potential to become innovative alternatives for overcoming covid-19.”
Tharayil, A., Rajakumari, R., Chirayil, C. J., Thomas, S., & Kalarikkal, N.. (2021). A short review on nanotechnology interventions against COVID-19. Emergent Materials
“The covid-19 has affected all major aspects of the society in a global perspective. the role of nanotechnology is much sought after in fighting this pandemic. advanced materials based on nanotechnology are the basis of several technologies starting from masks and personal protection equipment to specific diagnostic tools that could diminish the impact of covid-19. development of nanotechnology-based products is therefore an absolute necessity for fight against covid-19. we examine the fundamental concepts related to virology, histopathologic findings and how nanotechnology can help in fighting the disease. in this review we discuss the state of the art and ongoing nanotechnology-based strategies like antiviral coatings, 3d printing and therapeutics to fight against this deadly disease. the importance of using nanoparticles in point of care tests and biosensors is also highlighted.”
Rasmi, Y., Saloua, K. S., Nemati, M., & Choi, J. R.. (2021). Recent progress in nanotechnology for covid-19 prevention, diagnostics and treatment. Nanomaterials
“The covid-19 pandemic is currently an unprecedented public health threat. the rapid spread of infections has led to calls for alternative approaches to combat the virus. nanotechnology is taking root against sars-cov-2 through prevention, diagnostics and treatment of infections. in light of the escalating demand for managing the pandemic, a comprehensive review that highlights the role of nanomaterials in the response to the pandemic is highly desirable. this review article comprehensively discusses the use of nanotechnology for covid-19 based on three main categories: prevention, diagnostics and treatment. we first highlight the use of various nanomaterials including metal nanoparticles, carbon-based nanoparticles and magnetic nanoparticles for covid-19. we critically review the benefits of nanomaterials along with their applications in personal protective equipment, vaccine development, diagnostic device fabrication and therapeutic approaches. the remaining key challenges and future directions of nanomaterials for covid-19 are briefly discussed. this review is very informative and helpful in providing guidance for developing nanomaterial-based products to fight against covid-19.”
Chauhan, G., Madou, M. J., Kalra, S., Chopra, V., Ghosh, D., & Martinez-Chapa, S. O.. (2020). Nanotechnology for COVID-19: Therapeutics and Vaccine Research. ACS Nano
“The current global health threat by the novel coronavirus disease 2019 (covid-19) requires an urgent deployment of advanced therapeutic options available. the role of nanotechnology is highly relevant to counter this ‘virus’ nano enemy. nano intervention is discussed in terms of designing effective nanocarriers to counter the conventional limitations of antiviral and biological therapeutics. this strategy directs the safe and effective delivery of available therapeutic options using engineered nanocarriers, blocking the initial interactions of viral spike glycoprotein with host cell surface receptors, and disruption of virion construction. controlling and eliminating the spread and reoccurrence of this pandemic demands a safe and effective vaccine strategy. nanocarriers have potential to design risk-free and effective immunization strategies for severe acute respiratory syndrome coronavirus 2 vaccine candidates such as protein constructs and nucleic acids. we discuss recent as well as ongoing nanotechnology-based therapeutic and prophylactic strategies to fight against this pandemic, outlining the key areas for nanoscientists to step in.”
Tang, Z., Zhang, X., Shu, Y., Guo, M., Zhang, H., & Tao, W.. (2021). Insights from nanotechnology in COVID-19 treatment. Nano Today
“In just a few months, sars-cov-2 and the disease it causes, covid-19, created a worldwide pandemic. virologists, biologists, pharmacists, materials scientists, and clinicians are collaborating to develop efficient treatment strategies. overall, in addition to the use of clinical equipment to assist patient rehabilitation, antiviral drugs and vaccines are the areas of greatest focus. given the physical size of sars-cov-2 and the vaccine delivery platforms currently in clinical trials, the relevance of nanotechnology is clear, and previous antiviral research using nanomaterials also supports this connection. herein we briefly summarize current representative strategies regarding nanomaterials in antiviral research. we focus specifically on sars-cov-2 and the detailed role that nanotechnology can play in addressing this pandemic, including i) using fda-approved nanomaterials for drug/vaccine delivery, including further exploration of the inhalation pathway; ii) introducing promising nanomaterials currently in clinical trials for drug/vaccine delivery; iii) designing novel biocompatible nanomaterials to combat the virus via interfering in its life cycle; and iv) promoting the utilization of nanomaterials in pneumonia treatment.”
Singh, Y. D., Ningthoujam, R., Panda, M. K., Jena, B., Babu, P. J., & Mishra, A. K.. (2021). Insight from nanomaterials and nanotechnology towards COVID-19. Sensors International
“The pandemic coronavirus disease 2019 (covid-19) becomes one of the most dreadful disease in the history of mankind in the entire world. the covid-19 outbreak started from wuhan city of china and then rapidly transmitted throughout the world causing mass destruction and seldom. this sporadical disease has taken many lives due to sudden outbreak and no particular vaccines were available at the early wave. all the vaccines developed are mostly targeted to spike protein of the virus which involves the encapsulation of mrna and nanoparticles. nanotechnology intervention in fighting against the covid-19 is one way to tackle the disease from different angles including nano coating mask, nano diagnostic kits, nano sanitizer, and nano medicine. this article highlights the intervention of nanotechnology and its possible treatment against the covid-19. it is high time to come together all the units of material science and biological science to fight against the dreadful covid-19. as an alternative strategy, a multidisciplinary research effort, consisting of classical epidemiology and clinical methodologies, drugs and nanotechnology, engineering science and biological apprehension, can be adopted for developing improved drugs exhibiting antiviral activities. the employment of nanotechnology and its allied fields can be explored to detect, treat, and prevent the covid-19 disease.”
Paliwal, P., Sargolzaei, S., Bhardwaj, S. K., Bhardwaj, V., Dixit, C., & Kaushik, A.. (2020). Grand Challenges in Bio-Nanotechnology to Manage the COVID-19 Pandemic. Frontiers in Nanotechnology
“The outbreak of the covid-19, a human beta coronavirus severe acute respiratory syndrome (sars-cov-2) virus infection, has severely affected the world. the pandemic is not yet in full control due to a lack of rapid diagnostics and therapeutics. this viral infection continues to result in a steadily increasing loss of life, and it has also emerged as a significant global socio-economic burden. as result, it has united many countries for the purposes of exploring molecular biology, biomedical science, and the nanotechnology to manage covid-19 successfully. as of today, the current priority is to investigate novel therapies of high efficacy and smart diagnostics tools for early-stage disease diagnostics along with monitoring. keeping these advancement and challenges in mind, this perspective article mainly highlights the contribution and possibilities of bio-nanotechnology to manage the covid-19 pandemic, even in a personalized manner. authors also pinpoint barriers to the utilization of current bio-nanotechnology to facilitate a more accurate understanding of covid-19 and to lead the way toward personalized health and wellness. furthermore, we follow the discussion of the features and challenges in upcoming bio-nanotechnology approaches for covid-19 management. in this progressive option report, bio-nanotechnologies that have been enriched with the power of artificial intelligence and optimized at the personalized level have been found to lead to a sustainable treatment and cure strategy at a global population scale.”
Campos, E. V. R., Pereira, A. E. S., De Oliveira, J. L., Carvalho, L. B., Guilger-Casagrande, M., De Lima, R., & Fraceto, L. F.. (2020). How can nanotechnology help to combat COVID-19? Opportunities and urgent need. Journal of Nanobiotechnology
“Incidents of viral outbreaks have increased at an alarming rate over the past decades. the most recent human coronavirus known as covid-19 (sars-cov-2) has already spread around the world and shown r0 values from 2.2 to 2.68. however, the ratio between mortality and number of infections seems to be lower in this case in comparison to other human coronaviruses (such as severe acute respiratory syndrome coronavirus (sars-cov) and middle east respiratory syndrome coronavirus (mers-cov)). these outbreaks have tested the limits of healthcare systems and have posed serious questions about management using conventional therapies and diagnostic tools. in this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of covid-19 and other viral infections. in this review, we discuss the use of nanotechnology for covid-19 virus management by the development of nano-based materials, such as disinfectants, personal protective equipment, diagnostic systems and nanocarrier systems, for treatments and vaccine development, as well as the challenges and drawbacks that need addressing.[figure not available: see fulltext.]”
Tavares, J. L., Cavalcanti, I. D. L., Santos Magalhães, N. S., & Lira Nogueira, M. C. de B.. (2022). Nanotechnology and COVID-19: quo vadis?. Journal of Nanoparticle Research
“The pandemic covid-19 has worried everyone due to the high mortality rate and the high number of people hospitalized with severe acute respiratory syndrome caused by sars-cov-2. given the seriousness of this disease, several companies and research institutions have sought alternative treatment and/or prevention methods for covid-19. due to its versatility, nanotechnology has allowed the development of protective equipment and vaccines to prevent the disease and reduce the number of severe covid-19 cases. thus, this article combined the main works and products developed in a nanotechnological field for covid-19. we performed a literature search using the keywords ‘covid-19,’ ‘sars-cov-2,’ ‘nanoparticles,’ ‘nanotechnology,’ and ‘liposomes’ in the scielo, scifinder, pubmed, sciencedirect, clinicaltrials, and nanotechnology products databases database. the data survey indicated 48 articles, 62 products, and 32 patents. the use of nanotechnology against covid-19 has brought benefits in several parameters of this disease, helping develop rapid diagnostic tests that release the result in 10 min, as well as developing vaccines containing genetic material from sars-cov-2 (dna, mrna, and protein subunits). nanotechnology is an exceptional ally against covid-19, contributing to the most diverse areas, helping both prevent, diagnose, and treat covid-19.”
Vahedifard, F., & Chakravarthy, K.. (2021). Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19. Emergent Materials
“Severe acute respiratory syndrome coronavirus 2 (sars-cov-2) has caused the recent outbreak of coronavirus 2019 (covid-19). although nearly two decades have passed since the emergence of pandemics such as sars-cov and middle east respiratory syndrome coronavirus (mers-cov), no effective drug against the cov family has yet been approved, so there is a need to find newer therapeutic targets. currently, simultaneous research across the globe is being performed to discover efficient vaccines or drugs, including both conventional therapies used to treat previous similar diseases and emerging therapies like nanomedicine. nanomedicine has already proven its value through its application drug delivery and nanosensors in other diseases. nanomedicine and its components can play an important role in various stages of prevention, diagnosis, treatment, vaccination, and research related to covid-19. nano-based antimicrobial technology can be integrated into personal equipment for the greater safety of healthcare workers and people. various nanomaterials such as quantum dots can be used as biosensors to diagnose covid-19. nanotechnology offers benefits from the use of nanosystems, such as liposomes, polymeric and lipid nanoparticles, metallic nanoparticles, and micelles, for drug encapsulation, and facilitates the improvement of pharmacological drug properties. antiviral functions for nanoparticles can target the binding, entry, replication, and budding of covid-19. the toxicity-related inorganic nanoparticles are one of the limiting factors of its use that should be further investigated and modified. in this review, we are going to discuss nanomedicine options for covid-19 management, similar applications for related viral diseases, and their gap of knowledge.”
Singh, P., Singh, D., Sa, P., Mohapatra, P., Khuntia, A., & Sahoo, S. K.. (2021). Insights from nanotechnology in COVID-19: Prevention, detection, therapy and immunomodulation. Nanomedicine
“The outbreak of sars-cov-2 infection has presented the world with an urgent demand for advanced diagnostics and therapeutics to prevent, treat and control the spread of infection. nanotechnology seems to be highly relevant in this emergency due to the unique physicochemical properties of nanomaterials which offer versatile chemical functionalization to create advanced biomedical tools. here, nano-intervention is discussed for designing effective strategies in developing advanced personal protective equipment kits, disinfectants, rapid and cost-effective diagnostics and therapeutics against the infection. we have also highlighted the nanoparticle-based vaccination approaches and how nanoparticles can regulate the host immune system against infection. overall, this review discusses various nanoformulations that have shown clinical relevance or can be explored in the fight against covid-19.”
Hasanzadeh, A., Alamdaran, M., Ahmadi, S., Nourizadeh, H., Bagherzadeh, M. A., Mofazzal Jahromi, M. A., … Hamblin, M. R.. (2021). Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies. Journal of Controlled Release
“The emergence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) in early 2020 soon led to the global pandemic of coronavirus disease 2019 (covid-19). since then, the clinical and scientific communities have been closely collaborating to develop effective strategies for controlling the ongoing pandemic. the game-changing fields of recent years, nanotechnology and nanomedicine have the potential to not only design new approaches, but also to improve existing methods for the fight against covid-19. nanomaterials can be used in the development of highly efficient, reusable personal protective equipment, and antiviral nano-coatings in public settings could prevent the spread of sars-cov-2. smart nanocarriers have accelerated the design of several therapeutic, prophylactic, or immune-mediated approaches against covid-19. some nanovaccines have even entered phase iι/iiι clinical trials. several rapid and cost-effective covid-19 diagnostic techniques have also been devised based on nanobiosensors, lab-on-a-chip systems, or nanopore technology. here, we provide an overview of the emerging role of nanotechnology in the prevention, diagnosis, and treatment of covid-19.”
Weiss, C., Carriere, M., Fusco, L., Fusco, L., Capua, I., Regla-Nava, J. A., … Delogu, L. G.. (2020). Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic. ACS Nano
“The covid-19 outbreak has fueled a global demand for effective diagnosis and treatment as well as mitigation of the spread of infection, all through large-scale approaches such as specific alternative antiviral methods and classical disinfection protocols. based on an abundance of engineered materials identifiable by their useful physicochemical properties through versatile chemical functionalization, nanotechnology offers a number of approaches to cope with this emergency. here, through a multidisciplinary perspective encompassing diverse fields such as virology, biology, medicine, engineering, chemistry, materials science, and computational science, we outline how nanotechnology-based strategies can support the fight against covid-19, as well as infectious diseases in general, including future pandemics. considering what we know so far about the life cycle of the virus, we envision key steps where nanotechnology could counter the disease. first, nanoparticles (nps) can offer alternative methods to classical disinfection protocols used in healthcare settings, thanks to their intrinsic antipathogenic properties and/or their ability to inactivate viruses, bacteria, fungi, or yeasts either photothermally or via photocatalysis-induced reactive oxygen species (ros) generation. nanotechnology tools to inactivate sars-cov-2 in patients could also be explored. in this case, nanomaterials could be used to deliver drugs to the pulmonary system to inhibit interaction between angiotensin-converting enzyme 2 (ace2) receptors and viral s protein. moreover, the concept of ‘nanoimmunity by design’can help us to design materials for immune modulation, either stimulating or suppressing the immune response, which would find applications in the context of vaccine development for sars-cov-2 or in counteracting the cytokine storm, respectively. in addition to disease prevention and therapeutic potential, nanotechnology has important roles in diagnostics, with potential to support the development of simple, fast, and cost-effective nanotechnology-based assays to monitor the presence of sars-cov-2 and related biomarkers. in summary, nanotechnology is critical in counteracting covid-19 and will be vital when preparing for future pandemics.”
Rangayasami, A., Kannan, K., Murugesan, S., Radhika, D., Sadasivuni, K. K., Reddy, K. R., & Raghu, A. V.. (2021). Influence of nanotechnology to combat against COVID-19 for global health emergency: A review. Sensors International
“Covid 2019 is spreading and emerging rapidly all over the world as a new social disaster. this virus is accountable for the continuous epidemic that causes severe respiratory problems and pneumonia related to contamination of humans, which leads to a dangerous condition of life. due to the increasing threatening number of cases all over the world, the world health organization (who) declared coronavirus as a global health emergency. the pandemic disease affected nearly 80 million people positive cases were reported worldwide till now and cause the death of more than 1.7 million people. the virus has novel characteristics types of pathogens. many clarifications are done and much more are still unknown and pending. the collaborative research will be useful during this pandemic time in order to meet the improvement of global health improvement. it will also help to know about the knowledge of this covid-19. recent advancements in nanotechnology proved that they can help in the production of vaccines in a brief timeframe. in this review, the requirement for quick immunization improvement and the capability and implementation of nanotechnology combat against coronavirus disease were discussed.”
Chintagunta, A. D., Sai Krishna, M., Nalluru, S., & Sampath Kumar, N. S.. (2021). Nanotechnology: an emerging approach to combat COVID-19. Emergent Materials
“The recent outbreak of coronavirus disease (covid-19) has challenged the survival of human existence in the last 1 year. frontline healthcare professionals were struggling in combating the pandemic situation and were continuously supported with literature, skill set, research activities, and technologies developed by various scientists/researchers all over the world. to handle the continuously mutating severe acute respiratory syndrome coronavirus-2 (sars-cov-2) requires amalgamation of conventional technology with emerging approaches. nanotechnology is science, engineering, and technology dealing at the nanoscale level. it has made possible the development of nanomaterials, nano-biosensors, nanodrugs, and vaccines for diagnosis, therapy, and prevention of covid-19. this review has elaborately highlighted the role of nanotechnology in developing various detection kits such as nanoparticle-assisted diagnostics, antibody assay, lateral flow immunoassay, nanomaterial biosensors, etc., in detection of sars-cov-2. similarly, various advancements supervene through nanoparticle-based therapeutic drugs for inhibiting viral infection by blocking virus attachment/cell entry, multiplication/replication, and direct inactivation of the virus. furthermore, information on vaccine development and the role of nanocarriers/nanoparticles were highlighted with a brief outlining of nanomaterial usage in sterilization and preventive mechanisms engineered to combat covid-19 pandemic.”
Cardoso, V. M. de O., Moreira, B. J., Comparetti, E. J., Sampaio, I., Ferreira, L. M. B., Lins, P. M. P., & Zucolotto, V.. (2020). Is Nanotechnology Helping in the Fight Against COVID-19?. Frontiers in Nanotechnology
“The novel coronavirus disease (covid-19) pandemic represents an unprecedented public health concern. the disease, which has an incredibly high spreading rate, was discovered in late december 2019, in wuhan, hubei province, china. the virus that causes covid-19, known as severe acute respiratory syndrome coronavirus 2 (sars-cov-2), is responsible for the infection of more than 21.8 million individuals and more than 772 thousand deaths in 216 countries, numbers which are still rising. currently, there are no vaccines or antiviral treatments officially approved for the prevention or treatment of covid-19. since its appearance, several therapeutic approaches have been tested, including the use of repurposing drugs, such as broad-spectrum antivirals, nucleoside analogs, protease inhibitors, immunomodulators, and plasma therapies, among others. however, these strategies have not shown great clinical benefits and are only administered to attenuate the symptoms. although many therapeutic strategies are being tested against covid-19, more efforts should be devoted to fighting the virus. nanomaterials represent a powerful tool against covid-19 since they can be designed to act directly toward the infection, increase the effectiveness of conventional antiviral drugs, or even to trigger the immune response of the patient. advances in nanotechnology over the past decades allow us to develop new nanomaterials and step forward in the application of new technological tools. this review addresses aspects related to the structural characteristics of the virus, the mechanisms involved in the infection, and therapies that are currently used against covid-19. this review discusses nanotechnology-based strategies for the prevention, diagnosis, and treatment of covid-19, including nanomaterials for face masks and surface sterilization, adjuvants, vaccine delivery nanosystems, and point-of-care tests, providing a perspective on how nanotechnology could be an applied in the fight against covid-19.”
Tavakol, S., Zahmatkeshan, M., Mohammadinejad, R., Mehrzadi, S., Joghataei, M. T., Alavijeh, M. S., & Seifalian, A.. (2021). The role of nanotechnology in current COVID-19 outbreak. Heliyon
“COVID-19 has recently become one of the most challenging pandemics of the last century with deadly outcomes and a high rate of reproduction number. it emphasizes the critical need for the designing of efficient vaccines to prevent virus infection, early and fast diagnosis by the high sensitivity and selectivity diagnostic kits, and effective antiviral and protective therapeutics to decline and eliminate the viral load and side effects derived from tissue damages. therefore, non-toxic antiviral nanoparticles (nps) have been under development for clinical application to prevent and treat covid-19. nps showed great promise to provide nano vaccines against viral infections. here, we discuss the potentials of nps that may be applied as a drug itself or as a platform for the aim of drug and vaccine repurposing and development. meanwhile, the advanced strategies based on nps to detect viruses will be described with the goal of encouraging scientists to design effective and cost-benefit nanoplatforms for prevention, diagnosis, and treatment.”
Du, L., Yang, Y., Zhang, X., & Li, F.. (2022). Recent advances in nanotechnology-based COVID-19 vaccines and therapeutic antibodies. Nanoscale
“COVID-19 has caused a global pandemic and millions of deaths. it is imperative to develop effective countermeasures against the causative viral agent, sars-cov-2 and its many variants. vaccines and therapeutic antibodies are the most effective approaches for preventing and treating covid-19, respectively. sars-cov-2 enters host cells through the activities of the virus-surface spike (s) protein. accordingly, the s protein is a prime target for vaccines and therapeutic antibodies. dealing with particles with dimensions on the scale of nanometers, nanotechnology has emerged as a critical tool for rapidly designing and developing safe, effective, and urgently needed vaccines and therapeutics to control the covid-19 pandemic. for example, nanotechnology was key to the fast-track approval of two mrna vaccines for their wide use in human populations. in this review article, we first explore the roles of nanotechnology in battling covid-19, including protein nanoparticles (for presentation of protein vaccines), lipid nanoparticles (for formulation with mrnas), and nanobodies (as unique therapeutic antibodies). we then summarize the currently available covid-19 vaccines and therapeutics based on nanotechnology. this journal is”
Chaudhary, V., Royal, A., Chavali, M., & Yadav, S. K.. (2021). Advancements in research and development to combat COVID-19 using nanotechnology. Nanotechnology for Environmental Engineering
“The whole world is currently facing a global health crisis due to the coronavirus disease (covid-19) pandemic caused by sars coronavirus 2, which started in wuhan city, china, in december 2019. the pandemic has affected 235 countries, areas or territories and infected over 42 million people across the globe as per who update on 27 october 2020. more than 1.1 million people have died and the numbers are increasing daily. however, some drugs have been authorized for emergency treatment of patients, medication and vaccines with proven efficacy to prevent and treat the disease is still under various phases of development. the entire world is consistently making efforts to address three major challenges related to covid-19 including prevention of its spread, prompt and early diagnosis and treatment of patients to save lives. touted as one of the game-changing technologies of the century, nanotechnology has huge potential to develop solutions against these three major challenges of the disease. nanotechnology comprises of multidisciplinary prospects encompassing diverse disciplines including medicine, material science, artificial intelligence, environment, virology, physical sciences, chemistry and biology. the numerous challenges can be addressed through the engineering of the various physicochemical properties of materials presents in abundance in nature. various claims, studies and reports on research and development to combat these challenges associated with covid-19 have been collectively discussed in this article from the perspectives of nanotechnology.”
Rai, M., Bonde, S., Yadav, A., Bhowmik, A., Rathod, S., Ingle, P., & Gade, A.. (2021). Nanotechnology as a shield against covid-19: Current advancement and limitations. Viruses
“The coronavirus disease 2019 (covid-19) caused by severe acute respiratory syndrome coronavirus 2 (sars-cov-2) is a global health problem that the who declared a pandemic. covid19 has resulted in a worldwide lockdown and threatened to topple the global economy. the mortality of covid-19 is comparatively low compared with previous sars outbreaks, but the rate of spread of the disease and its morbidity is alarming. this virus can be transmitted human-to-human through droplets and close contact, and people of all ages are susceptible to this virus. with the advancements in nanotechnology, their remarkable properties, including their ability to amplify signal, can be used for the development of nanobiosensors and nanoimaging techniques that can be used for early-stage detection along with other diagnostic tools. nano-based protection equipment and disinfecting agents can provide much-needed protection against sars-cov-2. moreover, nanoparticles can serve as a carrier for antigens or as an adjuvant, thereby making way for the development of a new generation of vaccines. the present review elaborates the role of nanotechnology-based tactics used for the detection, diagnosis, protection, and treatment of covid-19 caused by the sars-cov-2 virus.”
Dube, A., Egieyeh, S., & Balogun, M.. (2021). A perspective on nanotechnology and covid-19 vaccine research and production in south africa. Viruses
“Advances in nanotechnology have enabled the development of a new generation of vaccines, which are playing a critical role in the global control of the covid-19 pandemic and the return to normalcy. vaccine development has been conducted, by and large, by countries in the global north. south africa, as a major emerging economy, has made extensive investments in nanotechnology and bioinformatics and has the expertise and resources in vaccine development and manufacturing. this has been built at a national level through decades of investment. in this perspective article, we provide a synopsis of the investments made in nanotechnology and highlight how these could support innovation, research, and development for vaccines for this disease. we also discuss the application of bioinformatics tools to support rapid and cost-effective vaccine development and make recommendations for future research and development in this area to support future health challenges.”
Tyagi, P. K., Tyagi, S., Kumar, A., Ahuja, A., & Gola, D.. (2021). Contribution of nanotechnology in the fight against covid-19. Biointerface Research in Applied Chemistry
“Coronavirus disease (covid-19) is a respiratory infectious disease caused by a newly discovered virus strain, severe acute respiratory syndrome coronavirus-2 (sars-cov-2). this pandemic spread quickly across nations with a high mortality rate in immunocompromised patients. this contagious disease posed a serious threat to health systems. it impacted the continents of the earth in a way that could not have been predicted. therefore, many leading funding agencies announced the call for proposal to diagnosis and treatment of covid-19 pandemic using advanced technology-based methods, including nanotechnology. the researchers coming from the nanotechnology community can contribute their efforts to cope with covid-19. as a community member of nanotechnology, we suggest some new research targets that can be designed and improved, optimized, and developed the existing/new materials in the sub-field of diagnostics and healthcare of nanotechnology. the potential research targets to fight against covid-19 includes point-of-care diagnostics (pocd), surveillance and monitoring, novel therapeutics, vaccine development, research, and development, repurposing existing drugs with potential therapeutic applications, development of antiviral nanocoating/antimicrobial spray-based coating for ppe, magnetic nanoparticles and viral rna and rapid detection kits.”
De M Ribeiro, L. N., & Fonseca, B. B.. (2020). The role of pharmaceutical nanotechnology in the time of COVID-19 pandemic. Future Microbiology
“There is no effective therapy against covid-19 available so far. in the last months, different drugs have been tested as potential treatments for covid-19, exhibiting high toxicity and low efficacy. therefore, nanotechnology can be applied to improve the therapeutic action and minimize the toxicity of loaded drugs. in this review, we summarized the drugs tested as covid-19 treatment and the advantages of antiviral nanostructured drug-delivery systems. such systems have demonstrated low in vitro toxicity with better in vitro antiviral activity than free drugs. we believe that this approach should inspire novel nanostructured drug-delivery systems developments to find efficient covid-19 treatments. here, we discuss the remaining challenges for such promising nanosystems to be approved for clinical use.”
Chung, Y. H., Beiss, V., Fiering, S. N., & Steinmetz, N. F.. (2020). Covid-19 vaccine frontrunners and their nanotechnology design. ACS Nano
“Humanity is experiencing a catastrophic pandemic. sars-cov-2 has spread globally to cause significant morbidity and mortality, and there still remain unknowns about the biology and pathology of the virus. even with testing, tracing, and social distancing, many countries are struggling to contain sars-cov-2. covid-19 will only be suppressible when herd immunity develops, either because of an effective vaccine or if the population has been infected and is resistant to reinfection. there is virtually no chance of a return to pre-covid-19 societal behavior until there is an effective vaccine. concerted efforts by physicians, academic laboratories, and companies around the world have improved detection and treatment and made promising early steps, developing many vaccine candidates at a pace that has been unmatched for prior diseases. as of august 11, 2020, 28 of these companies have advanced into clinical trials with moderna, cansino, the university of oxford, biontech, sinovac, sinopharm, anhui zhifei longcom, inovio, novavax, vaxine, zydus cadila, institute of medical biology, and the gamaleya research institute having moved beyond their initial safety and immunogenicity studies. this review analyzes these frontrunners in the vaccine development space and delves into their posted results while highlighting the role of the nanotechnologies applied by all the vaccine developers.”
Identity politics is a political approach wherein people of a particular race, religion, gender, social background, social class, environmental, or other identifying factors develop political agendas that are based upon these identities. Such groups often have support from allies outside the respective identity groups.
The laden phrase “identity politics” has come to signify a wide range of political activity and theorizing founded in the shared experiences of injustice of members of certain social groups. Rather than organizing solely around belief systems, programmatic manifestos, or party affiliation, identity political formations typically aim to secure the political freedom of a specific constituency marginalized within its larger context. Members of that constituency assert or reclaim ways of understanding their distinctiveness that challenge dominant characterizations, with the goal of greater self-determination.
“We review the literature on the rise of identity politics and populism in europe. populist parties have gained large vote shares since the great recession of 2008. we observe in many countries, and even in the european parliament, a transformation of the main dimension of politics from the left-right cleavage to a new cleavage opposing the mainstream parties to populist parties. we examine how this transformation relates to changes in voter attitudes and the adjustment of political parties to these changes. two main types of causes for the rise of populism have emerged: economic and cultural. in reviewing the evidence, we find a complex interaction between economic and cultural factors. economic anxiety among large groups of voters related to the great recession and austerity policies triggers a heightened receptivity to the messages of cultural backlash from populist parties.”
Sawitri, M. Y., & Wiratmaja, I. N.. (2021). On the brink of post-democracy: Indonesia’s identity politics in the post-truth era. Politicka Misao
“As a country with a diversity of languages, religions, ethnicities and cultures, indonesia is particularly vulnerable to the hostile play of identity politics. lies produced during the post-truth period exploit many emotional sentiments and provoke interest groups to act based on primordial impulses that support certain political interests. the negative turbulence related to identity politics due to the chaotic circulation of hoaxes and misinformation is feared to lead to a post-democratic situation. taking the case study of the two most influential elections in indonesia: the 2017 jakarta provincial election and the 2019 presidential election, this paper will explore how the post-truth phenomenon incorporates the issue of identity politics to generate a post-democratic situation in indonesia. secondary data analysis from the news and social media will be employed to further explain how identity politics is distorted in the media, and how it can generate social and political turbulence.”
Moran, M.. (2020). (Un)troubling identity politics: A cultural materialist intervention. European Journal of Social Theory
“This article draws on the cultural materialist paradigm articulated by raymond williams to offer a radical historicization of the idea of identity, with a view to clarifying and resolving some of the issues animating the ‘identity politics’ debates currently dividing left academia and activism. first, it offers clarity on the concept ‘identity politics’, demonstrating that we should reserve the term to refer only to politics that mobilize specifically and meaningfully around the concept of identity. second, and in virtue of this, it provides new insights into five central questions that have driven the identity politics debates: do identity politics always tend towards essentialism?; do identity politics inevitably promote a politics of recognition over redistribution?; do identity politics inevitably create political cleavages rather than solidaristic forms of political action?; what is the relationship between ‘identity politics’ and ‘call-out culture’?; and, are the problems of identity politics resolved by reference to intersectionality?”
Béland, D.. (2017). Identity, politics, and public policy. Critical Policy Studies
“Although much has been written about ‘identity politics’ in the narrow sense of the term, students of politics and public policy can take a more systematic look at the connection between identity and politics, as related to public policy. this essay shows that, by putting identity at the center of their analysis of politics and public policy, scholars can gain powerful insight about both explanation and policy prescription. in other words, how actors understand themselves and are seen by others are key aspects of political and policy analysis and they each deserve a systematic and interdisciplinary treatment. the essay suggests this by drawing on recent social science literature, such as identity economics, to explore the relevance of the connection between identity and politics for policy research across different policy areas and regions of the world. because several of these literatures are seldom discussed together, this essay offers a particularly broad and multi-faceted identity perspective for the analysis of politics and public policy.”
Brunila, K., & Rossi, L. M.. (2018). Identity politics, the ethos of vulnerability, and education. Educational Philosophy and Theory
“In this article, identity politics is understood as a form of politics stressing collective but malleable group identities as the basis of political action. this notion of identity politics also allows thinking of identity as intersectional. the focus of this article, and a problem related to identity politics, is that when discussed in the context of the neoliberal order, identity politics has a tendency to become harnessed by the ethos of vulnerability. some implications of the ‘vulnerabilizisation’ are considered in the field of education, which is a field currently thoroughly affected by neoliberalism. therefore, it is also important to look closer at the relationship between identity politics and the ethos of vulnerability. in addition, we re-consider poststructuralist thinking as a theoretical and political approach to see what it can offer in terms of re-thinking identity politics and in analyzing the ethos of vulnerability. when categories of vulnerability keep expanding into various psycho-emotional vulnerabilities defining subjects that can be known and spoken about, it is crucial to ask whether we regard these changes as educationally and politically progressive. the article discusses some problematic policies in educational environments and the phenomenon of trigger warnings.”
Paul, J.. (2019). ‘Not Black and White, but Black and Red’: Anti-identity identity politics and #AllLivesMatter. Ethnicities
“This article critically examines #alllivesmatter, which emerged as a rebuttal to #blacklivesmatter, arguing, in spite of its universalist pretentions, that it represents a cloaked identitarian politics which through a hegemonic narrative (re)presents itself as a radically inclusionary counter-narrative. i argue all lives matter exemplifies an anti-identity identity politics by invoking rhetoric in opposition to racial identities while smuggling in a somewhat elastic ‘postracial’ neoliberal subject as the foundational identity around which this new mobilisation is organised. the article outlines a definition for anti-identity identity politics and uses this as a lens for analysing all lives matter in order to interrogate this keyword.”
Purdeková, A., & Mwambari, D.. (2022). Post-genocide identity politics and colonial durabilities in Rwanda. Critical African Studies
“While academic literature has long explored the ways in which colonial reification of identity and narratives underpinning unequal racialised status of colonial subjects contributed to cycles of violence in the great lakes region, including in rwanda, few ask the complementary question: does the colonial legacy imprint on the ‘post-conflict’ era, shaping post-genocide attempts at nation-building and identity re-engineering carried out in the name of the broader project of peacebuilding? using the conceptual framework of colonial durabilities, we argue that despite explicit attempts to remove the vestiges of colonialism, the colonial past endures, in everyday expressions of identity as well as in grand policies of its reformulation. the current paper aims to trace these vestiges in the transformations of identity politics and nation-building in rwanda by looking at three distinct arenas: (i) the architecture of de-ethnicisation policy itself; (ii) the stubborn lingering of racialised distinctions in popular culture; and (iii) the rise of ‘new’ social divisions based on the country of exile.”
Lefaan, A.. (2021). Identity Politics And The Future Of Democracy In Papua. Journal of Legal, Ethical and Regulatory Issues
Show/hide publication abstract
“Although the same phenomenon also occurs in other areas, in papua, the practice of identity politics presents an interesting political phenomenon, because what is happening is a tug of war between the two groups of essentialistic identities among the papuans themselves, namely between mount papua and coastal papua. the issue of local identity politics is so strong that even it is more imprinted on the mental structure of the papuanese. the issue becomes stronger in every political moment of regional elections (pilkada). for example, in the 2018 simultaneous regional elections, the battle for the identity between papuanese living in the mountains (papua gunung) and papuanese living in coastal areas (papua pantai) reemerged. on that basis, the governor candidate pairs considered the configuration of this identity politics. this trend is getting stronger, especially when the representative of papua gunung won the 2014 papua gubernatorial election (pilgub). in subsequent political developments, the practice of identity politics continues to dominate political dynamics in papua. in the 2018 simultaneous regional elections, the phenomenon of identity politics was practiced by several elites to fight for power and gain strength. as an illustration, the configuration of the governor candidates proposed by several political parties in the 2018 papua gubernatorial election shows the dichotomy configuration of the identity of papua pantai and papua gunung. johm wetipo and habel suwae, for example, wetipo is from papua gunung, namely the wamena regent; while habel melkias suwae is from papua pantai, the former regent of jayapura regency. likewise, another candidate pair, lukas enembe and klemen tinal in which lukas is from papua gunung, and klementinal is a person from papua pantai. this phenomenon certainly has implications for the quality of democracy substantially. simultaneous regional elections are a manifestation of a democratic political system, so selecting political leadership is based more on the prospective leader’s professional ability and capacity. the thesis that can be put forward is that a democratic system provides the broadest possible opportunity for anyone to become a leader as long as they have the capacity to do so. so leaders are elected by the people through democratic mechanisms because of professionalism, not because of primordialism aspects such as ethnicity, religion and race, or other permanently attached identities. this short article …”
Hess, J.. (2019). Singing our own song: Navigating identity politics through activism in music. Research Studies in Music Education
“This work builds upon considerations of musicking that suggest processes of performing, creating, listening, and producing of music are sites for identity formation and meaning-making activities. in this project, i interviewed 20 activist-musicians about the following dimensions of identity and meaning-making in their work: (a) how they view the role of (their) music; (b) how they situate themselves in their work; and (c) what they believe are the implications of their work for music education, based on (d) their own experiences of music. i draw on said’s counterpoint as an analytical tool to hold conflicting identities and issues in tension without false resolution. significantly, the majority of the activist-musicians who participated in the study saw music not only as a means of identity formation, but also as a site to engage in, express, and formulate identity politics. together, these elements have substantive implications for music education. in imagining an activist school music education, music may enable students to navigate the politics of identity, opening up possibilities to embrace, trouble, and explore the intersections of identity. this article concludes with implications for pedagogy and curriculum in school music education and the consideration of composing as a dual act—an act of formulating identity and a musical act of assertion.”
Bernstein, M.. (2005). Identity politics. Annual Review of Sociology
“This paper studies the effects of cultural identity on electoral and policy outcomes when voters are ‘behavioral.’ building on the evidence that voters assess political or economic events through the lens of their partisan identifications, we analyze an election between two office-motivated candidates in which voters over-reward or under-punish the candidate that shares their cultural identity. focusing on issues with cultural as well as distributional implications for voters such as immigration and the cultural divide based on nativism as the source of identity politics, we find that the candidates’ equilibrium policies are always preferred by the electorally dominant cultural group to the policy that would be optimal if policies only had distributional consequences. we also show that candidates do not necessarily target their own cultural bases in equilibrium. furthermore, stronger identity politics increases policy polarization. our findings contribute to the debates on the decoupling of voting behavior from economic interests, and the rise of immigration, trade protectionism, or engagement with global governing institutions as electoral issues that can shift historical voting patterns.”
Kumar, A., Elliott-Cooper, A., Iyer, S., & Gebrial, D.. (2018). An introduction to the special issue on identity politics. Historical Materialism
“This special issue responds to ongoing debates around what has been termed ‘identity politics’. we aim to intervene in what are make-or-break questions for the left today. specifically, we wish to provoke further interrogative but comradely conversation that works towards breaking-down the wedge between vulgar economism and vulgar culturalism. critically, we maintain that just as all identity categories are spatially and temporally contingent-socially constructed, yet naturalised-so too is this current bifurcation between ‘class politics’ and ‘identity politics’. ultimately, we call for an intellectual and organisational embracing of the complexity of identity as it figures in contemporary conditions; being a core organising-principle of capitalism as it functions today, a paradigm that leftist struggle can be organised through and around- a nd yet all with a recognition of the necessity of historicising, and ultimately abolishing, these categories along with capitalism itself.”
Gin, W.. (2021). Divided by Identity on the Left? Partisan Spillover and Identity Politics Alignment. Forum (Germany)
“It has often been stated that in the united states the left tends to be less united than the right on issues related to identity politics such as race, gender, and religion. this article presents evidence that this asymmetry in partisan alignment over identity politics is changing over time. looking at various measures of public opinion shows that the left’s agreement on issues related to identity politics has either caught up with the right or that the gap is diminishing. the article considers various possible explanations for unity on these issues – including personality distribution, party homogeneity, and message infrastructure – and shows that partisan spillover in the context of polarization helps explains the closing of the gap in unity between the right and the left. in an era of polarization, democratic affiliation induces warmer feeling toward stigmatized coalition partners. groups that may have joined the democratic party on a single group interest claim (race, gender, religion, class) will gradually move toward greater acceptance of other group interest claims supported by the party. these findings have implications for the oft-stated strategic claim that the left needs to focus on class redistribution over identity politics if the left does not want to be fractured.”
Bliss, C.. (2013). The Marketization of Identity Politics. Sociology
Prieto, M.. (2022). Indigenous Resurgence, Identity Politics, and the Anticommodification of Nature: The Chilean Water Market and the Atacameño People. Annals of the American Association of Geographers
“What is ‘uncooperative’ about the commodification of nature? this article argues that critical understandings of neoliberal environmental governance must contend with complex processes of identity formation and mobilization. drawing on an analysis of water rights formalization in chile, widely seen as the most radical case of water commodification in the world, this article demonstrates how indigenous identity works to subvert the processes and politics of commodifying water. a growing body of recent literature (mainly in the andes) has emphasized the relationship between water control and indigenous resurgence, stressing how indigeneity can disrupt neoliberalism. following this approach, and through analyzing oral testimonies from atacameño people, i highlight the atacameños’ agency throughout the implementation of the chilean water model in the atacama desert. by studying the atacameños’ perceptions of the intimate relationship between water, power, and identity politics in their desert homeland, i conclude that the chilean water model, rather than posing a threat to a genuine identity, has allowed for the articulation of a legitimate indigenous positionality for the purpose of retaining a collective hydraulic property. the results provide a more comprehensive understanding of the contradictions of the chilean case and the role of identity politics within the commodification of natural processes.”
Wilhelmsen, F.. (2021). “The Wife Would Put on a Nice Suit, Hat, and Possibly Gloves”: The Misogynistic Identity Politics of Anders Behring Breivik. Fascism
“By analysing the anti-feminist and misogynistic narratives in anders behring breivik’s compendium 2083: a european declaration of independence, this article argues that breivik’s counterjihadist worldview can be located both as a permutation of ‘generic fascism’ and as a form of nonegalitarian ‘identity politics’. first, the article reframes and reformulates nancy fraser’s concept of identity politics, as it sets breivik’s ideology in relation to her theory of a ‘politics of recognition’, arguing that her theories – originally developed to analyse left-wing politics – can be used to identify how questions of identity are at the centre of the dynamics of breivik’s far-right ideology. the article then goes on to demonstrate how breivik’s misogynist narratives are plotted into a broader fascist conception of history, where the alleged feminised and islamised present is described as an estrangement from a glorious past dominated by white, european men. as a result, breivik’s futural palingenetic vision of a ‘European cultural renaissance’ is not only going to resurrect a white, homogenous, ‘christian’ society, but also restore patriarchy.”
Kumar, P.. (2018). Rerouting the Narrative: Mapping the Online Identity Politics of the Tamil and Palestinian Diaspora. Social Media and Society
“Drawing on the e-diasporas atlas project (www.e-diasporas.fr) and original empirical research, this study examines the complex role of the world wide web in supporting and enabling new types of diaspora identity politics. it compares the online identity politics of two conflict-generated diasporas: tamils and palestinians. both of these stateless diaspora communities maintain a strong web presence and have mobilized around various secessionist attempts, grievance narratives, issue-agendas, and calls for the right to self-determination that have garnered significant attention from the international community and mainstream media in recent times. analytical concepts from transnational advocacy networks (tans) and social movement literature are used to draw attention to the dynamic identity-based processes and framing mechanisms that connect diasporic demands and political claims across online and offline environments. the data combine tamil and palestinian e-diasporas hyperlink network maps with web-based content analysis and key respondent interviews. the study argues that online diasporic exchanges transcend host–homeland territorial boundaries and invite comparatively expressive forms of identity-based political engagements that are simultaneously both deeply local and digitally global. in particular, the analysis demonstrates that human rights–based language offers a unique streamlining bridge between various locales, countries of settlement, and the international system more broadly.”
Böschen, S., Legris, M., Pfersdorf, S., & Stahl, B. C.. (2020). Identity Politics: Participatory Research and Its Challenges Related to Social and Epistemic Control. Social Epistemology
“Over the past 20 years, the participation of laypersons or representatives of civil society has become a guiding principle in processes of research and innovation. there is now a significant literature discussing collaboration between civil society organisations (csos) and researchers, with two interesting gaps. firstly, the fact that research is mainly conducted within projects is often underestimated, although the format significantly frames knowledge production. secondly, researchers and civil society organisations are closely related to their respective communities. we argue that this constellation–of project-related format, in combination with a strong relationship to communities–results in conflicts that express and lead to identity politics. the analysis is based on conceptual considerations as well as empirical findings, which were developed within the ec-funded consider project (2012–2015). it can be shown that identity politics is performed by socio-epistemic tactics, which are used to order the socially as well as epistemically hybrid space within projects. to explain differences in conflict intensity, we suggest the distinction between weakly tied and strongly tied identity politics. in sum, identity politics can be seen as one key element for social as well as epistemic control in transdisciplinary research projects.”
Chubin, F.. (2020). From Empowerment to Advocacy: Innominate Identity Politics as Feminist Advocacy in Iran. International Journal of Politics, Culture and Society
“Through in-depth interviews and ethnographic observation of a nongovernmental organization in iran dedicated to advocacy for marginalized women, i demonstrate that in the absence of political opportunity for ‘rights’ advocacy in iran, unconventional modes of identity politics have emerged. my data suggest that some practices of identity politics in iran depart in framing, strategy, and organization from conventional practices of identity politics prevalent in liberal democratic contexts where identities are invoked, deployed, and tied to a universal conception of ‘rights.’ i introduce the term ‘innominate identity politics’ to reveal a creative utilization of the framework of ‘capabilities’ for identity-based advocacy where ‘rights’ advocacy and group identity formation are not tolerated by the government. identities, hence, are innominate (unnamed), yet fought for. this article explains the organization’s departure from the common practices of identity politics by examining three factors which necessitated the adoption of new frames and strategies: (1) the repressive politics of the state which had rendered the ‘rights’ framework costly and inaccessible, (2) the social construction of the organization’s clients as ‘bare life’ due to the intersection of multiple systems of inequality, and (3) the social actors’ perception of what constitutes effective advocacy.”
Vaara, E., Tienari, J., & Koveshnikov, A.. (2021). From Cultural Differences to Identity Politics: A Critical Discursive Approach to National Identity in Multinational Corporations. Journal of Management Studies
“There is a paucity of knowledge of one key aspect of diversity in and around international organizations: national identity. this is especially the case with research on multinational corporations (mnc) that has focused on cultural differences instead of processes of national identification or national identity construction. drawing on a critical discursive approach, this paper offers four perspectives that can help to advance this area of research. first, mncs can be viewed as sites of identity politics, within which one can study ‘us vs. them’ constructions and the reproduction of inequalities. second, mncs can be seen as actors engaged in identity building and legitimation vis-à-vis external stakeholders, and the analysis of the discursive dynamics involved illuminates important aspects of identity politics between the organization and its environment. third, mncs can be viewed as part of international relations between nations and nationalities, and analysis of discursive dynamics in the media can elucidate key aspects of the international struggles encountered. fourth, mncs can be seen as agents of broader issues and changes, which enables us to comprehend how mncs advance neocolonialism or promote positive change in society.”
Velasco, A.. (2020). Populism and Identity Politics. LSE Public Policy Review
“Over one-third of humanity lives under populist regimes-and many of those regimes are turning increasingly authoritarian. it is a worldwide challenge to liberal democracy. the conventional wisdom is that bad economics is to blame: the losers from globalization are angry and voting populists into office is their revenge. the policy implication is a kind of technocratic fantasy: fix the economy and populism will fade away. that view has weak empirical foundations, since many emerging countries that are clear winners from globalization have recently elected populists. in this essay i argue that we cannot understand the surge in populism without understanding the rise of identity politics around the world. identity is the intermediate stopover in the two-way feedback between economics and politics. a focus on identity politics has important practical implications. one of them is that, to succeed in the fight against populism, democratic politicians have to learn to practice identity politics, but of the right kind. the challenge is to build national identities based not on nativism or xenophobia, but on liberal democratic values.”
Wrenn, M.. (2014). Identity, identity politics, and neoliberalism. Panoeconomicus
“With the intensification of neoliberalism, it is useful to examine how some individuals might cope with the irrationality of the system. neoliberalism cloaks the execution of the corporate agenda behind rhetorical manipulation that advocates for limited government. the corollary absence of government involvement on behalf of the citizenry writ large disarms the means of social redress for the individual. democracy funded and fueled by corporate power thereby disenfranchises the individual, provoking some to search for empowerment through identity politics. the argument set forth suggests that individuals construct, reinforce, or escalate allegiance to identities as a coping mechanism, some of which manifest in violent identity politics.”
Chaney, S.. (2020). Am I a researcher or a self-harmer? Mental health, objectivity and identity politics in history. Social Theory and Health
“The different models of self-harm in other eras can challenge the presumed universality of modern concepts, from psychiatric diagnoses to the very idea of objectivity in science and medicine. in this paper i argue that the history of psychiatry is not a neutral set of ideas by which we understand the past but an opportunity to reflect on, critique and improve modern mental healthcare. by writing as omniscient narrators of the past, historians often do create the impression that there is only one interpretation of a set of ideas. incorporating personal material into a narrative is one way of countering this tendency, reminding the reader that the researcher is a part of his or her field of research. yet there are challenges here as well. in identifying as a particular kind of person—a mental health service user—we run the risk of narrowing the field. by exploring the tensions between research and experience, i highlight the importance of critical reflection on identity politics within mental health care and practice today.”
Rafi, M., Purnomo, E. P., & Wicaksono, B.. (2020). Riau Malay Identity Politics. Jurnal Antropologi: Isu-Isu Sosial Budaya
“This article is a study of the process of the rise of riau malay identity politics when it was previously marginalized in the new order era. the purpose of this article is to look at the stages in the formation of identity politics in restoring the glory of malay culture in riau province. this research is descriptive-explorative library research that explains and explores ideas about riau malay identity politics by answering questions in problems identified based on reading results and data interpretation related to the research theme. the results showed that after the reforms, the political elite of the riau province government tried to strengthen malay identity with a variety of policies that were disseminated. then, the negative views that were often directed towards ethnic malay in the past, were rectified again by giving islamic values to all the lives of the malay people. furthermore, the local government and the riau malay customary institution try to re-socialize the importance of the use of malay as the origin of indonesian.”
Knowles, E. D., Tropp, L. R., & Mogami, M.. (2022). When White Americans see “non-Whites” as a group: Belief in minority collusion and support for White identity politics. Group Processes and Intergroup Relations
“White americans may find diversity threatening in part because they construe non-white americans as a coherent social and political force. we argue that this perception manifests in a belief that minority groups collude against white people and that white people should act as a political bloc to defend ingroup interests. in a 3-year longitudinal study, the belief in minority collusion and support for white identity politics increased significantly among a nationally representative sample of 2,635 white americans. compared to white democrats, white republicans more strongly endorsed minority collusion beliefs and white identity politics, and increased more in these beliefs over time. essentialist perceptions of the white ingroup were associated with longitudinal increases in minority collusion beliefs, but not in support for white identity politics. endorsement of minority collusion and support for white identity politics both predicted lower support for black lives matter and greater support for the alt-right movement. implications for race relations, stigma-based solidarity, and the psychology of partisanship and ideology are discussed.”
Fenton, J., & Smith, M.. (2019). ‘You Can’t Say That!’: Critical Thinking, Identity Politics, and the Social Work Academy. Societies
“Recent years have witnessed an eruption of what have been termed culture wars, often converging around the messier aspects of interpersonal relationships and corresponding identity issues that are complex, sensitive, and contested. these are emotive topics that are often colonised by activist groups, and consequently have become enveloped in particular regimes of truth and assertive identity politics. they are often also, by their nature, the kind of issues that are central to social work practice. this can lead to pressure on social workers and social work students to think that these orthodoxies ought to underpin and define the profession, which in turn can lead to the silencing of alternative opinions and the closing down of dissent. this article seeks to locate identity politics in a political and cultural context. it goes on to set out classic arguments for free speech, viewpoint diversity, and for the need for social work to embrace and engage with such. it explores the notion that the closing down of debate about contentious issues, the disincentives that exist to expressing controversial opinions, and the uncritical adoption of ideological orthodoxies work against the development of the critical thinking skills that are essential for social work practice.”
Pérez, M., & Radi, B.. (2020). Gender punitivism: Queer perspectives on identity politics in criminal justice. Criminology and Criminal Justice
“The article examines the convergence of identity politics and punitivism, two tendencies that profoundly affect current lgbt activism and state criminal policies. it considers the case of argentina, a country often deemed exemplary in terms of gender-related legislation, and analyses a 2018 sentence that incorporates the concept of ‘travesticide’ in order to examine how the role of identity in political strategies, added to prevailing notions of gender, limits the possible approaches and answers to violence against gender non-conforming communities. it then takes this a step forward to understand how these answers are, in turn, often reduced to punitivist outcomes, narrowing the understanding of reparation and exposing the most vulnerable subjects in the community to further violence. as a contribution to queer criminologies, the article seeks to expose the limitations of identity politics, and in particular of its advocacy for gendered rights, showing how they can force gender non-conforming subjects to choose between rights, most notably between legal recognition of their gender identity, and safety vis-à-vis the state apparatus of criminal justice.”
Kabir, N. A.. (2020). Identity Politics in India: Gujarat and Delhi Riots. Journal of Muslim Minority Affairs
“Muslims in india have lived alongside hindus peacefully for many centuries. yet in the contemporary period some politicians have orchestrated division for political ends, for example, during the godhra-gujarat riots in india in 2002 in which there were many muslim casualties. critics allege that the ruling party in gujarat, the bharatiya janata party, and its leader chief minister narendra modi (now the prime minister of india) were responsible for the godhra-gujarat riots. once again, in 2020, under narendra modi’s prime ministership, riots against the muslims took place in delhi. within the framework of identity politics in india, where religion seems to dominate the social, economic and political spheres, based on my participants interviews, this paper mainly focuses on how the 2002 gujarat riots impacted on muslims in gujarat. based on other primary sources, this paper also briefly examines the recent 2020 delhi riots. i conclude that, in the era of identity politics when muslims form a disadvantaged minority, national and international policy makers should promulgate policies that would improve social cohesion in india.”
Kaasik-Krogerus, S.. (2020). Identity politics of the promotional videos of the European Heritage Label. Contemporary Politics
“During past decades, the eu has responded to a variety of ‘crises’ by promoting a common cultural heritage to advance european identity and belonging. this article analyses identity politics conducted in the framework of the eu’s flagship heritage action, the european heritage label. i borrow from ‘banal nationalism’ to scrutinise the usage of ‘we’ and ‘us’ in the promotional videos of the european heritage label sites as subject positions offered for identification in this heritage discourse. analysis shows that the subject positions are constituted by an emphasis on the national level, preservation of the past for future generations and the key role of experts in the process of heritage. although the heritage agents talk about europe (representation) they do not identify with that as ‘us’. by making the lack of ‘banal europeanness’ in the videos visible the article shows the ambiguities of european identity politics.”
Lustig, K. C.. (2020). Equal Distribution of Inequality: Totality and the Limits of Identity Politics. Rethinking Marxism
“This essay tracks the limits of identity-based politics, arguing that such political programs fail to adequately theorize their embeddedness within capital and the liberal state. following marx, moishe postone distinguishes between precapitalist societies, in which overt social relations mediate labor, and capitalist societies, in which labor is abstracted and comes to mediate social relations, creating a social totality. following postone, it can be argued that noncapitalist forms of domination, such as racism and patriarchy, are overt forms of domination in which social relations directly mediate labor and its distribution. this claim seemingly strengthens identity politics, but not when considering political programs based on identity lines, which ultimately must adopt and perfect a liberal logic that, rather than eradicating inequality, ensures its more even distribution. this essay shows, for example, how state-driven identity politics based on ethnic difference in israel/palestine fails to account for neoliberal reforms that remake the encounter between jews and arabs.”
Melcher, C. R.. (2021). The political economy of “White Identity Politics”: economic self-interest and perceptions of immigration. Ethnic and Racial Studies
“This article challenges the prevailing contention that economic self-interest does not affect public attitudes toward immigration. through an in-depth re-analysis of the data and findings of ashley jardina’s white identity politics (2019), it is argued, first, that a number of variables that are characterized as status-based or sociotropic can plausibly be interpreted as measuring economic self-interest. second, and more importantly, it is argued that the variables that are often used to measure economic self-interest do not follow from the theoretical claims that are meant to inform their interpretation. third, it is shown that limiting one’s analysis to white respondents–a trend which has become typical, especially since the 2016 us presidential election–severely limits one’s capacity to make convincing explanatory claims. i conclude by arguing that a more appropriate measure of economic self-interest is a measure of perceived job (in)security and a more nuanced measure of employment status.”
Pap, A. L.. (2021). Neglect, Marginalization, and Abuse: Hate Crime Legislation and Practice in the Labyrinth of Identity Politics, Minority Protection, and Penal Populism. Nationalities Papers
“Using hungary as a case study and focusing on legislative policies and the practical application of hate crime legislation, this article shows the various ways legal policy can become misguided in the labyrinth of identity politics, minority protection, and penal populism. the first mistake states can make, the author argues, is not to adopt hate crime legislation. the second error arguably pertains to conceptualizing hate crimes as an identity protection but not a minority-protection mechanism and instrument. the third fallacy the author identifies concerns legislative and practical policies that conceptualize victims based on self-identification and not on the perpetrator’s (or the wider community’s) potential perception and classification. the fourth flaw concerns the abuse of the concept of hate crime when it is applied in interethnic conflicts wherein members of minority communities are perpetrators and the victims are members of the majority communities. the fifth is institutional discrimination through the systematic underpolicing of hate crimes.”
Boyer, M. M., Aaldering, L., & Lecheler, S.. (2022). Motivated Reasoning in Identity Politics: Group Status as a Moderator of Political Motivations. Political Studies
“Western democracies are increasingly defined by identity politics, where politics appeals to both political and other social identities. consequently, political information processing should depend not just on political identity, but also on other identities, such as gender, race, or sexuality. for any given issue, we argue that the extent to which reasoning is motivated by one’s political identity depends on citizens’ group status in other relevant identities, that is, that political identity more strongly motivates high-status group members than low-status group members for issues of identity politics. a survey experiment (n = 1012) concerning a gender quota policy shows that political identity motivates men more strongly than women, leading to political polarization between left-wing and right-wing men, but not women. this suggests that political motivated reasoning should be addressed differently in situations of identity politics, and urges the consideration of group status as a conditional factor of motivated reasoning.”
Dunn, S.. (2021). Identity politics, justice, and the quest for solidarity. Soundings
“This article situates arguments against identity politics within a broader context of philosophical and political arguments about identity and the subject. one pervasive argument is that identity politics is a key factor working against social solidarity in a pluralistic democracy. in order to contest this claim, i use the work of feminist theorists who address a persistent bias against collective identity in western philosophical thought. finally, i argue that the practice of social solidarity requires not jettisoning identity, but re-conceptualizing identity in terms of narrative, which can serve as a basis for understanding one’s moral responsibility to others.”
Lim, E.. (2021). Personal Identity Economics: Facebook and the Distortion of Identity Politics. Social Media and Society
“This article examines facebook’s role in the treatment of marginalized identity as currency. recent examples of solidarity statements and corporate social responsibility rhetoric treat disenfranchised racial and gender identities as value-added competitive market quantities to boost brands. this trend also incentivizes marginalized actors to capitalize on their own disenfranchisement in pursuit of visibility and career advancement. the resulting identity politicking replaces communal care, grassroots social ties, solidarity, and interdependence with isolating market competition. this article diverges from scholars who trouble the differential value of identity—by troubling the valuation of identity itself. facebook normalizes identity as private property in what i call a transition from identity politics to ‘personal identity economics.’ i coin this concept and break it down into the following four factors: (1) the optimization of difference beginning in the 1970s, (2) facebook’s algorithmic invasion of market logic into intimate aspects of life starting in the mid 2000s, (3) ads manager’s economization of identity into legible economic units, and (4) neoliberal corporate social responsibility rhetoric of ‘social good’ as a profitable asset.”
Fukuyama, F.. (2018). Against Identity Politics. Foreign Affairs
Show/hide publication abstract
“Democratic societies are fracturing into segments based on ever-narrower identities, threatening the possibility of deliberation and collective action by society as a whole. unless liberal democracies can work their way back to more universal understandings of human dignity, they will doom themselves—and the world—to continuing conflict.”
Churchwell, S.. (2019). America’s {Original} {Identity} {Politics}. The New York Review of Books
Show/hide publication abstract
“We hear a great deal these days about the right’s hostility to ‘identity politics.’ in this framing, the election of 2016 was a populist backlash of ordinary voters against an aberrant left too concerned with narrow questions about niche groups and out of touch with the troubles of middle americans. the good news is that it simply isn’t true that identity politics represents the end of america or of liberal democracy. nor is it true that identity politics began on the left, or that the klan was america’s first ‘identity movement.’ the only thing new about ‘the omnipresent rhetoric of identity’ is the voices that have been added to it, reshaping it in ways that alarm and affront those who used to be its sole authors. but it was always omnipresent.”
Khedir, H. H.. (2022). Not to mislead peace: on the demise of identity politics in Iraq. Third World Quarterly
“By drawing on theories of transition to democracy, social value shifts and recent studies on iraqi politics and society, this article offers a critical standpoint on the alleged demise/death of identity politics in iraq. the article suggests that the sort of societal transformation that is indispensable to the demise of ‘aggressive sectarianism’, ethnic nationalism and the oppression of minority groups has not yet occurred. any value changes favouring the consolidation of citizenship values and the formation of an iraqi identity require, among other conditions, a stable, sustainable and steady move towards democratisation, good governance and a broader, often lengthy, process of social and economic transformations. the article therefore contends that any attempt at peace in the country necessitates addressing peace as (1) a fundamental matter of governance and (2) an everyday practice in the local terrain. regarding state-building and governance, the article suggests that ‘rectifying’ the post-2003 trend may have adverse consequences should the process run in the direction of retreat from democracy and a rigid re-centralisation of the country. while iraq’s ‘the local’, increasingly vibrant, its constructive impacts on formal politics and peacebuilding, remain uncertain.”
Ilmonen, K.. (2019). Identity politics revisited: On Audre Lorde, intersectionality, and mobilizing writing styles. European Journal of Women’s Studies
“‘Intersectionality’ has taken on a complex position in the field of feminist scholarship over the last decade. debate on the concept has swung back and forth, from buzzword to harsh critique. amid these discussions, many feminist scholars have thought about audre lorde and the role of her writings in the debates over intersectionality. lorde’s radical literary feminism has often been seen both as reflecting a politics of identity, on the one hand, and as shifting and situational, on the other. intersectionality has also been claimed either to be recycling the ideas of identity politics or to be forging new ways to grasp decentered identity positions and power structures. this article aims to tell a story about the roots of intersectionality through – and alongside – the legacy of lorde’s feminism, by revisiting certain identity-political ideas. the radical nature of lorde’s thinking is in many ways connected to politicized writing styles and rebellious literary forms. the main focus in this article is therefore extended to cover the role and implications of radical writing styles for intersectionality. the article argues that the oeuvre of telling the story of intersectionality through lorde’s feminism opens up a new perspective on the genealogy of intersectionality.”
Rudwick, S.. (2018). Language, Africanisation, and Identity Politics at a South African University. Journal of Language, Identity and Education
“After centuries of ‘eurocentric’ linguistic ideology, the south african government has formulated african language development and multilingualism as one priority in the education system. while only english, and decreasingly afrikaans, are the only ‘established’ languages of instruction at tertiary level, most universities in the country have revised their language policies in order to show commitment to south africa’s evident multilingualism. this article provides a critical analysis of particular language and identity politics in one of the leading tertiary institutions of the country. the theoretical framework is based on a critical sociolinguistic approach that draws attention to polarizing identity politics in relation to language policy, planning and implementation. methodologically grounded in ethnography, the article has a two-fold perspective. first, it analyses particular language policy rhetoric at the university on focus and argues that its essentialist approach to africanisation triggers contested identity politics. second, the article provides insights into the developments of specific implementations, pointing to ideological as well as practical challenges at the university on focus.”
Moran, M.. (2018). Identity and identity politics: A cultural-materialist history. Historical Materialism
“This paper draws on the cultural-materialist paradigm articulated by raymond williams to offer a radical historicisation of identity and identity-politics in capitalist societies. a keywords analysis reveals surprisingly that identity, as it is elaborated in the familiar categories of personal and social identity, is a relatively novel concept in western thought, politics and culture. the claim is not the standard one that people’s ‘identities’ became more important and apparent in advanced capitalist societies, but that identity itself came to operate as a new and key mechanism for construing, shaping and narrating experiences of selfhood and grouphood in this period. from a cultural-materialist perspective, the emergence and evolution of this idea of identity can only be properly understood in relation to the social contexts of its use, namely, the new contexts of consumption of capitalist societies, and the development of new forms of group-based struggle from the 1960s. what the analysis shows is that it was the commercialisation and politicisation of older essentialist understandings of selfhood and grouphood in these contexts that has given rise to the concepts of personal and social identity as we know them today. by exploring the material conditions that have given rise to the contemporary powerful attachment to ‘identity’, this paper offers a new point of departure from which to pursue many issues of concern to critical theorists and radical activists today, including the conflict over identity politics in radical circles, the historical and social processes behind their development and at least partial co-option, and their relation to neoliberal political-economic formations today.”
Orjuela, C.. (2014). Corruption and identity politics in divided societies. Third World Quarterly
“Scholars and news media generally name facebook’s two central problems: that its data collection practices are a threat to user privacy, and that stricter regulations are required to prevent ‘bad actor’ from spreading hate and disinformation. however separating these two concerns—personal data collection and bad actors—overlooks the way that one generates the other. first, this article builds on critical race scholarship to examine how identity politics are historically distorted and commodified into profitable vigilance and intolerance, in what i call a transition from identity politics, to personal identity economics. facebook’s ad manager, for example, reveals how personal identities are itemized as advertising assets, which are cultivated through deeper, more trenchant identity politics. second, this article theorizes about what makes such staunch, intolerant identity politics addictive. drawing on max weber’s theories of the protestant ethic, this article explores how facebook activism thrives on deep-rooted christian paradigms of dogma, virtue, redemption, and piety. as dogmatic personal identity economics spread across the globe, they testify to how facebook’s business model manufactures bad actors.”
Prianti, D. D.. (2019). The Identity Politics of Masculinity as a Colonial Legacy. Journal of Intercultural Studies
“Prior to dutch colonization, there was a clear distinction between men and women in indonesia. however, the hierarchical structure between these gender categories is part and parcel of the colonial legacy. masculinity was first introduced in indonesia during the dutch colonial period as a repudiation from femininity. this signaled a significant shift, as previously being modest and part of the community had been valued much more highly in indonesian society than was individuality. by asking to what extent men’s gender expectations are subject to the identity politics of masculinity, and to what extent this is reflected on indonesian popular culture specifically men’s lifestyle magazine, i intend to shed light on the incompatibility of the identity politics of masculinity with contemporary indonesian men. towards this goal, i analyse eight men’s lifestyle magazines, for they play a key role in contemporary modern societies, exposing men to generalized notions of what it means to be a ‘man’. spanning the period from the earliest men’s lifestyle magazines published in indonesia in the mid-1970s until 2015, i map contemporary narratives of masculinity in indonesian context as a reflection of the effects colonial ideologies continue to have on indonesian society and the division of gender roles.”
Kuhn, T.. (2019). Grand theories of European integration revisited: does identity politics shape the course of European integration?. Journal of European Public Policy
“In the early days of european integration, identity politics played a marginal role in what was an isolated, elite-driven, and unpoliticised integration process. things have changed dramatically, however. european integration has entered the area of mass politics, and against the backdrop of the recent crises and the brexit referendum, people’s self-understanding as (also) european or exclusively national has the potential to determine the speed and direction of european integration. this development is also reflected in theory building. while neo-functionalism and liberal intergovernmentalism paid little attention to public opinion, the conflict between collective identities and functionality is at the heart of postfunctionalist theory. this article assesses the use value of these grand theories of european integration for understanding identity politics in the european union, and embeds them in a wider discussion of scholarly research on the causes and consequences of european identity.”
Dotson, K.. (2018). On the way to decolonization in a settler colony: Re-introducing Black feminist identity politics. AlterNative
“In this paper, i explain black feminist identity politics as a practice that is ‘on the way’ to settler decolonization in a us context for the fact that it makes demands that we attend to our ‘originating’ stories and, in doing so, 1) generate potential for difficult coalitions for decolonization in settler colonial usa and 2) promoting a range of refusals (simpson 2014) that aid in resisting the completion of settler colonialism in north america, which is still an uncompleted project. ultimately, i claim black feminist identity politics, properly understood, is a practice that aids in retaining the possibility of decolonization in a settler colonial state by resisting the historical unknowing that facilitates settler futurity. it is not itself settler decolonization, but rather it is ‘on the way’ to such decolonization as it keeps open the need for decolonial futurity.”
Borup, J.. (2020). Who owns religion? Intersectionality, identity politics, and cultural appropriation in postglobal buddhism. Numen
“While historically sharing the characteristics of a universalistic religion and a modernist grand narrative, global buddhism is mainly the product of a late modern development. centripetal forces with circulating ideas, practices, and institutions have been part of a liberal market in an open exchange society with ‘open hermeneutics’ and an accessible universal grammar. its global focus has triggered de-ethnification, de-culturalization, and de-territorialization, claiming transnational universality as a central paradigm fit for a global world beyond isolationalist particularism. however, such seemingly universalist versions of a global buddhism in recent years, mainly in north america, have been criticized for actually being representations of particular cultures (e.g., ‘white buddhism’) with benefits for only particular segments. this article investigates the discourses of this new turn, involving questions of authority, authenticity, identity, cultural appropriation, and representation. it is suggested that criticism of global buddhism should be seen as typical of what could be called ‘postglobal buddhism,’ in which identity politics is a frame of reference serving as a centrifugal force, signaling a new phase in ‘western buddhism.’ the relevance for the study of religion is further discussed with reflections on how to respond to post-global religious identity politics without being consumed by either stark objectivism or subjectivist go-nativism.”
Arrieta Urtizberea, I., Seguí, J., & Roigé, X.. (2020). Folklore, museums and identity politics in Spain: 1931 to present. International Journal of Heritage Studies
“Spain is a country with a vast folklore tradition characterized by deep regional contrasts. the role of folklore museums as a nationalizing tool of the central government and by regional governments (e.g. catalan and basque) to support a diversity of projects for identity construction requires renewed analysis. examined here is the history of the museo del pueblo español (mpe), a national folklore museum created during the second republic (1931–1939) to broadcast the wealth of folkloric tradition within the country. currents of change in national politics during the 20th century have re-oriented the mpe depending on the contrasting perspectives of spanish identity that prevailed at different times in the past. in catalonia and the basque country, where identity claims have been repeatedly asserted since the 19th century, folklore heritage and its representations were seen by nationalist political movements as useful platforms to support a message of ‘difference.’ we propose to use tony bennett’s concepts of the museum as an ‘exhibitionary complex’ and ‘governmental assemblages’ to further clarify the evolution of folklore museums and their role in the development of identity politics in spain.”
Guo, D., & Hu, S.. (2019). Identity Politics and Democratic Crisis in Western Europe. Chinese Political Science Review
“This article analyzes political problems and the democratic crisis in western europe from the perspective of the rise of identity politics. it is argued that the root cause of the crisis lies in the western democracy itself. modern liberal democracy has encouraged the upsurge of active groups based primarily on their distinctive collective identities. with the rise of identity politics, antagonistic groups have struggled for recognition and expanded social divisions among the people, which has led to a representation crisis. both muslim and non-muslim citizens, immigrants and non-immigrant citizens have expressed discontent and dissatisfaction with the democratic governments in almost all western european countries, which has led to a legitimacy crisis. political parties and local governments based on regional or religious identities have mobilized mass support for their independence proposals and posed serious challenges to national unity and solidarity, which has led to a governance crisis. institutional redesign and innovation are important and imperative for overcoming these crises.”
Perry, E., Mandy, W., Hull, L., & Cage, E.. (2022). Understanding Camouflaging as a Response to Autism-Related Stigma: A Social Identity Theory Approach. Journal of Autism and Developmental Disorders
“Camouflaging refers to strategies used by autistic people to mask or hide social difficulties. the current study draws on social identity theory to examine the relationship between camouflaging and autism-related stigma, testing the hypothesis that camouflaging represents an individualistic strategy in response to stigma. two hundred and twenty-three autistic adults completed an online survey measuring perceived autism-related stigma, individualistic and collective strategies, camouflaging and mental wellbeing. results indicated that higher camouflaging was positively associated with autism-related stigma and both individualistic and collective strategy use. autism-related stigma was associated with lower wellbeing however this relationship was not mediated by camouflaging. these findings demonstrate how stigma contributes to camouflaging and highlight the complexities of navigating autistic identity while still camouflaging.”
Mangum, M., & Block, R.. (2018). Social identity theory and public opinion towards immigration. Social Sciences
“Several scholars have called upon social identity theory to investigate the relationship between an american national identity and american public opinion on immigration. lacking a uniform measure of american identity, by and large, scholars find that a two-dimensional conception of american identity influences these opinions. our review suggests that the extant measures of american identity do not fully account for the various aspects of social identity theory. we capture more fully the different components of social identity theory. by doing so, we find that american identity has five dimensions. therefore, in this analysis, we advance a more comprehensive measure of american identity. analyzing data from the 2004-2005 national politics survey, we confirm that all five dimensions of american identity lead to opposition to legal immigration and a preference for spending increases to combat illegal immigration.”
Davis, J. L., Love, T. P., & Fares, P.. (2019). Collective Social Identity: Synthesizing Identity Theory and Social Identity Theory Using Digital Data. Social Psychology Quarterly
“Identity theory (it) and social identity theory (sit) are eminent research programs from sociology and psychology, respectively. we test collective identity as a point of convergence between the two programs. collective identity is a subtheory of sit that pertains to activist identification. collective identity maps closely onto identity theory’s group/social identity, which refers to identification with socially situated identity categories. we propose conceptualizing collective identity as a type of group/social identity, integrating activist collectives into the identity theory model. we test this conceptualization by applying identity theory hypotheses to the ‘vegan’ identity, which is both a social category and part of an active social movement. data come from comments on two viral youtube videos about veganism. one video negates prevailing meanings of the vegan identity. a response video brings shared vegan identity meanings back into focus. identity theory predicts that nonverifying identity feedback elicits negative emotion and active behavioral response, while identity verification elicits positive emotion and an attenuated behavioral response. we test these tenets using sentiment analysis and word counts for comments across the two videos. results show support for identity theory hypotheses as applied to a collective social identity. we supplement results with qualitative analysis of video comments. the findings position collective identity as a bridge between it and sit, demonstrate innovative digital methods, and provide theoretical scaffolding for mobilization research in light of emergent technologies and diverse modes of activist participation.”
Laffan, D. A.. (2021). Positive Psychosocial Outcomes and Fanship in K-Pop Fans: A Social Identity Theory Perspective. Psychological Reports
“Korean pop culture (k-pop) has spread its influence outside of korea to a worldwide fan audience. the present study investigated the self-categorised k-pop fandom characteristics that predicted higher levels of k-pop fanship, and subsequent psychosocial outcomes. social identity theory was applied as a theoretical framework. in total, 1477 k-pop fans from 92 predominantly western countries fully completed an extensive online survey measuring fanship, fandom and psychosocial outcomes (happiness, self-esteem and social connectedness). results of this study indicated that k-pop fanship was significantly predicted by a several k-pop demographic and fandom characteristics. k-pop fanship was a significant predictor of increased happiness, self-esteem and social connectedness. the study findings advance the application of social identity theory in a k-pop fan context and the psychological fanship research more broadly.”
Stets, J. E., & Burke, P. J.. (2000). Identity theory and social identity theory. Social Psychology Quarterly
“In social psychology, we need to establish a general theory of the self, which can attend to both macro and micro processes, and which avoids the redundancies of separate theories on different aspects of the self. for this purpose, we present core components of identity theory and social identity theory and argue that although differences exist between the two theories, they are more differences in emphasis than in kind, and that linking the two theories can establish a more fully integrated view of the self. the core components we examine include the different bases of identity (category/group or role) in each of the theories, identity salience and the activation of identities as discussed in the theories, and the cognitive and motivational processes that emerge from identities based on category/group and on role. by examining the self through the lens of both identity theory and social identity theory, we see how, in combination, they can move us toward a general theory of the self.”
Scheifele, C., Ehrke, F., Viladot, M. A., Van Laar, C., & Steffens, M. C.. (2021). Testing the basic socio-structural assumptions of social identity theory in the gender context: Evidence from correlational studies on women’s leadership. European Journal of Social Psychology
“Given negative social identity, different perceptions of the structure of an intergroup relation (i.e., stability, legitimacy, permeability) should be related to different identity-management strategies (i.e., social competition, social creativity, or individual mobility) depending on group identification. this is among the basic tenets of social identity theory (sit). there is surprisingly little empirical support for these postulates in the context of one of the most central group identities: gender. using a sample of women in leadership positions in spain (n = 649), we tested relations between structural perceptions and identity-management strategies in a pilot study. structural equation modeling yielded empirical support regarding social competition, but little for social creativity or individual mobility. identity-management strategies were related to one organizational outcome (i.e., identification with the organization). the preregistered main study is intended to replicate and extend these findings using a different sample while improving several of the measures used.”
Paruzel, A., Danel, M., & Maier, G. W.. (2020). Scrutinizing Social Identity Theory in Corporate Social Responsibility: An Experimental Investigation. Frontiers in Psychology
“Corporate social responsibility (csr) is widely established by companies that aim to contribute to society and minimize their negative impact on the environment. in csr research, employees’ reactions to csr have extensively been researched. social identity theory is often used as a theoretical background to explain the relationship between csr and employee-related outcomes, but until now, a sound empirical examination is lacking, and causality remains unclear. csr can unfold its effect mainly because of three theoretically important aspects of csr initiatives, which increase identification, i.e., distinctiveness, prestige, and salience of the out-group. this study examines how far identification can explain the effect of csr on employees. in an experimental vignette study (n = 136 employees), csr was manipulated in three degrees (positive, neutral, and negative) to examine its effects on job satisfaction, organizational commitment, and organizational citizenship behavior (ocb). in the vignettes, information on distinctiveness, prestige, and salience of the out-group were presented. regression analyses showed that csr significantly predicted commitment and job satisfaction, but not ocb. we found mediation effects of csr on commitment, job satisfaction, and ocb through identification, but the effect of csr on identification explained only little variance which indicates additional underlying mechanisms. the applicability of social identity theory for explaining csr is discussed. moreover, we discuss further explaining mechanisms.”
Jansen, M. M., & Delahaij, R.. (2020). Leadership Acceptance Through the Lens of Social Identity Theory: A Case Study of Military Leadership in Afghanistan. Armed Forces and Society
“This study builds on the experiences of a dutch reconnaissance platoon deployed in afghanistan in which leadership was not accepted. setup as a qualitative single case study, this article advances our understanding of how group dynamics and contextual factors might impact the acceptance of leadership. rather than primarily focusing on the behavior of the leader, this article highlights the perspective of followers in the ranks. the study also offers empirical evidence for the potential of social identity theory as a framework within which to study leadership acceptance. the case shows that leadership acceptance is largely dependent on group processes rather than on the characteristics of leadership. additionally, it points to the importance of contextual factors. finally, it suggests that a lack of attention to in-group dynamics, and a lack of active entrepreneurship by the leader, can catalyze ‘in-group entrepreneurship.’.”
Willetts, G., & Clarke, D.. (2014). Constructing nurses’ professional identity through social identity theory. International Journal of Nursing Practice
Bochatay, N., Bajwa, N. M., Blondon, K. S., Junod Perron, N., Cullati, S., & Nendaz, M. R.. (2019). Exploring group boundaries and conflicts: a social identity theory perspective. Medical Education
“Context: in the clinical environment, health care professionals self-categorise into different groups towards which they develop positive attitudes, whereas they view other groups less favourably. social identity theory purports that these attitudes influence group processes and may foster conflicts that impede collaborative practice, although this relationship is poorly understood. this study used concepts from social identity theory to examine the interplay between group processes and conflicts, as well as the consequences of these conflicts, with the goal of identifying educational strategies to favour teamwork. methods: semi-structured interviews with 82 randomly selected physicians and nursing professionals working at a swiss academic medical centre explored participants’ experiences of conflicts. data analysis was informed by social identity theory and focused on interviews where group processes were highlighted by participants. the analysis sought to uncover how group processes were intertwined with conflicts and how they affected health care professionals. results: a total of 42 participants out of the initial pool of 82 interviews shared 52 stories of conflicts involving group processes. most of these stories were shared by physicians and involved groups of physicians at different hierarchical levels. conflicts and group processes were linked in two ways: (i) through processes of group membership when individuals struggled to join a relevant group, and (ii) through intergroup boundaries, such as when participants perceived that power differentials disadvantaged their own groups. conflicts could lead to difficult experiences for clinicians who questioned their abilities, became disillusioned with their professional ideals and developed negative perceptions of other groups. conclusions: this study suggests that conflicts involving group processes may lead to stronger intergroup boundaries, challenging current educational efforts to favour teamwork in health care. taking steps to create more inclusive groups and to encourage perspective taking may help manage intergroup conflict.”
Edwards, C., Edwards, A., Stoll, B., Lin, X., & Massey, N.. (2019). Evaluations of an artificial intelligence instructor’s voice: Social Identity Theory in human-robot interactions. Computers in Human Behavior
“This study employs the computers are social actors (casa) paradigm to extend the predictions of social identity theory (sit) to human-robot interaction (hri) in the context of instructional communication. sit posits that individuals gain a sense of personal worth from the groups with which they identify. previous research has demonstrated that age group identification is meaningful to individuals’ self-concepts. results demonstrated that higher age identified students rated the older a.i. voice instructor (representing an out-group member) higher for credibility and social presence and reported more motivation to learn than those students with low age identification. implications are discussed for sit and design features of computerized voices.”
Awuor, D. C.. (2021). Understanding black-african international students’ experiences in united states colleges and universities through social identity theory. Journal of International Students
“In this research in brief, tajfel’s (1970) social identity theory is explained and examined as potentially useful for analyzing the experiences of black-african international students in u. s. colleges and universities. race has been and still is a major issue in the united states. through a review of literature, i sought to find out how black-african international students’ race affected their experiences in the united states.”
Hogg, M. A., Terry, D. J., & White, K. M.. (1995). A Tale of Two Theories: A Critical Comparison of Identity Theory with Social Identity Theory. Social Psychology Quarterly
“Identity theory and social identity theory are two remarkably similar perspectives an the dynamic mediation of the socially constructed self between individual behavior and social structure. yet there is almost no systematic communication between these two perspectivies; they occupy parallel but separate universes. this article describes both theories, summarizes their similarities, critically discusses their differences, and outlines some research directions. against a background of metatheoretical similarity, we find marked differences in terms of 1) level of analysis, 2) the role of intergroup behavior, 3) the relationship between roles and groups, and 4) salience of social context and identity. differences can be traced largely to the microsociological roots of identity theory and the psychological roots of social identity theory. identity theory may be more effective in dealing with chronic identities and with interpersonal social interaction, while social identity theory may be more useful in txploring intergroup dimens1-ons and in specifying the sociocognitive genermive details of identity dynamics.”
Whitaker, M. C.. (2020). Us and Them: Using Social Identity Theory to Explain and Re-envision Teacher–Student Relationships in Urban Schools. Urban Review
“Within a framework of social identity theory (sit), this paper utilizes social cognitive psychological theories to explain how and why white urban teachers often struggle to create loving spaces in urban classrooms, particularly when their students are from social groups different from their own. social categorization theory is useful for describing how the sociocultural context of urban schools and schooling created and sustains the archetypal teacher savior identity. social identity theories of intergroup behavior and organizational role theory are employed to explicate how the group norms of teacher saviors describe and prescribe pedagogical practices that create a hierarchy between teachers and students, leaving little room for warmth and caring. finally, guided by howard’s (we can’t teach what we don’t know: white teachers, multiracial schools, 2nd edn. teachers college press, new york, 2016) concept of a transformationist teacher identity, i offer suggestions for how teacher educators can help preservice teachers cultivate positive teacher–student relationships in their future classrooms by knowing themselves, knowing their students, and knowing their practice. ultimately, sit suggests that urban teachers must be metacognitive about the ways in which their identities are constructed and enacted in schools if they are to care about and for their diverse students.”
Hogg, M. A.. (2001). A social identity theory of leadership. Personality and Social Psychology Review
“A social identity theory of leadership is described that views leadership as a group process generated by social categorization and prototype-based depersonalization processes associated with social identity. group identification, as self-categorization, constructs an intragroup prototypicality gradient that invests the most prototypical member with the appearance of having influence; the appearance arises because members cognitively and behaviorally conform to the prototype. the appearance of influence becomes a reality through depersonalized social attraction processes that make followers agree and comply with the leader’s ideas and suggestions. consensual social attraction also imbues the leader with apparent status and creates a status-based structural differentiation within the group into leader(s) and followers, which has characteristics of unequal status intergroup relations. in addition, a fundamental attribution process constructs a charismatic leadership personality for the leader, which further empowers the leader and sharpens the leader-follower status differential. empirical support for the theory is reviewed and a range of implications discussed, including intergroup dimensions, uncertainty reduction and extremism, power, and pitfalls of prototype-based leadership.”
Ambrose, S. C., Matthews, L. M., & Rutherford, B. N.. (2018). Cross-functional teams and social identity theory: A study of sales and operations planning (S&OP). Journal of Business Research
“Achieving proper levels of integration across functional boundaries is a major challenge for firms. rigorous cross-functional planning processes have arisen within companies in hopes of achieving greater levels of integration. sales and operations planning is one such process designed to help companies better align customer demand with product supply. yet, achieving success with such supply chain processes has continued to elude many firms. this research applies social identity theory to the study of sales and operations planning to see if fostering superordinate identity can help integration efforts in this unique cross-functional team setting. results confirm the importance of superordinate team identity in achieving sales and operations planning performance. furthermore, factors that support superordinate identity formation among teams are identified and discussed.”
Guan, M., & So, J.. (2016). Influence of Social Identity on Self-Efficacy Beliefs Through Perceived Social Support: A Social Identity Theory Perspective. Communication Studies
“While much research documents the influence of self-efficacy on enactment of health behaviors, relatively less attention has been given to the factors that influence self-efficacy. to enhance our understanding of the various sources of self-efficacy, this study integrated social identity theory into this context and proposed and tested a model, which describes a process through which social identity can influence self-efficacy of engaging in health-related behaviors. consistent with the proposed meditational model, the findings showed that individuals who had stronger social identity with a given social group perceived greater social support from the group, which in turn predicted higher self-efficacy of engaging in a health-related behavior advocated by the group, and ultimately predicted greater behavioral intention. theoretical and practical implications are discussed.”
Hornsey, M. J.. (2008). Social Identity Theory and Self-categorization Theory: A Historical Review. Social and Personality Psychology Compass
“The social identity approach (comprising social identity theory and self-categorization theory) is a highly influential theory of group processes and intergroup relations, having redefined how we think about numerous group-mediated phenomena. since its emergence in the early 1970s, the social identity approach has been elaborated, re-interpreted, and occasionally misinterpreted. the goal of this paper is to provide a critical, historical review of how thinking and research within the social identity approach has evolved. the core principles of the theories are reviewed and discussed, and their effect on the field assessed. strengths and limitations of the approach are discussed, with an eye to future developments.”
Ferguson, M. A., & Ford, T. E.. (2008). Disparagement humor: A theoretical and empirical review of psychoanalytic, superiority, and social identity theories. Humor
“Interest in the concept of identity has grown exponentially within both the humanities and social sciences, but the discussion of identity has had less impact than might be expected on the quantitative study of political behavior in general and on political psychology more specifically. one of the approaches that holds the most promise for political psychologists is social identity theory, as reflected in the thinking of henri tajfel, john turner, and colleagues. although the theory addresses the kinds of problems of interest to political psychologists, it has had limited impact on political psychology because of social identity theorists’ disinclination to examine the sources of social identity in a real world complicated by history and culture. in this review, four key issues are examined that hinder the successful application of social identity theory to political phenomena. these key issues are the existence of identity choice, the subjective meaning of identities, gradations in identity strength, and the considerable stability of many social and political identities.”
Pan, N. D., Gruber, M., & Binder, J.. (2019). Painting with All the Colors: The Value of Social Identity Theory for Understanding Social Entrepreneurship. Academy of Management Review
“Building on the emerging body of research on founder identity, wry and york (2017) elaborate how an identity-based approach has the potential to extend our knowledge of opportunity identification in social entrepreneurship. in particular, the authors draw on role identity theory (stryker & burke, 2000) and research on personal identity (hitlin, 2003) to study hybrid identities within single individuals. while role and personal identity are useful constructs for studying entrepreneurial behavior, we are concerned about the foregone opportunity to use social identity theory for advancing our knowledge of social entrepreneurs as enterprising individuals, social venture creation processes, and related outcomes. indeed, in this commentary, we argue that social identity theory holds more potential – than either role or personal identity theory – for analyzing the rich ‘other-oriented’ behavior that is at the heart of social entrepreneurship.”
Seering, J., Ng, F., Yao, Z., & Kaufman, G.. (2018). Applications of social identity theory to research and design in social computing. Proceedings of the ACM on Human-Computer Interaction
“Research in computer-supported cooperative work has historically focused on behaviors of individuals at scale, using frames of interpersonal interaction such as goffman’s theories of self-presentation. these frames prioritize research detailing the characteristics, personal identities, and behaviors of large numbers of interacting individuals, while the social identity concepts that lead to intra- and inter-group dynamics have received far less attention. we argue that the emergent properties of self-categorization and social identity, which are particularly fluid and complex in online spaces, provide a complementary perspective with which to re-examine traditional topics in social computing. we discuss the applicability of the social identity perspective to both established and new research domains in cscw, proposing alternative perspectives on self-presentation, social support, collaboration, misbehavior, and leadership. we propose a set of methodological considerations derived from this body of theories and accompanying empirical work. we close by considering how broad concepts and lessons from social identity provide a valuable lens for inspiring future work in cscw.”
Raskovic, M., & Takacs-Haynes, K.. (2020). (Re)discovering social identity theory: an agenda for multinational enterprise internalization theory. Multinational Business Review
“Purpose: firm internalization is a central concept within the business strategy literature, as part of the broader social sciences. the purpose of this paper is to show how and where mne internalization theory can benefit from a social identity theory (sit) perspective to better understand 21st-century multinational enterprises (mnes). design/methodology/approach: this paper provides a review and future research agenda for the use of sit related to mne internalization theory. the authors complement an evolutionary review of sit literature with a systematic bibliometric analysis identifying specific thematic gaps. extending buckley and casson’s review of and future research agenda for mne internalization theory, the authors propose three specific future research directions along with eight guiding research questions. findings: international business (ib) scholars are familiar with limited aspects of sit and apply it only in certain research areas, mainly connected to human resource management and leadership, organizational identity and work-related outcomes or international marketing. strategic management and strategy-oriented ib scholars are less familiar with sit, despite growing interest in mne micro-foundations and decision-making under uncertainty. originality/value: the authors position sit as a natural meta-theoretical fit to mne internalization theory. by providing a future research agenda along with eight supporting research questions, the authors help to advance the mne internalization theory by linking individual, group and intergroup perspectives against a more socially nuanced, interactionist and dynamic view of mnes and their decision-making.”
Lam, S. K., Ahearne, M., Hu, Y., & Schillewaert, N.. (2010). Resistance to brand switching when a radically new brand is introduced: A social identity theory perspective. Journal of Marketing
Consumer Behavior and Advertising Involvement: Selected Works of Herbert E. Krugman (Marketing and Consumer Psychology Series)
This book is an honor to the many important contributions of Herbert Krugman, past president of APA (American Psychological Association), The Division of Consumer Psychology and The Association for Public Opinions Research. This reader contains his selected works in Consumer Behavior and Advertising which combine insights from Cognitive Psychology, Social Psychology and Survey Methodology. William Wells, University of Minnesota, has provided the foreword and section overviews for the book which will help it appeal to all academics and students of consumer research.
“The fact that TV is a source not actively or critically attended to was made dramatically evident in the late 1960s by an experiment that rocked the world of political and product advertising and forever changed the ways in which the television medium would be used. The results of the experiment still reverberate through the industry long after its somewhat primitive methods have been perfected.
“In November 1969, a researcher named Herbert Krugman, who later became manager of public-opinion research at General Electric headquarters in Connecticut, decided to try to discover what goes on physiologically in the brain of a person watching TV. He elicited the co-operation of a twenty-two-year-old secretary and taped a single electrode to the back of her head. The wire from this electrode connected to a Grass Model 7 Polygraph, which in turn interfaced with a Honeywell 7600 computer and a CAT 400B computer.
“Flicking on the TV, Krugman began monitoring the brain-waves of the subject What he found through repeated trials was that within about thirty seconds, the brain-waves switched from predominantly beta waves, indicating alert and conscious attention, to predominantly alpha waves, indicating an unfocused, receptive lack of attention: the state of aimless fantasy and daydreaming below the threshold of consciousness. When Krugman’s subject turned to reading through a magazine, beta waves reappeared, indicating that conscious and alert attentiveness had replaced the daydreaming state.
“What surprised Krugman, who had set out to test some McLuhanesque hypotheses about the nature of TV-viewing, was how rapidly the alpha-state emerged. Further research revealed that the brain’s left hemisphere, which processes information logically and analytically, tunes out while the person is watching TV. This tuning-out allows the right hemisphere of the brain, which processes information emotionally and noncritically, to function unimpeded. ‘It appears,’ wrote Krugman in a report of his findings, ‘that the mode of response to television is more or less constant and very different from the response to print. That is, the basic electrical response of the brain is clearly to the medium and not to content difference…. [Television is] a communication medium that effortlessly transmits huge quantities of information not thought about at the time of exposure.’
“Soon, dozens of agencies were engaged in their own research into the television-brain phenomenon and its implications. The findings led to a complete overhaul in the theories, techniques, and practices that had structured the advertising industry and, to an extent, the entire television industry. The key phrase in Krugman’s findings was that TV transmits ‘information not thought about at the time of exposure.'” [p.p. 69-70]
“As Herbert Krugman noted in the research that transformed the industry, we do not consciously or rationally attend to the material resonating with our unconscious depths at the time of transmission. Later, however, when we encounter a store display, or a real-life situation like one in an ad, or a name on a ballot that conjures up our television experience of the candidate, a wealth of associations is triggered. Schwartz explains: ‘The function of a display in the store is to recall the consumer’s experience of the product in the commercial…. You don’t ask for a product: The product asks for you! That is, a person’s recall of a commercial is evoked by the product itself, visible on a shelf or island display, interacting with the stored data in his brain.’ Just as in Julian Jaynes’s ancient cultures, where the internally heard speech of the gods was prompted by props like the corpse of a chieftain or a statue, so, too, our internalized media echoes are triggered by products, props, or situations in the environment.
“As real-life experience is increasingly replaced by the mediated ‘experience’ of television-viewing, it becomes easy for politicians and market-researchers of all sorts to rely on a base of mediated mass experience that can be evoked by appropriate triggers. The TV ‘world’ becomes a self-fulfilling prophecy: the mass mind takes shape, its participants acting according to media-derived impulses and believing them to be their own personal volition arising out of their own desires and needs. In such a situation, whoever controls the screen controls the future, the past, and the present.” [p. 82, Joyce Nelson, THE PERFICT MACHINE; New Society Pub., 1992, 800-253-3605; ISBN 0-86571-235-2
Source: www.modeemi.fi/~no/page24.html
Further References
Krugman, H. E.. (1977). Public Attitudes toward the Apollo Space Program, 1965–1975. Journal of Communication, 27(4), 87–93.
“A new device that measures changes in pupil diameter while subjects view advertisements, packages, etc., offers promise of becoming a powerful tool for studying the interest-arousing qualities of stimuli. encouraging evidence of the reliability and validity of this device has been found in a series of studies —two of which are described in this article.”
Krugman, H. E.. (1966). White and Negro Responses to Package Designs. Journal of Marketing Research, 3(2), 199.
Krugman, H. E.. (1983). Television program interest and commercial interruption. Journal of Advertising Research
Show/hide publication abstract
“Examines the correlation between effectiveness of an interrupting commercial and the popularity level of the subsequent television (tv) program. need to distinguish between viewer opinion and impact of commercial on viewers; analysis of type of tv shows and their impact value.”
Krugman, H. E.. (1965). The Impact of Television Advertising: Learning Without Involvement. Public Opinion Quarterly, 29(3), 349.
DDT (dichloro-diphenyl-trichloroethane) was developed as the first of the modern synthetic insecticides in the 1940s. It was initially used with great effect to combat malaria, typhus, and the other insect-borne human diseases among both military and civilian populations (including “mass-spraying” on children – see video below). Toxicological studies demonstrate that DDT has numerous adverse effects (see references below).
Hawkey, A. B., Holloway, Z., Dean, C., Koburov, R., Slotkin, T. A., Seidler, F. J., & Levin, E. D.. (2021). Neurobehavioral anomalies in zebrafish after sequential exposures to DDT and chlorpyrifos in adulthood: Do multiple exposures interact?. Neurotoxicology and Teratology, 87, 106985.
“A sequence of different classes of synthetic insecticides have been used over the past 70 years. over this period, the widely-used organochlorines were eventually replaced by organophosphates, with dichlorodiphenyltrichloroethane (ddt) and chlorpyrifos (cpf) as the principal prototypes. considerable research has characterized the risks of ddt and cpf individually, but little is known about the toxicology of transitioning from one class of insecticides to another, as has been commonplace for agricultural and pest control workers. this study used adult zebrafish to investigate neurobehavioral toxicity following 5-week chronic exposure to either ddt or cpf, to or their sequential exposure (ddt for 5 weeks followed by cpf for 5 weeks). at the end of the exposure period, a subset of fish were analyzed for brain cholinesterase activity. behavioral effects were initially assessed one week following the end of the cpf exposure and again at 14 months of age using a behavioral test battery covering sensorimotor responses, anxiety-like functions, predator avoidance and social attraction. adult insecticide exposures, individually or sequentially, were found to modulate multiple behavioral features, including startle responsivity, social approach, predator avoidance, locomotor activity and novel location recognition and avoidance. locomotor activity and startle responsivity were each impacted to a greater degree by the sequential exposures than by individual compounds, with the latter being pronounced at the early (1-week post exposure) time point, but not 3–4 months later in aging. social approach responses were similarly impaired by the sequential exposure as by cpf-alone at the aging time point. fleeing responses in the predator test showed flee-enhancing effects of both compounds individually versus controls, and no additive impact of the two following sequential exposure. each compound was also associated with changes in recognition or avoidance patterns in a novel place recognition task in late adulthood, but sequential exposures did not enhance these phenotypes. the potential for chemical x chemical interactions did not appear related to changes in cpf metabolism to the active oxon, as prior ddt exposure did not affect the cholinesterase inhibition resulting from cpf. this study shows that the effects of chronic adult insecticide exposures may be relevant to behavioral health initially and much later in life, and that the effects of sequential exposures may b…”
Krzastek, S. C., Farhi, J., Gray, M., & Smith, R. P.. (2020). Impact of environmental toxin exposure on male fertility potential. Translational Andrology and Urology, 9(6), 2797–2813.
“Idiopathic infertility is the most common individual diagnosis in male infertility, representing nearly 44% of cases. research studies dating over the last half-century consistently demonstrate a decline in male fertility that is incompletely explained by obesity, known genetic causes, or diet and lifestyle changes alone. human exposures have changed dramatically over the same time course as this fertility decline. synthetic chemicals surround us. some are benevolent; however, many are known to cause disruption of the hypothalamic-pituitary-gonadal axis and impair spermatogenesis. more than 80,000 chemicals are registered with the united states national toxicology program and nearly 2,000 new chemicals are introduced each year. many of these are known toxins, such as phthalates, polycyclic aromatic hydrocarbons, aromatic amines, and organophosphate esters, and have been banned or significantly restricted by other countries as they carry known carcinogenic effects and are reproductively toxic. in the united states, many of these chemicals are still permissible in exposure levels known to cause reproductive harm. this contrasts to other chemical regulatory legislature, such as the european union’s reach (registration, evaluation, authorization and restriction of chemicals) regulations which are more comprehensive and restrictive. quantification of these diverse exposures on an individual level has proven challenging, although forthcoming technologies may soon make this data available to consumers. establishing causality and the proportion of idiopathic infertility attributable to environmental toxin exposures remains elusive, however, continued investigation, avoidance of exposure, and mitigation of risk is essential to our reproductive health. the aim of this review is to examine the literature linking changes in male fertility to some of the most common environmental exposures. specifically, pesticides and herbicides such as dichlorodiphenyltrichloroethane (ddt), dibromochloropropane (dbcp), organophosphates and atrazine, endocrine disrupting compounds including plastic compounds phthalates and bisphenol a (bpa), heavy metals, natural gas/oil, non-ionizing radiation, air and noise pollution, lifestyle factors including diet, obesity, caffeine use, smoking, alcohol and drug use, as well as commonly prescribed medications will be discussed.”
Russell, P. F.. (1972). DDT Toxicology. Science, 177(4047), 387–388.
Persson, E. C., Graubard, B. I., Evans, A. A., London, W. T., Weber, J.-P., LeBlanc, A., … McGlynn, K. A.. (2012). Dichlorodiphenyltrichloroethane and risk of hepatocellular carcinoma. International Journal of Cancer, 131(9), 2078–2084.
Oliver, S. V., & Brooke, B. D.. (2013). The effect of larval nutritional deprivation on the life history and DDT resistance phenotype in laboratory strains of the malaria vector Anopheles arabiensis. Malaria Journal, 12(1), 44.
“Due to uncontrolled use for several decades, dichlorodiphenyltrichloroethane (ddt), probably the best known and most useful insecticide in the world, has damaged wildlife and might have negative effects on human health. this review gives a brief history of the use of ddt in various countries and presents the results of epidemiologic and experimental studies of carcinogenesis. even though its use has been prohibited in most countries for ecologic considerations, mainly because of its negative impact on wildlife, it is still used in some developing countries for essential public health purposes, and it is still produced for export in at least three countries. due to its stability and its capacity to accumulate in adipose tissue, it is found in human tissues, and there is now not a single living organism on the planet that does not contain ddt. the possible contribution of ddt to increasing the risks for cancers at various sites and its possible role as an endocrine disruptor deserve further investigation. although there is convincing experimental evidence for the carcinogenicity of ddt and of its main metabolites dde and ddd, epidemiologic studies have provided contrasting or inconclusive, although prevailingly negative, results. the presence and persistence of ddt and its metabolites worldwide are still problems of great relevance to public health. efficient pesticides that do not have the negative properties of ddt, together with the development of alternative methods to fight malaria, should be sought with the goal of completely banning ddt.”
Booij, P., Holoubek, I., Klánová, J., Kohoutek, J., Dvorská, A., Magulová, K., … Čupr, P.. (2016). Current implications of past DDT indoor spraying in Oman. Science of The Total Environment, 550, 231–240.
“In oman, ddt was sprayed indoors during an intensive malaria eradication program between 1976 and 1992. ddt can remain for years after spraying and is associated with potential health risk. this raises the concern for human exposure in areas where ddt was used for indoor spraying. twelve houses in three regions with a different history of ddt indoor spraying were chosen for a sampling campaign in 2005 to determine p,p’-dichlorodiphenyltrichloroethane (p,p’-ddt), p,p’-dichlorodiphenyldichloroethylene (p,p’-dde) and p,p’-dichlorodiphenyldichloroethane (p,p’-ddd) levels in indoor air, dust, and outdoor soil. although ddt was only sprayed indoor, p,p’-ddt, p,p’-dde and p,p’-ddd were also found in outdoor soil. the results indicate that release and exposure continue for years after cessation of spraying. the predicted cancer risk based on concentrations determined in 2005, indicate that there was still a significant cancer risk up to 13 to 16 years after indoor ddt spraying. a novel approach, based on region-specific half-lives, was used to predict concentrations in 2015 and showed that more than 21. years after spraying, cancer risk for exposure to indoor air, dust, and outdoor soil are acceptable in oman for adults and young children. the model can be used for other locations and countries to predict prospective exposure of contaminants based on indoor experimental measurements and knowledge about the spraying time-schedule to extrapolate region-specific half-lives and predict effects on the human population years after spraying.”
Rosner, D., & Markowitz, G.. (2013). Persistent pollutants: A brief history of the discovery of the widespread toxicity of chlorinated hydrocarbons. Environmental Research, 120, 126–133.
Abstract:
The experiments here described were performed on an island in Boston Harbor, on volunteers obtained from the Navy. The work was conducted by a group of officers detailed for that purpose, from the U. S. Navy and the U. S. Public Health Service, consisting of Dr. G. W. McCoy, director of the Hygienic Library, Dr. Joseph Goldberger, Dr. Leake, and Dr. Lake, all on the part of the U. S. Public Health Service; and cooperating with those medical officers, was a group also detailed for this purpose on the part of the U. S. Navy, consisting of Dr. J. J. Keegan, Dr. De Wayne Richey and myself.
The work itself was conducted at Gallops Island, which is the quarantine station of the Port of Boston, and peculiarly well fitted for operations of this kind, serving adequately for the purposes of isolation, observations, and maintenance of the large group of volunteers
—
Excerpt:
“The volunteers were all of the most susceptible age, mostly between 18 and 25, only a few of them around 30 years old ; and all were in good physical condition. None of these volunteers, 100 all told in number, had “influenza ;” that is, from the most care¬ ful histories that we could elicit, they gave no account of a febrile attack of any kind during the winter, except a few who were purposely selected, as having shown a typical attack of influenza, in order to test questions of immunity, and for the purpose of control. Now, we proceeded rather cautiously at first by administering a pure culture of bacillus of influenza, Pfeiffer’s bacillus, in a rather moderate amount, into the nostrils of a few of these volunteers. These early experiments I will not stop to relate, but I will go at once to what I may call our Experiment 1.”
***
As the preliminary trials proved negative, we became bolder, and selecting nineteen of our volunteers, gave each one of them a very large quantity of a mixture of thirteen different strains of the Pfeiffer bacillus, some of them obtained recently from the lungs at necropsy; others were subcultures of varying age, and each of the thirteen had, of course, a different history. Suspensions of these organisms were sprayed with an atomi¬ zer into the nose and into the eyes, and back into the throat, while the volunteers were breathing in. We used some billions of these organisms, according to our estimated counts, on each one of the volunteers, but none of them took sick. Then we proceeded to transfer the virus obtained from cases of the disease ; that is, we collected the material and mucous secretions of the mouth and nose and throat and bronchi from cases of the disease and transferred this to our volunteers. We always obtained this material in the same way : The patient with fever, in bed, has a large, shallow, traylike arrangement before him or her, and we washed out one nostril with some sterile salt solution, using perhaps 5 ce., which is allowed to run into this tray ; and that nostril is blown vigorously into the tray. This is repeated with the other nostril. The patient then gargles with some of the solution. Next we obtain some bronchial mucus through coughing, and then we swab the mucous surface of each nares and also the mucous membrane of the throat. We place these swabs with the material in a bottle with glass beads, and add all the material obtained in the tray. This is the stuff we transfer to our volunteers. In this par¬ ticular experiment, in which we used ten volunteers, each of them received a comparatively small quantity of this, about 1 c.c. sprayed into each nostril and into the throat, while inspiring, and on the eye. None of these took sick. Some of the same material was fil¬ tered and instilled into other volunteers but produced no results.
***
Our next experiment consisted in injections of blood. We took five donors, five cases of influenza in the febrile stage, some of them again quite early in the disease. We drew 20 ‘c.c. from the arm vein of each, making a total of 100 c.c, which was mixed and treated with 1 per cent, of sodium citrate. Ten c.c. of the citrated whole blood were injected into each of the ten volunteers. None of them took sick in any way. Then we collected a lot of mucous material from the upper respiratory tract, and filtered ‘ it through Man- dler filters. While these filters will hold back the bacteria of ordinary size, they will allow “ultramicro- scopic” organisms to pass. This filtrate was injected into ten volunteers, each one receiving 3.5 c.c. sub- cutaneously, and none of these took sick in any way.
“Perhaps the most interesting epidemiological studies conducted during the 1918–1919 pandemic were the human experiments conducted by the Public Health Service and the U.S. Navy under the supervision of Milton Rosenau on Gallops Island, the quarantine station in Boston Harbor, and on Angel Island, its counterpart in San Francisco. The experiment began with 100 volunteers from the Navy who had no history of influenza. Rosenau was the first to report on the experiments conducted at Gallops Island in November and December 1918.69 His first volunteers received first one strain and then several strains of Pfeiffer’s bacillus by spray and swab into their noses and throats and then into their eyes. When that procedure failed to produce disease, others were inoculated with mixtures of other organisms isolated from the throats and noses of influenza patients. Next, some volunteers received injections of blood from influenza patients. Finally, 13 of the volunteers were taken into an influenza ward and exposed to 10 influenza patients each. Each volunteer was to shake hands with each patient, to talk with him at close range, and to permit him to cough directly into his face. None of the volunteers in these experiments developed influenza. Rosenau was clearly puzzled, and he cautioned against drawing conclusions from negative results. He ended his article in JAMA with a telling acknowledgement: “We entered the outbreak with a notion that we knew the cause of the disease, and were quite sure we knew how it was transmitted from person to person. Perhaps, if we have learned anything, it is that we are not quite sure what we know about the disease.”69 (p. 313)
The research conducted at Angel Island and that continued in early 1919 in Boston broadened this research by inoculating with the Mathers streptococcus and by including a search for filter-passing agents, but it produced similar negative results.70–72 It seemed that what was acknowledged to be one of the most contagious of communicable diseases could not be transferred under experimental conditions.” www.ncbi.nlm.nih.gov/pmc/articles/PMC2862332/