Psychoneuroimmunology

Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI) or psychoneuroendocrinoimmunology (PNEI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. It is a subfield of psychosomatic medicine. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.

The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.

It is now clear that the cellular and molecular processes that make up our ‘immune system’ are also crucial to normal brain development and play a role in the pathoaetiology of many mental and physical disorders.


Troyer, E. A., Kohn, J. N., & Hong, S.. (2020). Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms. Brain, Behavior, and Immunity, 87, 34–39.

Plain numerical DOI: 10.1016/j.bbi.2020.04.027
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Hamilton-West, K.. (2011). Psychobiological Processes in Health and Illness. Psychobiological Processes in Health and Illness. 1 Oliver’s Yard, 55 City Road, London EC1Y 1SP United Kingdom: SAGE Publications Ltd

Plain numerical DOI: 10.4135/9781446251324
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Mravec, B., Tibensky, M., & Horvathova, L.. (2020). Stress and cancer. Part II: Therapeutic implications for oncology. Journal of Neuroimmunology, 346, 577312.

Plain numerical DOI: 10.1016/j.jneuroim.2020.577312
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Pahlevi, R., Putra, S. T., & Sriyono, S.. (2017). Psychoneuroimmunology Approach to Improve Recovery Motivation, Decrease Cortisol and Blood Glucose of DM Type 2 Patients with Dhikr Therapy. Jurnal Ners, 12(1), 60–65.

Plain numerical DOI: 10.20473/jn.v12i1.2315
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Mathews, H. L., & Janusek, L. W.. (2011). Epigenetics and psychoneuroimmunology: Mechanisms and models. Brain, Behavior, and Immunity, 25(1), 25–39.

Plain numerical DOI: 10.1016/j.bbi.2010.08.009
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Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S.. (2020). Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge. Psychoneuroendocrinology, 111, 104501.

Plain numerical DOI: 10.1016/j.psyneuen.2019.104501
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Leckman, J. F.. (2014). Commentary: What does immunology have to do with brain development and psychopathology? – A commentary on O’Connor et al. (2014). Journal of Child Psychology and Psychiatry and Allied Disciplines

Plain numerical DOI: 10.1111/jcpp.12259
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Segerstrom, S. C., Glover, D. A., Craske, M. G., & Fahey, J. L.. (1999). Worry Affects the Immune Response to Phobic Fear. Brain, Behavior, and Immunity, 13(2), 80–92.

Plain numerical DOI: 10.1006/brbi.1998.0544
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Aziez Chettoum, Kamilia Guedri, Zouhir Djerrou, Rachid Mosbah, Latifa Khattabi, Abir Boumaaza, & Wissam Benferdi. (2020). Distribution of leukocyte subpopulation among students threatened by failure. International Journal of Research in Pharmaceutical Sciences, 11(3), 3807–3812.

Plain numerical DOI: 10.26452/ijrps.v11i3.2553
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Effects of trauma on personality and genetics



Further References

Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2019). A Meta-analysis of Intervention Effects on Depression and/or Anxiety in Youth Exposed to Political Violence or Natural Disasters. Child and Youth Care Forum

Plain numerical DOI: 10.1007/s10566-019-09494-9
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Pfefferbaum, B., Noffsinger, M. A., & Wind, L. H.. (2012). Issues in the assessment of Children’s coping in the context of mass trauma. Prehospital and Disaster Medicine

Plain numerical DOI: 10.1017/S1049023X12000702
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Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2021). A critical review of effective child mass trauma interventions: What we know and do not know from the evidence. Behavioral Sciences

Plain numerical DOI: 10.3390/bs11020025
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Pfefferbaum, B., Nitiéma, P., & Newman, E.. (2020). The Effect of Interventions on Functional Impairment in Youth Exposed to Mass Trauma: a Meta-Analysis. Journal of Child and Adolescent Trauma

Plain numerical DOI: 10.1007/s40653-019-00266-0
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Pfefferbaum, B., Nitiéma, P., Newman, E., & Patel, A.. (2019). The Benefit of Interventions to Reduce Posttraumatic Stress in Youth Exposed to Mass Trauma: A Review and Meta-Analysis. Prehospital and Disaster Medicine

Plain numerical DOI: 10.1017/S1049023X19004771
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Tarvydas, V. M., Levers, L. L., & Teahen, P. R.. (2017). Ethical Guidelines for Mass Trauma and Complex Humanitarian Emergencies. Journal of Counseling and Development

Plain numerical DOI: 10.1002/jcad.12140
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Pfefferbaum, B., Tucker, P., Nitiéma, P., Van Horn, R. L., Varma, V., Varma, Y., … Newman, E.. (2022). Inconclusive Findings in Studies of the Link Between Media Coverage of Mass Trauma and Depression in Children. Current Psychiatry Reports

Plain numerical DOI: 10.1007/s11920-022-01328-1
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Meffert, S., & Ekblad, S.. (2013). Global mental health intervention research and mass trauma. Open Access Journal of Clinical Trials

Plain numerical DOI: 10.2147/OAJCT.S37037
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Hobfoll, S. E., Watson, P., Bell, C. C., Bryant, R. A., Brymer, M. J., Friedman, M. J., … Ursano, R. J.. (2007). Five essential elements of immediate and mid-term mass trauma intervention: Empirical evidence. Psychiatry

Plain numerical DOI: 10.1521/psyc.2007.70.4.283
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Husain, M. I., Umer, M., Chaudhry, I. B., Husain, M. O., Rahman, R., Shakoor, S., … Husain, N.. (2021). Relationship between childhood trauma, personality, social support and depression in women attending general medical clinics in a low and middle-income country. Journal of Affective Disorders

Plain numerical DOI: 10.1016/j.jad.2021.06.010
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Fuchshuber, J., & Unterrainer, H. F.. (2020). Childhood Trauma, Personality, and Substance Use Disorder: The Development of a Neuropsychoanalytic Addiction Model. Frontiers in Psychiatry

Plain numerical DOI: 10.3389/fpsyt.2020.00531
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Stevanović, A., Frančišković, T., & Vermetten, E.. (2016). Relationship of early-life trauma, war-related trauma, personality traits, and PTSD symptom severity: A retrospective study on female civilian victims of war. European Journal of Psychotraumatology

Plain numerical DOI: 10.3402/ejpt.v7.30964
DOI URL
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Yalch, M. M., Stewart, A. M., & Dehart, R. M.. (2021). Influence of Betrayal Trauma on Antisocial Personality Disorder Traits. Journal of Trauma and Dissociation

Plain numerical DOI: 10.1080/15299732.2020.1792025
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Paris, J.. (1998). Does childhood trauma cause personality disorders in adults?. Canadian Journal of Psychiatry

Plain numerical DOI: 10.1177/070674379804300203
DOI URL
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Bahari, A., Hasani, J., & Mashhadi Akbar Boojar, M.. (2021). Childhood trauma and type D personality: The endocrine and cardiovascular effects on stress reactivity. Journal of Health Psychology

Plain numerical DOI: 10.1177/1359105320934181
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Rutkowski, K., Dembińska, E., & Walczewska, J.. (2016). Effect of trauma onset on personality traits of politically persecuted victims. BMC Psychiatry

Plain numerical DOI: 10.1186/s12888-016-0853-2
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Sansone, R. A., & Sansone, L. A.. (2007). Childhood trauma, borderline personality, and eating disorders: A development cascade. Eating Disorders

Plain numerical DOI: 10.1080/10640260701454345
DOI URL
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Green, K., & Browne, K.. (2020). Personality Disorder Traits, Trauma, and Risk in Perpetrators of Domestic Violence. International Journal of Offender Therapy and Comparative Criminology

Plain numerical DOI: 10.1177/0306624X19826516
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Li, Y., Lv, Q., Li, B., Luo, D., Sun, X., & Xu, J.. (2020). The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake. BMC Psychiatry

Plain numerical DOI: 10.1186/s12888-020-02844-1
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Back, S. N., Flechsenhar, A., Bertsch, K., & Zettl, M.. (2021). Childhood Traumatic Experiences and Dimensional Models of Personality Disorder in DSM-5 and ICD-11: Opportunities and Challenges. Current Psychiatry Reports

Plain numerical DOI: 10.1007/s11920-021-01265-5
DOI URL
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Sheehan, A. E., Bounoua, N., Miglin, R., Spielberg, J. M., & Sadeh, N.. (2021). A multilevel examination of lifetime aggression: Integrating cortical thickness, personality pathology and trauma exposure. Social Cognitive and Affective Neuroscience

Plain numerical DOI: 10.1093/scan/nsab042
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Watkeys, O. J., Kremerskothen, K., Quidé, Y., Fullerton, J. M., & Green, M. J.. (2018). Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: A systematic review. Neuroscience and Biobehavioral Reviews

Plain numerical DOI: 10.1016/j.neubiorev.2018.08.017
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Light, A. E., Holt-Lunstad, J., Porter, C. L., & Light, K. C.. (2019). Early life trauma: An exploratory study of effects on OXTR and NR3C1 gene expression and nurturing self-efficacy in mothers of infants. International Journal of Psychophysiology

Plain numerical DOI: 10.1016/j.ijpsycho.2018.03.018
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de Assis Pinheiro, J., Freitas, F. V., Borçoi, A. R., Mendes, S. O., Conti, C. L., Arpini, J. K., … Alvares-da-Silva, A. M.. (2021). Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation. Scientific Reports

Plain numerical DOI: 10.1038/s41598-021-86189-z
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Çetin, Ş., Sözeri-Varma, G., Çetin, G. O., Türel, S., Uğurlu, T. T., & Özdel, O.. (2022). The Relationship Between Methylation of the Glucocorticoid Receptor Gene (NR3C1) and Childhood Trauma and Alexithymia. Israel Journal of Psychiatry
Alexander, N., Kirschbaum, C., Wankerl, M., Stauch, B. J., Stalder, T., Steudte-Schmiedgen, S., … Miller, R.. (2018). Glucocorticoid receptor gene methylation moderates the association of childhood trauma and cortisol stress reactivity. Psychoneuroendocrinology

Plain numerical DOI: 10.1016/j.psyneuen.2018.01.020
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Vangeel, E. B., Kempke, S., Bakusic, J., Godderis, L., Luyten, P., Van Heddegem, L., … Claes, S.. (2018). Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients. Journal of Psychosomatic Research

Plain numerical DOI: 10.1016/j.jpsychores.2017.11.011
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Martín-Blanco, A., Ferrer, M., Soler, J., Salazar, J., Vega, D., Andión, O., … Pascual, J. C.. (2014). Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder. Journal of Psychiatric Research

Plain numerical DOI: 10.1016/j.jpsychires.2014.06.011
DOI URL
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Perroud, N., Dayer, A., Piguet, C., Nallet, A., Favre, S., Malafosse, A., & Aubry, J. M.. (2014). Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder. British Journal of Psychiatry

Plain numerical DOI: 10.1192/bjp.bp.112.120055
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Straight, B., Fisher, G., Needham, B. L., Naugle, A., Olungah, C., Wanitjirattikal, P., … Lalancette, C.. (2021). Lifetime stress and war exposure timing may predict methylation changes at NR3C1 based on a pilot study in a warrior cohort in a small-scale society in Kenya. American Journal of Human Biology

Plain numerical DOI: 10.1002/ajhb.23515
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Malhi, G. S., Das, P., Outhred, T., Dobson-Stone, C., Irwin, L., Gessler, D., … Mannie, Z.. (2019). Effect of stress gene-by-environment interactions on hippocampal volumes and cortisol secretion in adolescent girls. Australian and New Zealand Journal of Psychiatry

Plain numerical DOI: 10.1177/0004867419827649
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Smart, C., Strathdee, G., Watson, S., Murgatroyd, C., & McAllister-Williams, R. H.. (2015). Early life trauma, depression and the glucocorticoid receptor gene-an epigenetic perspective. Psychological Medicine

Plain numerical DOI: 10.1017/S0033291715001555
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Qi, R., Luo, Y., Zhang, L., Weng, Y., Surento, W., Xu, Q., … Thompson, P. M.. (2021). Decreased functional connectivity of hippocampal subregions and methylation of the NR3C1 gene in Han Chinese adults who lost their only child. Psychological Medicine

Plain numerical DOI: 10.1017/S0033291720000045
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Schür, R. R., van Leeuwen, J. M. C., Houtepen, L. C., Joëls, M., Kahn, R. S., Boks, M. P., & Vinkers, C. H.. (2018). Glucocorticoid receptor exon 1 F methylation and the cortisol stress response in health and disease. Psychoneuroendocrinology

Plain numerical DOI: 10.1016/j.psyneuen.2018.07.018
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Yehuda, R., Flory, J. D., Bierer, L. M., Henn-Haase, C., Lehrner, A., Desarnaud, F., … Meaney, M. J.. (2015). Lower Methylation of Glucocorticoid Receptor Gene Promoter 1F in Peripheral Blood of Veterans with Posttraumatic Stress Disorder. Biological Psychiatry

Plain numerical DOI: 10.1016/j.biopsych.2014.02.006
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Vangeel, E., Van Den Eede, F., Hompes, T., Izzi, B., Del Favero, J., Moorkens, G., … Claes, S.. (2015). Chronic fatigue syndrome and DNA hypomethylation of the glucocorticoid receptor gene promoter 1F Region: Associations with HPA Axis Hypofunction and childhood trauma. Psychosomatic Medicine

Plain numerical DOI: 10.1097/PSY.0000000000000224
DOI URL
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Fiacco, S., Gardini, E. S., Mernone, L., Schick, L., & Ehlert, U.. (2019). DNA Methylation in Healthy Older Adults With a History of Childhood Adversity—Findings From the Women 40+ Healthy Aging Study. Frontiers in Psychiatry

Plain numerical DOI: 10.3389/fpsyt.2019.00777
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Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., … Malafosse, A.. (2011). Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: A link with the severity and type of trauma. Translational Psychiatry

Plain numerical DOI: 10.1038/tp.2011.60
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Womersley, J. S., Martin, L. I., van der Merwe, L., Seedat, S., & Hemmings, S. M. J.. (2018). Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents. Metabolic Brain Disease

Plain numerical DOI: 10.1007/s11011-017-0138-6
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Rovaris, D. L., Mota, N. R., Bertuzzi, G. P., Aroche, A. P., Callegari-Jacques, S. M., Guimarães, L. S. P., … Grassi-Oliveira, R.. (2015). Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment. Journal of Psychiatric Research

Plain numerical DOI: 10.1016/j.jpsychires.2015.06.008
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Holmes, L., Shutman, E., Chinaka, C., Deepika, K., Pelaez, L., & Dabney, K. W.. (2019). Aberrant epigenomic modulation of glucocorticoid receptor gene (NR3C1) in early life stress and major depressive disorder correlation: Systematic review and quantitative evidence synthesis. International Journal of Environmental Research and Public Health

Plain numerical DOI: 10.3390/ijerph16214280
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Grillault Laroche, D., Curis, E., Bellivier, F., Nepost, C., Courtin, C., Etain, B., & Marie-Claire, C.. (2020). Childhood maltreatment and HPA axis gene expression in bipolar disorders: A gene network analysis. Psychoneuroendocrinology

Plain numerical DOI: 10.1016/j.psyneuen.2020.104753
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Sheerin, C. M., Lind, M. J., Bountress, K. E., Marraccini, M. E., Amstadter, A. B., Bacanu, S. A., & Nugent, N. R.. (2020). Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder. Journal of Traumatic Stress

Plain numerical DOI: 10.1002/jts.22484
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Peng, H., Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., … Zhao, J.. (2018). Childhood Trauma, DNA Methylation of Stress-Related Genes, and Depression: Findings from Two Monozygotic Twin Studies. Psychosomatic Medicine

Plain numerical DOI: 10.1097/PSY.0000000000000604
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Nöthling, J., Malan-Müller, S., Abrahams, N., Hemmings, S. M. J., & Seedat, S.. (2020). Epigenetic alterations associated with childhood trauma and adult mental health outcomes: A systematic review. World Journal of Biological Psychiatry

Plain numerical DOI: 10.1080/15622975.2019.1583369
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Brown, V.. (2021). Methylation of the glucocorticoid receptor gene NR3C1: a summary for clinicians working with children and families. BJPsych Open

Plain numerical DOI: 10.1192/bjo.2021.643
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Joseph Goebbels principles of propaganda

„We enter the Reichstag to arm ourselves with democracy’s weapons. If democracy is foolish enough to give us free railway passes and salaries, that is its problem… We are coming neither as friends or neutrals. We come as enemies! As the wolf attacks the sheep, so come we.“ — Joseph Goebbels

„The people’s community must not be a mere phrase, but a revolutionary achievement following from the radical carrying out of the basic life needs of the working class. A ruthless battle against corruption! A war against exploitation, freedom for the workers! The elimination of all economic-capitalist influences on national policy. Maintaining a rotten economic system has nothing to do with nationalism, which is an affirmation of the Fatherland.“ — Joseph Goebbels

A lesser known fact is that Goebbels stratagems were “inspired” by Edward Bernays (who authored the book entitled “Propaganda” in 1928).

Bernays stated the following in his 1965 autobiography:

They were using my books as the basis for a destructive campaign against the Jews of Germany. This shocked me, but I knew any human activity can be used for social purposes or misused for antisocial ones.


Further References

Doob, L. W.. (1950). Goebbels’ Principles of Propaganda. Public Opinion Quarterly

Plain numerical DOI: 10.1086/266211
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Meyer, M., & Welch, D.. (2006). Propaganda and the German Cinema, 1933-1945. The History Teacher

Plain numerical DOI: 10.2307/493610
DOI URL
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Propaganda and mass persuasion: a historical encyclopedia, 1500 to the present. (2013). Choice Reviews Online

Plain numerical DOI: 10.5860/choice.41-2561
DOI URL
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Herf, J.. (2005). The “jewish War”: Goebbels and the antisemitic campaigns of the Nazi propaganda ministry. Holocaust and Genocide Studies

Plain numerical DOI: 10.1093/hgs/dci003
DOI URL
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Welch, D.. (1993). Manufacturing a consensus: Nazi propaganda and the building of a ‘national community’ (volksgemeinschaft). Contemporary European History

Plain numerical DOI: 10.1017/S096077730000028X
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Erich Fromm – Disobedience: A Moral or Psychological Problem (1962)

Professor-Erich-Fromm-Disobedience-as-a-Psychological-and-Moral-Problem

Secondary literature

Frie, R.. (2003). Erich Fromm and contemporary psychoanalysis: from modernism to postmodernism.. Psychoanalytic Review

Plain numerical DOI: 10.1521/prev.90.6.855.28785
DOI URL
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McLaughlin, N.. (1998). How to become a forgotten intellectual: Intellectual movements and the rise and fall of Erich Fromm. Sociological Forum

Plain numerical DOI: 10.1023/A:1022189715949
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Fromm, E.. (2004). 1929a-e Erich Fromm Psychoanalysis and Sociology. English

Plain numerical DOI: 10.1063/1.4810294
DOI URL
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Rasmussen, B., & Salhani, D.. (2008). Resurrecting erich fromm. Smith College Studies in Social Work

Plain numerical DOI: 10.1080/00377310802111946
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Brookfield, S.. (2002). Overcoming alienation as the practice of adult education: The contribution of Erich Fromm to a critical theory of adult learning and education. Adult Education Quarterly

Plain numerical DOI: 10.1177/0741713602052002002
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Davis, H. B.. (2003). Erich Fromm and postmodernism.. Psychoanalytic Review

Plain numerical DOI: 10.1521/prev.90.6.839.28790
DOI URL
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Psychiatric medical directive

Rosenhan, D. L.. (1974). On being sane in insane places. Clinical Social Work Journal, 2(4), 237–256.

Plain numerical DOI: 10.1007/BF01785781
DOI URL
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It is clear that we cannot distinguish the sane from the insane in psychiatric hospitals. The hospital itself imposes a special environment in which the meanings of behavior can easily be misunderstood. The consequences to patients hospitalized in such an environment-the powerlessness, depersonalization, segregation, mortification, and self-labeling-seem undoubtedly countertherapeutic. I do not, even now, understand this problem well enough to perceive solutions. But two matters seem to have some promise. The first concerns the proliferation of community mental health facilities, of crisis intervention centers, of the human potential movement, and of behavior therapies that, for all of their own problems, tend to avoid psychiatric labels, to focus on specific problems and behaviors, and to retain the individual in a relatively non-pejorative environment. Clearly, to the extent that we refrain from sending the distressed to insane places, our impressions of them are less likely to be distorted. (The risk of distorted perceptions, it seems to me, is always present, since we are much more sensitive to an individual’s behaviors and verbalizations than we are to the subtle contextual stimuli that often promote them. At issue here is a matter of magnitude. And, as I have shown, the magnitude of distortion is exceedingly high in the extreme context that is a psychiatric hospital.) The second matter that might prove promising speaks to the need to increase the sensitivity of mental health workers and researchers to the Catch 22 position of psychiatric patients. Simply reading materials in this area will be of help to some such workers and researchers. For others, directly experiencing the impact of psychiatric hospitalization will be of enormous use. Clearly, further research into the social psychology of such total institutions will both facilitate treatment and deepen understanding. I and the other pseudopatients in the psychiatric setting had distinctly negative reactions. We do not pretend to describe the subjective experiences of true patients. Theirs may be different from ours, particularly with the passage of time and the necessary process of adaptation to one’s environment. But we can and do speak to the relatively more objective indices of treatment within the hospital. It could be a mistake, and a very unfortunate one, to consider that what happened to us derived from malice or stupidity on the part of the staff. Quite the contrary, our overwhelming impression of them was of people who really cared, who were committed and who were uncommonly intelligent. Where they failed, as they sometimes did painfully, it would be more accurate to attribute those failures to the environment in which they, too, found themselves than to personal callousness. Their perceptions and behavior were controlled by the situation, rather than being motivated by a malicious disposition. In a more benign environment, one that was less attached to global diagnosis, their behaviors and judgments might have been more benign and effective.

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The next million years by Charles Galton Darwin

Sir Charles Galton Darwin, KBE, MC, FRS was an English physicist who served as director of the National Physical Laboratory during the Second World War. He was the son of the mathematician George Howard Darwin and a grandson of Charles Darwin. More at Wikipedia

Hormonal modification

“Another type of discovery may be connected with hormones, those internal chemical secretions which so largely regulate the operations of the human body. The artificial use of hormones has already been shown to have profound effects on the behaviour of animals, and it seems quite possible that hormones, or perhaps drugs, might have similar effects on man. For example, there might be a drug, which, without other harmful effects, removed the urgency of sexual desire, and so reproduced in humanity the status of workers in a beehive. Or there might be another drug that produced a permanent state of contentment in the recipient—after all alcohol does something like this already, though it has other disadvantages and is only temporary in its effects. A dictator would certainly welcome the compulsory administration of the “contentment drug” to his subjects.” p183

Oligarchical monopoly

“Widespread wealth can never be common in an overcrowded world, and so in most countries of the future the government will inevitably be autocratic or oligarchic; some will give good government and some bad, and the goodness or badness will depend much more on the personal merits of the rulers than it does in a more democratic country.” p.194

Normative government

“To think of it as possible at other times is a misunderstanding of the function of government in any practical sense of the term. If the only things that a government was required to do were what everybody, or nearly everybody, wanted, there would be no need for the government to exist at all, because the things would be done anyhow; this would be the impracticable ideal of the anarchist. But if there are to be starving margins of population in most parts of the world, mere benevolence cannot suffice. There would inevitably be ill feeling and jealousy between the provinces, with each believing that it was not getting its fair share of the good things, and in fact, it would be like the state of affairs with which we are all too familiar. If then there is ever to be a world government, it will have to function as government do now, in the sense that it will have to coerce a minority – and indeed it may often be a majority – into doing things they do not want to.” p.191

THE NEXT MILLION YEARS
BY
CHARLES GALTON DARWIN
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  • George Pember Darwin (1928–2001) worked developing computers, and then (1964) married Angela Huxley, daughter of David Bruce Huxley. She was also a granddaughter of the writer Leonard Huxley and a great-granddaughter of Thomas Huxley, “Darwin’s Bulldog”.

After the death of his first wife, Leonard married Rosalind Bruce (1890–1994), and had two further sons. The elder of these was David Bruce Huxley (1915-1992), whose daughter Angela Huxley married George Pember Darwin, son of the physicist Sir Charles Galton Darwin (and thus a great-grandson of Charles Darwin married a great-granddaughter of Thomas Huxley). The younger son (1917-2012) was the Nobel Prize winner, physiologist Andrew Fielding Huxley.
en.wikipedia.org/wiki/Huxley_family


Further References

Fancher, R. E.. (2009). Scientific Cousins: The Relationship Between Charles Darwin and Francis Galton. American Psychologist

Plain numerical DOI: 10.1037/a0013339
DOI URL
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Plain numerical DOI: 10.1146/annurev.genet.35.102401.090055
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Plain numerical DOI: 10.1136/jme.24.2.99
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Plain numerical DOI: 10.1038/064659b0
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Plain numerical DOI: 10.1086/374096
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Plain numerical DOI: 10.1016/B978-0-12-374984-0.00060-7
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Plain numerical DOI: 10.1086/521468
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Plain numerical DOI: 10.1111/j.1740-9713.2011.00507.x
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