Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI) or psychoneuroendocrinoimmunology (PNEI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. It is a subfield of psychosomatic medicine. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.

The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.

It is now clear that the cellular and molecular processes that make up our ‘immune system’ are also crucial to normal brain development and play a role in the pathoaetiology of many mental and physical disorders.


Troyer, E. A., Kohn, J. N., & Hong, S.. (2020). Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain, Behavior, and Immunity, 87, 34–39.

Plain numerical DOI: 10.1016/j.bbi.2020.04.027
DOI URL
directSciHub download

Hamilton-West, K.. (2011). Psychobiological Processes in Health and Illness. Psychobiological Processes in Health and Illness. 1 Oliver’s Yard, 55 City Road, London EC1Y 1SP United Kingdom: SAGE Publications Ltd

Plain numerical DOI: 10.4135/9781446251324
DOI URL
directSciHub download

Mravec, B., Tibensky, M., & Horvathova, L.. (2020). Stress and cancer. Part II: Therapeutic implications for oncology. Journal of Neuroimmunology, 346, 577312.

Plain numerical DOI: 10.1016/j.jneuroim.2020.577312
DOI URL
directSciHub download

Pahlevi, R., Putra, S. T., & Sriyono, S.. (2017). Psychoneuroimmunology Approach to Improve Recovery Motivation, Decrease Cortisol and Blood Glucose of DM Type 2 Patients with Dhikr Therapy. Jurnal Ners, 12(1), 60–65.

Plain numerical DOI: 10.20473/jn.v12i1.2315
DOI URL
directSciHub download

Mathews, H. L., & Janusek, L. W.. (2011). Epigenetics and psychoneuroimmunology: Mechanisms and models. Brain, Behavior, and Immunity, 25(1), 25–39.

Plain numerical DOI: 10.1016/j.bbi.2010.08.009
DOI URL
directSciHub download

Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S.. (2020). Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge. Psychoneuroendocrinology, 111, 104501.

Plain numerical DOI: 10.1016/j.psyneuen.2019.104501
DOI URL
directSciHub download

Leckman, J. F.. (2014). Commentary: What does immunology have to do with brain development and psychopathology? – A commentary on O’Connor et al. (2014). Journal of Child Psychology and Psychiatry and Allied Disciplines

Plain numerical DOI: 10.1111/jcpp.12259
DOI URL
directSciHub download

Segerstrom, S. C., Glover, D. A., Craske, M. G., & Fahey, J. L.. (1999). Worry Affects the Immune Response to Phobic Fear. Brain, Behavior, and Immunity, 13(2), 80–92.

Plain numerical DOI: 10.1006/brbi.1998.0544
DOI URL
directSciHub download

Aziez Chettoum, Kamilia Guedri, Zouhir Djerrou, Rachid Mosbah, Latifa Khattabi, Abir Boumaaza, & Wissam Benferdi. (2020). Distribution of leukocyte subpopulation among students threatened by failure. International Journal of Research in Pharmaceutical Sciences, 11(3), 3807–3812.

Plain numerical DOI: 10.26452/ijrps.v11i3.2553
DOI URL
directSciHub download