In this review we provide an analysis of recent literature reports on the synthesis and applications of stimuli-responsive polymeric and hybrid nanostructured particles in a range of sizes from nanometers to a few micrometers: nano- and microgels, core–shell structures, polymerosomes, block-copolymer micelles, and more complex architectures. The review consists of two major parts: synthesis and applications of nanoparticles in colloidal dispersions, thin films, delivery devices and sensors. We also broadly discuss potential directions for further developments of this research area.
Motornov, M., Roiter, Y., Tokarev, I., & Minko, S.. (2010). Stimuli-responsive nanoparticles, nanogels and capsules for integrated multifunctional intelligent systems. Progress in Polymer Science, 35(1–2), 174–211.
Buwalda, S. J., Boere, K. W. M., Dijkstra, P. J., Feijen, J., Vermonden, T., & Hennink, W. E.. (2014). Hydrogels in a historical perspective: From simple networks to smart materials. Journal of Controlled Release, 190, 254–273.
“Over the past decades, significant progress has been made in the field of hydrogels as functional biomaterials. biomedical application of hydrogels was initially hindered by the toxicity of crosslinking agents and limitations of hydrogel formation under physiological conditions. emerging knowledge in polymer chemistry and increased understanding of biological processes resulted in the design of versatile materials and minimally invasive therapies. hydrogel matrices comprise a wide range of natural and synthetic polymers held together by a variety of physical or chemical crosslinks. with their capacity to embed pharmaceutical agents in their hydrophilic crosslinked network, hydrogels form promising materials for controlled drug release and tissue engineering. despite all their beneficial properties, there are still several challenges to overcome for clinical translation. in this review, we provide a historical overview of the developments in hydrogel research from simple networks to smart materials.”