How strangely will the Tools of a Tyrant pervert the plain Meaning of Words!
— Samuel Adams
Archon (Greek: ἄρχων, romanized: árchōn) is the Greek term for “ruler”. Cognate derivatives are, e.g., terms such as:
anarchy (etymology discussed subsequently in more detail)
According to Aristotle’s Constitution of the Athenians (78-c. 100), the power and influence of the king first devolved to the archons, and these offices were filled from the aristocracy by elections on a decennial basis. Archon Eponymos was the primary magistrate, the Polemarch referred to the head of the armed forces, and the Archon Basileus was in charge of the religious aspects of society.
Various fraternities and sororities use the title of archon or variations on it. Some Gnostic sects used this term for demons associated with the planetspheres.
3-D computer rendering of an “archon”
The term anarchy is the negation of the term archon (i.e., the negatory prefix *a). It thus means “without a ruler/master”, i.e., human beings that do not accept a master and who do not allow others to rule over them (they are not slaves to anyone). Importantly, this derivation should not be confused with “chaos or without rules”. Anarchy simply is the negation of slavery.
Niemand ist mehr Sklave, als der sich für frei hält, ohne es zu sein. ‘
~ Johann Wolfgang von Goethe
(Transl.: None are more hopelessly enslaved than those who falsely believe they are free.)
Human beings who are anarchists are thus literally beings that do not accept to be ruled by archons, i.e., they are free and cannot be ruled and suppressed by external forces (they only subordinate themselves to natural law, viz., the timeless universal metaphysical foundation of morality and ethics; cf. the Kantian categorical imperative).
Act only according to that maxim whereby you can at the same time will that it should become a universal law.
— Immanuel Kant, Grounding for the Metaphysics of Morals (1785)
In this context a quotation by the freedom fighter Malcolm X is of great pertinence.
He asked the following quintessential question concerning the highest of all virtues:
What is the price of freedom?
P.S. This does not imply that one has to die to be free, but it means that one has to be willing to risk once own life for the greatest of all goods, viz., the ultimate expression of human potential: Absolute Freedom.
If one is not willing to go “all in” one has lost the quest for freedom a priori because one is not willing to risk what it takes to achieve it. Fear is the inhibitor of freedom. Death is the mother of all fears. Ergo, overcoming the irrational fear of death is a condicio sine qua non for the obtainment of superordinate transcendental values.
Non-cooperation with evil is a sacred duty.
~ Mahatma Gandhi
Freedom comes with wisdom, intrinsically. They are inseparable, and no society wants people to be free. The communist society, the fascist society, the capitalist society, the Hindu, the Mohammedan, the Christian – no society likes people to use their own intelligence because the moment they start using their intelligence they become dangerous – dangerous to the establishment, dangerous to the people who are in power, dangerous to the “haves”; dangerous to all kinds of oppression, exploitation, suppression; dangerous to the churches, dangerous to the states, dangerous to the nations.
In fact, a wise man is afire, alive, aflame. He would like rather to die than to be enslaved. Death will not matter much to him, but he cannot sell his life to all kinds of stupidities, to all kinds of stupid people. He cannot serve them. Hence, the societies down the ages have been supplying you with false knowing. That’s the very function of your schools, colleges, universities.
They don’t serve you, remember, they serve the past, they serve the vested interests. Of course, they go on puffing your ego up bigger and bigger, they go on giving you more and more degrees. Your name becomes longer and longer, but only the name – you go on becoming shorter and shorter. A point comes where there are only certificates and the man has disappeared. First the man carries the certificates, then the certificates carry the man. The man is long dead.
“Credit suisse research institute is proud to launch the credit suisse global wealth databook 2010, which offers investors the most comprehensive study of world wealth it is the first study to analyze the wealth of all the world’s 4.4 billion adults. research for the credit suisse global wealth databook has been undertaken on behalf of the credit suisse research institute by professors anthony shorrocks and jim davies, recognized authorities on this topic, and the architects and principal authors of ‘personal wealth from a global perspective,’ oxford university press, 2008. the aim of the credit suisse global wealth project is to provide the best available estimates of the wealth holdings of households around the world for the period since the year 2000. while the credit suisse global wealth report highlights the main findings of our study, the 128-page databook underlines the extent of our analysis. more importantly, it sets out in detail the data employed in our global wealth project, the methodology used to calculate estimates of wealth and how this may differ from other reports in this field. the credit suisse global wealth databook also details the evolution of household wealth levels through the period 2000 to 2010, providing data at the regional level on high net worth individuals, and highlighting the wealth pyramid in addition to wealth analysis for 160 countries. finally, the databook presents detailed data on relatively under-researched areas such as gender and the composition of household portfolios (assets and debts).”
Jacobsen, A.. (2015). The Pentagon’s brain : an uncensored history of DARPA, America’s top secret military research agency. Little, Brown US
Show/hide publication abstract
“First edition. since its inception in 1958, the defense advanced research projects agency, or darpa, has grown to become the defense department’s most secret, most powerful, and most controversial military science research and development agency. created by president eisenhower to prevent another sputnik, and to focus primarily on defensive programs against nuclear weapons, the agency–and its imagination and scope–has expanded enormously with each passing year. from agent orange in vietnam to insect-sized drones in use today, from the earliest networked computers and the internet to smart rockets and war zones under 24-hour video surveillance, darpa is responsible for innovations that have changed the course of war, national security, and strategic planning at the highest levels. to uncover the secret history of darpa in action, journalist annie jacobsen tracked down key players in darpa’s smart weapons program, past and present; neuroscientists building an artificial brain, cell biologists working on limb regeneration, the nobel laureate who invented the laser. from darpa’s earliest defensive advances to hundreds of ongoing programs, jacobsen exposes both sides of the darpa coin: the fantastic technological advances from which we all benefit, and the darker side drawn up in a race for military supremacy. based on information from inside sources, exclusive interviews, private documents, and declassified memos, the pentagon’s brain reads like science fiction but is absolutely true, a groundbreaking look behind the scenes at the clandestine intersection of science and the american military.–publisher information. the cold war : the evil thing ; war games and computing machines ; vast weapons systems of the future ; emergency plans ; sixteen hundred seconds until doomsday ; psychological operations — the vietnam war : techniques and gadgets ; rand and coin ; command and control ; motivation and morale ; the jasons enter vietnam ; the electronic fence ; the end of vietnam — operations other than war : rise of the machines ; star wars and tank wars ; the gulf war and operations other than war ; biological weapons ; transforming humans for war — the war on terror : terror strikes ; total information awareness ; ied war ; combat zones that see ; human terrain — future war : drone wars ; brain wars ; the pentagon’s brain.”
Moreno, J. D.. (2012). Mind wars : brain science and the military in the twenty-first century. Bellevue Literary Press
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“Minority report meets dr. strangelove in the true story of how neuroscience and related technologies are shaping national defense. acknowledgments; introduction; 1. darpa on your mind; 2. of machines and men; 3. mind games; 4. how to think about the brain; 5. brain reading; 6. building better soldiers; 7. enter the nonlethals; 8. toward an ethics of neurosecurity; sources; index; about the author.”
Miranda, R. A., Casebeer, W. D., Hein, A. M., Judy, J. W., Krotkov, E. P., Laabs, T. L., … Ling, G. S. F.. (2014). DARPA-funded efforts in the development of novel brain-computer interface technologies.. Journal of Neuroscience Methods, 244, 52–67.
“The defense advanced research projects agency (darpa) has funded innovative scientific research and technology developments in the field of brain-computer interfaces (bci) since the 1970s. this review highlights some of darpa’s major advances in the field of bci, particularly those made in recent years. two broad categories of darpa programs are presented with respect to the ultimate goals of supporting the nation’s warfighters: (1) bci efforts aimed at restoring neural and/or behavioral function, and (2) bci efforts aimed at improving human training and performance. the programs discussed are synergistic and complementary to one another, and, moreover, promote interdisciplinary collaborations among researchers, engineers, and clinicians. finally, this review includes a summary of some of the remaining challenges for the field of bci, as well as the goals of new darpa efforts in this domain.”
„We enter the Reichstag to arm ourselves with democracy’s weapons. If democracy is foolish enough to give us free railway passes and salaries, that is its problem… We are coming neither as friends or neutrals. We come as enemies! As the wolf attacks the sheep, so come we.“ — Joseph Goebbels
„The people’s community must not be a mere phrase, but a revolutionary achievement following from the radical carrying out of the basic life needs of the working class. A ruthless battle against corruption! A war against exploitation, freedom for the workers! The elimination of all economic-capitalist influences on national policy. Maintaining a rotten economic system has nothing to do with nationalism, which is an affirmation of the Fatherland.“ — Joseph Goebbels
A lesser known fact is that Goebbels stratagems were “inspired” by Edward Bernays (who authored the book entitled “Propaganda” in 1928).
Bernays stated the following in his 1965 autobiography:
They were using my books as the basis for a destructive campaign against the Jews of Germany. This shocked me, but I knew any human activity can be used for social purposes or misused for antisocial ones.
Doob, L. W.. (1950). Goebbels’ Principles of Propaganda. Public Opinion Quarterly
“For almost a dozen years german propaganda minister goebbels was recognized as a master of his trade by those who fought and by those who acclaimed the nazi state. this article, based on both the published and unpublished portions of goebbels’ diary, summarizes the major propaganda principles which he followed.”
Meyer, M., & Welch, D.. (2006). Propaganda and the German Cinema, 1933-1945. The History Teacher
“This is the most comprehensive analysis to date of nazi film propaganda in its political, social, and economic contexts, from the pre-war cinema as it fell under the control of the propaganda minister, joseph goebbels, through to the end of the second world war. david welch studies more than one hundred films of all types, identifying those aspects of nazi ideology that were concealed in the framework of popular entertainment.”
Propaganda and mass persuasion: a historical encyclopedia, 1500 to the present. (2013). Choice Reviews Online
“This fascinating survey provides a comprehensive introduction to propaganda, its changing nature, its practitioners, and its impact on the past five centuries of world history. written by leading experts, it covers the masters of the art from joseph goebbels to mohandas gandhi and examines enormously influential works of persuasion such as ‘uncle tom’s cabin,’ techniques such as films and posters, and key concepts like black propaganda and brainwashing. case studies reveal the role of mass persuasion during the reformation, and wars throughout history. regional studies cover propaganda superpowers, such as russia, china, and the united states, as well as little-known propaganda campaigns in southeast asia, ireland, and scandinavia. the book traces the evolution of propaganda from the era of printed handbills to computer fakery, and profiles such brilliant practitioners of the art as third reich film director leni riefenstahl and 19th-century cartoonist thomas nast, whose works helped to bring the notorious boss tweed to justice.”
Herf, J.. (2005). The “jewish War”: Goebbels and the antisemitic campaigns of the Nazi propaganda ministry. Holocaust and Genocide Studies
“How the nazi leadership translated radical antisemitism into a narrative of an innocent, besieged germany striking back at an ‘international jewry’ it accused of starting and prolonging world war ii forms the subject of this study. in the nazis’ paranoid conspiracy theory ‘jewry’ comprised powers behind the scenes in london, moscow, and washington. in response to the ‘war of extermination’ that jewry had supposedly launched against germany, the nazi leadership publicly threatened to ‘exterminate’ and ‘annihilate’ the jews as an act of justified retaliation. in their minds and in their policy, the ideological connection between the ‘final solution’ and the second world war was inherent, rather than contingent. the following analysis suggests why a centuries-old hatred led to mass murder between 1941 and 1945.”
Welch, D.. (1993). Manufacturing a consensus: Nazi propaganda and the building of a ‘national community’ (volksgemeinschaft). Contemporary European History
“The point has to be made at once that any attempt to quantify public reaction to nazi propaganda is fraught with difficulties. accurate measurement of the effectiveness of nazi propaganda is weakened by the absence of public opinion surveys and the fact that, in a society that resorted so readily to coercions and terror, reported opinion did not necessarily reflect the true feelings and moods of the public, especially if these views were opposed to the regime. nevertheless, to state that public opinion in the third reich ceased to exist is not strictly true. after the nazi ‘seizure of power’ in 1933, propaganda minister joseph goebbels stressed the importance of co-ordinating propaganda with other activities. in a dictatorship, propaganda must address itself to large masses of people and attempt to move them to a uniformity of opinion and action. but the nazis also understood that propaganda is of little value in isolation. to some extent this explains why goebbels impressed on all his staff at the ministry of popular enlightenment and propaganda the imperative necessity constantly to gauge public moods. goebbels therefore regularly received (as did all the ruling élites) extraordinarily detailed reports from the secret police (sd reports) about the mood of the people and would frequently quote these in his diary. hitler, too, was familiar with these reports, and his recorded determination to avoid increasing food prices at all costs for fear that this would undermine the regime’s popularity suggests a political sensitivity to public opinion. to assure themselves of continued popular support was an unwavering concern of the nazi leadership, and of hitler and goebbels in particular.”
“The financial crisis, and associated scandals, created a sense of a juridical deficit with regard to the financial sector. forms of independent judgement within the sector appeared compromised, while judgement over the sector seemed unattainable. elites, in the classical millsian sense of those taking tacitly coordinated ‘big decisions’ over the rest of the public, seemed absent. this article argues that the eradication of jurisdictional elites is an effect of neoliberalism, as articulated most coherently by hayek. it characterizes the neoliberal project as an effort to elevate ‘unconscious’ processes over ‘conscious’ ones, which in practice means elevating cybernetic, non- human systems and processes over discursive spheres of politics and judgement. yet such a system still produces its own types of elite power, which come to consist in acts of translation, rather than judgement. firstly, there are ‘cyborg intermediaries’: elites which operate largely within the system of codes, data, screens and prices. secondly, there are ‘diplomatic intermediaries’: elites who come to narrate and justify what markets (and associated technologies and bodies) are ‘saying’. the paper draws on lazzarato’s work on signifying vs asignifying semiotics in order to articulate this, and concludes by considering the types of elite crisis which these forms of power tend to produce.”
Foster, J. B., & Holleman, H.. (2014). The Financial Power Elite. Monthly Review
“The article presents an historical overview of the emergence of the financial sector within the u.s. banking system, focusing on the developments of the end of the 20th century which led to the formation of a financial elite. introductory comments are given noting the rise and fall of different regulatory regimes within the u.s. banking sector in the first half of the century up to 1980. in-depth discussion is then provided highlighting the concentration of the financial sector as a dominant force in the nation’s economy up to the events of the 2008 global financial crisis and the return of political demands for regulation.”
Hoskin, K. W., & Macve, R. H.. (1986). Accounting and the examination: A genealogy of disciplinary power. Accounting, Organizations and Society
“This article uses the example of public sector outsourcing to explore how elite power can be fallible. a contract between the state and private companies repre-sents a complex interweaving of different kinds of power with uncertain outcomes: the experience of outsourcing in the uk and elsewhere is that it frequently goes wrong, with fiascos creating political embarrassment for states and financial problems for companies. drawing on deleuze and guattari, the article explores how the contract is a political device that can be both tool and weapon but which has uncer-tain outcomes. in doing so, it makes a distinctive contribution by arguing that elite work is often about repair and managing the political or financial consequences of failure.”
Seabrooke, L.. (2009). The Social Sources of Financial Power: Domestic Legitimacy and International Financial Orders. Economic Geography
“A state’s financial power is built on the effect its credit, property, and tax policies have on ordinary people: this is the key message of leonard seabrooke’s comparative historical investigation, which turns the spotlight away from elite financial actors and toward institutions that matter for the majority of citizens. seabrooke suggests that everyday contests between social groups and the state over how the economy should work determine the legitimacy of a state’s financial and fiscal system. ideally, he believes, such contests compel a state to intervene on behalf of people below the median income level, leading the state to broaden and deepen its domestic pool of capital while increasing its influence on international finance. but to do so, seabrooke asserts, a state must first challenge powerful interests that benefit from the concentration of financial wealth.seabrooke’s novel constructivist approach is informed by economic sociology and the work of max weber. this book demonstrates how domestic legitimacy influences the character of international financial orders. it will interest all readers concerned with how best to transform state intervention in the economy for the good of the majority.”
Davis, A.. (2000). Public relations, business news and the reproduction of corporate elite power. Journalism
“This article discusses the rise of corporate public relations in britain and offers an alternative explanation of how it has benefited the corporate sector. most assessments of corporate pr tend to support traditional radical media accounts of strong corporate influence over media production and public opinion. all either argue or assume that pr is an effective form of ‘mind control’ with which to influence ‘the masses’. against this account, this article instead argues that corporate pr has been more frequently used to gain a competitive advantage over rivals and has been primarily targeted at other corporate elites. this corporate elite focus has worked to further exclude non- corporate elites from participation in the production of financial and business news. as a result, a more general corporate advantage has been gained as much by exclusion as persuasion of the general public. after a brief discussion of the evidence and debates, these conclusions are illustrated with a case study of the granada take-over of forte in 1995–96.”
Boswell, R.. (2005). Identities: Global Studies in Culture and Power. Global Studies in Culture and Power
“Development was long viewed in reductionist economic terms. critical assessment of performance eventually led to making development debates multidimensional and multidisciplinary. it was belatedly recognized that development is a value-laden issue demanding explicitly ethical analysis. dominant patterns of development are not equitable; they must not be sustained. sustainability is needed in economic, social, political, and cultural arenas. ethically based development calls for a reversal of the inversion of means and ends by development actors. as the undp notes, economic development is a means to a broader end: qualitative human development. pursuing economic development as an end leads to serious distortions. correction requires using market competition as a social mechanism, not as an operating principle. globalization produces good and bad effects. the entry into arenas of development decision-making of new actors—ngos and other agents of civil society—reframes the terms of development debates. there are growing demands from affected populations and institutional actors in civil society to define their own development. this challenges elite decision-making of dominant international financial institutions, great power governments, and large international business firms.”
Abbink, J., & Salverda, T.. (2012). The anthropology of elites: Power, culture, and the complexities of distinction. The Anthropology of Elites: Power, Culture, and the Complexities of Distinction
“A fascinating array of ethnographic and theoretical relevant case studies, this book is timely and topical in combining substantial new historical and ethnographic material about elites. case studies include the polish gentry, the white former colonial elite of mauritius, professional elites, and transnational (financial) elites, with queries about power, culture, distinction and marginalization. the focus on elites from an anthropological perspective makes a significant contribution to explaining numerous and often paradoxical aspects of elites, their behavior, their position and their relationship with other social groupings.”
The individual comes face-to-face with a conspiracy so monstrous he cannot believe it exists. The American mind has not come to a realisation of the evil which has been introduced into our midst. It rejects even the assumption that human creatures could espouse a philosophy which must ultimately destroy all that is good and decent.
When morals decline and good men do nothing, evil flourishes. A society unwilling to learn from past is doomed. We must never forget our history.
John Edgar Hoover was an American law enforcement administrator and the first Director of the Federal Bureau of Investigation of the United States. He was appointed as the director of the Bureau of Investigation – the FBI’s predecessor – in 1924 and was instrumental in founding the FBI in 1935, where he remained director until his death in 1972 at the age of 77
Take first the question of food and population. At present
the population of the globe is increasing at the rate of about
20 millions a year. Most of this increase is in Russia and
Southeast Asia. The population of Western Europe and
the United States is nearly stationary. Meanwhile, the food
supply of the world as a whole threatens to diminish, as a
result of unwise methods of cultivation and destruction of
forests. This is an explosive situation. Left to itself, it must
lead to a food shortage and thence to a world war. Technique,
however, makes other issues possible.
Vital statistics in the West are dominated by medicine
and birth control: the one diminishes the deaths, the other
the births. The result is that the average age in the West
increases: there is a smaller percentage of young people and
a larger percentage of old people. Some people consider that
this must have unfortunate results, but speaking as an old
person, I am not sure.
The danger of a world shortage of food may be averted
for a time by improvements in the technique of agriculture.
But, if population continues to increase at the present rate,
such improvements cannot long suffice. There will then be
two groups, one poor with an increasing population, the
other rich with a stationary population. Such a situation can
hardly fail to lead to world war. If there is not to be an
endless succession of wars, population will have to become
stationary throughout the world, and this will probably have
to be done, in many countries, as a result of governmental
measures. This will require an extension of scientific tech-
nique into very intimate matters. There are, however, two
other possibilities. War may become so destructive that, at
any rate for a time, there is no danger of overpopulation; or
the scientific nations may be defeated and anarchy may de-
stroy scientific technique.
Biology is likely to affect human life through the study of
heredity. Without science, men have changed domestic
animals and food plants enormously in advantageous ways.
It may be assumed that they will change them much more,
and much more quickly, by bringing the science of genetics
to bear. Perhaps, even, it may become possible artificially to
induce desirable mutations in genes. (Hitherto the only muta-
tions that can be artificially caused are neutral or harmful.)
In any case, it is pretty certain that scientific technique will
very soon effect great improvements in the animals and
plants that are useful to man.
When such methods of modifying the congenital character
of animals and plants have been pursued long enough to make
their success obvious, it is probable that there will be a
powerful movement for applying scientific methods to human
propagation. There would at first be strong religious and
emotional obstacles to the adoption of such a policy. But sup-
pose (say) Russia were able to overcome these obstacles
and to breed a race stronger, more intelligent, and more
resistant to disease than any race of men that has hitherto
existed, and suppose the other nations perceived that unless
they followed suit they would be defeated in war, then either
the other nations would voluntarily forgo their prejudices, or,
after defeat, they would be compelled to forgo them. Any
scientific technique, however beastly, is bound to spread if
it is useful in war— until such time as men decide that they have
had enough of war and will henceforth live in peace. As
that day does not seem to be at hand, scientific breeding of
human beings must be expected to come about. I shall return
to this subject in a later chapter.
Physiology and psychology afford fields for scientific tech-
nique which still await development. Two great men, Pavlov
and Freud, have laid the foundation. I do not accept the view
that they are in any essential conflict, but what structure
will be built on their foundations is still in doubt.
I think the subject which will be of most importance polit-
ically is mass psychology. Mass psychology is, scientifically
speaking, not a very advanced study, and so far its professors
have not been in universities: they have been advertisers,
politicians, and, above all, dictators. This study is immensely
useful to practical men, whether they wish to become rich
or to acquire the government. It is, of course, as a science,
founded upon individual psychology, but hitherto it has
employed rule-of-thumb methods which were based upon a
kind of intuitive common sense. Its importance has been
enormously increased by the growth of modern methods of
propaganda. Of these the most influential is what is called
"education." Religion plays a part, though a diminishing one;
the press, the cinema, and the radio play an increasing part.
What is essential in mass psychology is the art of per-
suasion. If you compare a speech of Hitler's with a speech of
(say) Edmund Burke, you will see what strides have been
made in the art since the eighteenth century. What went
wrong formerly was that people had read in books that man
is a rational animal, and framed their arguments on this
hypothesis. We now know that limelight and a brass band
do more to persuade than can be done by the most elegant
train of syllogisms. It may be hoped that in time anybody will
be able to persuade anybody of anything if he can catch
the patient young and is provided by the State with money
Man muß das Wahre immer wiederholen, weil auch der Irrtum um uns her immer wieder gepredigt wird, und zwar nicht von einzelnen, sondern von der Masse. In Zeitungen und Enzyklopädien, auf Schulen und Universitäten, überall ist der Irrtum oben auf, und es ist ihm wohl und behaglich, im Gefühl der Majorität, die auf seiner Seite ist. ~ Johann Wolfgang von Goethe
(Transl.: Truth has to be repeated constantly, because Error also is being preached all the time, and not just by a few, but by the multitude. In the Press and Encyclopaedias, in Schools and Universities, everywhere Error holds sway, feeling happy and comfortable in the knowledge of having Majority on its side.)
The following statistical tools are of great value in this context because they enable researchers to investigate Wikipedia (e.g., “Edit Wars”) in an empirical fashion (see also Aceto & Pescapé, 2015; Darer, Farnan, & Wright, 2018; Gosain, Agarwal, Shekhawat, Acharya, & Chakravarty, 2018; Wright, Darer, & Farnan, 2018):
Darer, A., Farnan, O., & Wright, J. (2018). Automated discovery of internet censorship by web crawling. In WebSci 2018 – Proceedings of the 10th ACM Conference on Web Science. doi.org/10.1145/3201064.3201091
Gosain, D., Agarwal, A., Shekhawat, S., Acharya, H. B., & Chakravarty, S. (2018). Mending wall: On the implementation of censorship in India. In Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST. doi.org/10.1007/978-3-319-78813-5_21
Wright, J., Darer, A., & Farnan, O. (2018). On identifying anomalies in tor usage with applications in detecting internet censorship. In WebSci 2018 – Proceedings of the 10th ACM Conference on Web Science. doi.org/10.1145/3201064.3201093
The nucleus accumbens has a significant role in the cognitive processing of motivation, aversion, reward (i.e., incentive salience, pleasure, and positive reinforcement), and reinforcement learning (e.g., Pavlovian-instrumental transfer).
Sagittal MRI slice with highlighting (red) indicating the nucleus accumbens.
The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for nucleus adjacent to the septum) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus. The nucleus accumbens and the olfactory tubercle collectively form the ventral striatum. The ventral striatum and dorsal striatum collectively form the striatum, which is the main component of the basal ganglia.The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium spiny neurons of the nucleus accumbens and olfactory tubercle. Each cerebral hemisphere has its own nucleus accumbens, which can be divided into two structures: the nucleus accumbens core and the nucleus accumbens shell. These substructures have different morphology and functions.
Different NAcc subregions (core vs shell) and neuron subpopulations within each region (D1-type vs D2-type medium spiny neurons) are responsible for different cognitive functions. As a whole, the nucleus accumbens has a significant role in the cognitive processing of motivation, aversion, reward (i.e., incentive salience, pleasure, and positive reinforcement), and reinforcement learning (e.g., Pavlovian-instrumental transfer); hence, it has a significant role in addiction. In addition, part of the nucleus accumbens core is centrally involved in the induction of slow-wave sleep. The nucleus accumbens plays a lesser role in processing fear (a form of aversion), impulsivity, and the placebo effect. It is involved in the encoding of new motor programs as well.
“Social behaviours in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviours, the neural mechanisms by which social reward is encoded by the brain are largely unknown. here we demonstrate that in mice oxytocin acts as a social reinforcement signal within the nucleus accumbens core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons. although the nucleus accumbens receives oxytocin-receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe nucleus, which provides serotonergic (5-hydroxytryptamine; 5-ht) innervation to the nucleus accumbens, abolishes the reinforcing properties of social interaction. furthermore, oxytocin-induced synaptic plasticity requires activation of nucleus accumbens 5-ht1b receptors, the blockade of which prevents social reward. these results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-ht in the nucleus accumbens, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.”
Trezza, V., Damsteegt, R., Achterberg, E. J. M., & Vanderschuren, L. J. M. J.. (2011). Nucleus Accumbens -Opioid Receptors Mediate Social Reward. Journal of Neuroscience
“Positive social interactions are essential for emotional well-being and proper behavioral development of young individuals. here, we studied the neural underpinnings of social reward by investigating the involvement of opioid neurotransmission in the nucleus accumbens (nac) in social play behavior, a highly rewarding social interaction in adolescent rats. intra-nac infusion of morphine (0.05-0.1 μg) increased pinning and pouncing, characteristic elements of social play behavior in rats, and blockade of nac opioid receptors with naloxone (0.5 μg) prevented the play-enhancing effects of systemic morphine (1 mg/kg, s.c.) administration. thus, stimulation of opioid receptors in the nac was necessary and sufficient for morphine to increase social play. intra-nac treatment with the selective μ-opioid receptor agonist [d-ala(2),n-mephe(4),gly(5)-ol]enkephalin (damgo) (0.1-10 ng) and the μ-opioid receptor antagonist cys-tyr-d-trp-arg-thr-pen-thr-nh(2) (ctap) (0.3-3 μg) increased and decreased social play, respectively. the δ-opioid receptor agonist dpdpe ([d-pen(2),d-pen(5)]-enkephalin) (0.3-3 μg) had no effects, whereas the κ-opioid receptor agonist u69593 (n-methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]dec-8-yl]acetamide) (0.01-1 μg) decreased social play. intra-nac treatment with β-endorphin (0.01-1 μg) increased social play, but met-enkephalin (0.1-5 μg) and the enkephalinase inhibitor thiorphan (0.1-1 μg) were ineffective. damgo (0.1-10 ng) increased social play after infusion into both the shell and core subregions of the nac. last, intra-nac infusion of ctap (3 μg) prevented the development of social play-induced conditioned place preference. these findings identify nac μ-opioid receptor stimulation as an important neural mechanism for the attribution of positive value to social interactions in adolescent rats. altered nac μ-opioid receptor function may underlie social impairments in psychiatric disorders such as autism, schizophrenia, or personality disorders.”
Day, J. J., Roitman, M. F., Wightman, R. M., & Carelli, R. M.. (2007). Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nature Neuroscience
“The ability to predict favorable outcomes using environmental cues is an essential part of learned behavior. dopamine neurons in the midbrain encode such stimulus-reward relationships in a manner consistent with contemporary learning models, but it is unclear how encoding this translates into actual dopamine release in target regions. here, we sampled dopamine levels in the rat nucleus accumbens on a rapid (100 ms) timescale using electrochemical technology during a classical conditioning procedure. early in conditioning, transient dopamine-release events signaled a primary reward, but not predictive cues. after repeated cue-reward pairings, dopamine signals shifted in time to predictive cue onset and were no longer observed at reward delivery. in the absence of stimulus-reward conditioning, there was no shift in the dopamine signal. consistent with proposed roles in reward prediction and incentive salience, these results indicate that rapid dopamine release provides a reward signal that is dynamically modified by associative learning.”
Wise, R.. (1989). Brain Dopamine And Reward. Annual Review of Psychology
“While the evidence is strong that dopamine plays some fundamental and special role in the rewarding effects of brain stimulation, psychomotor stimulants, opiates, and food, the exact nature of that role is not clear. one thing is clear: dopamine is not the only reward transmitter, and dopaminergic neurons are not the final common path for all rewards. dopamine antagonists and lesions of the dopamine systems appear to spare the rewarding effects of nucleus accumbens and frontal cortex brain stimulation (simon et al 1979) and certainly spare the rewarding effects of apomorphine (roberts & vickers 1988). it is clear that reward circuitry is multisynaptic, and since dopamine cells do not send axons to each other or receive axons from each other, dopamine can at best serve as but a single link in this circuitry. if dopamine is not a final common path for all rewards, could it be an intermediate common path for most rewards? some workers have argued against such a view, but at present they must do so on incomplete evidence. for example, phillips (1984) has argued that there must be multiple reward systems, functionally independent and organized in parallel with one another. his primary evidence, however, is the fact that brain stimulation is rewarding at different levels of the nervous system. as we have seen in the case of midline mesencephalic stimulation, the location of the electrode tip in relation to the dopamine cells and fibers tells us little about the role of dopamine in brain stimulation reward. it seems clear that the ventral tegmental dopamine system plays a critical role in midline mesencephalic reward, despite the distance from the electrode tip to the dopamine cells where morphine causes its dopamine-dependent facilitory effects or to the dopamine terminals where low-dose neuroleptics presumably cause theirs. until pharmacological challenge has been extended to the cases discussed by phillips, we can only speculate as to the role of dopamine in each of those cases. in the cases where pharmacological challenge has been examined, only nucleus accumbens and frontal cortex have been found to have dopamine-independent reward sites. it is not consistent with the dopamine hypothesis that dopamine-independent reward sites should exist in these areas, since any reward signals carried to nucleus accumbens or frontal cortex by dopamine fibers would-unless we are to believe that reward ‘happens’ at these sites-have to be carried to the next stage of the c…”
www.uni-kiel.de/psychologie/mausfeld/ Mausfeld_Why do the lambs remain silent_2015
Mausfeld focuses on perceptual psychology and also works on the theoretical foundations of experimental psychology and the psychology of understanding. He also deals with the rivalry of cognitive psychology and cognitive neuroscience in cognitive science. Another area of interest is the history of ideas in the natural sciences. He sees a major problem of the relationship between psychology and biology in neurological neo-reductionism. In contrast to biologistic approaches, he sees the peculiarity of the spiritual, inter alia, in the intrinsic multiperspectivity of the mind.
Mausfeld points out that knowledge of neural circuitry and activity is not enough to explain consciousness and thought processes. Not even the behavior of nematodes can be deduced from the activity of their 302 neurons. According to Mausfeld’s view, the relationship between nature and mind must be below the neural level in the sphere of physics. Evidence is given by the fact that nature is actually more enigmatic to us than our consciousness in itself. In modern physics it has become clear that the physical does not have the properties of matter ascribed to it. Mausfeld sees the special aspect of consciousness in the simplicity and wholeness of the subjective experience, which, however, reveals itself to the psychologist as a complex interaction of unconscious factors. The intrinsic multiperspectivity of thinking, which first opens up the possibilities for thought and action alternatives to humans after mouse field, results from the complex interplay of the most varied of factors. White torture and responsibility of science
In his work, Mausfeld illustrates the role of psychologists in the development, application and justification of modern white torture methods. These goals are not, as claimed, the extraction of information, but rather breaking the will, disciplining, humiliating and shaming the victims. In his account, an American Psychological Association (APA) working group to investigate the involvement of psychologists acting on behalf of the Defense Secretary. Mausfeld uses the example of torture research to define ethical and legal principles and limits of scientific work. He regards the observance of human rights as fully binding.
Mausfeld, R.. (2009). Psychology , ’ white torture ’ and the responsibility of scientists. Psychologische Rundschau
According to Mausfeld, the cognitive ones are more important than the affective techniques, since opinions are more stable than emotions. Here Mausfeld examines the following methods:
Representation of facts as opinion
Fragmenting coherent facts so that the context, such as the historical context, is lost
Decontextualization of facts: The context of the facts is removed, so that the facts become incomprehensible isolated individual cases, which have no general relevance
Misleading recontextualization: Information is embedded in a foreign context, so that they take on a different character and, for example, no longer lead to outrage in human rights violations.
Repetition supports the “perceived truth”
Designing the range of opinions so that the desired seems to be in the middle, which most people strive for, if they are unfamiliar, because they then keep to the middle seein it as “neutral and balanced”
Making facts invisible through media selection, distraction and attention control
“Meta-propaganda”: It is part of every propaganda to claim that the news of the enemy is wrong because it is propaganda
The development of more efficient manipulation techniques rests on identifying psychological “weak spots” – those intrinsic design aspects of our mind and principles of human information processing that can be exploited for manipulation purposes. Most importantly, such principles are, by the very nature of our cognitive architecture, beyond conscious control. (…) Our mind has many hard-wired weaknesses that can be exploited for manipulative purposes, that facilitate our utilitarian abuse by the political and economic elites for maintaining and expanding their power. However, we also innately dispose of a rich repertoire of ways to use our reasoning capabilities to recognize manipulative contexts and to actively avoid them. This repertoire is akin to a natural cognitive immune system against being manipulated, but we have to take the deliberate decision to actually use it.
“The cognitive neurosciences are based on the idea that the level of neurons or neural networks constitutes a privileged level of analysis for the explanation of mental phenomena. this paper brings to mind several arguments to the effect that this presumption is ill-conceived and unwarranted in light of what is currently understood about the physical principles underlying mental achievements. it then scrutinizes the question why such conceptions are nevertheless currently prevailing in many areas of psychology. the paper argues that corresponding conceptions are rooted in four different aspects of our common-sense conception of mental phenomena and their explanation, which are illegitimately transferred to scientific enquiry. these four aspects pertain to the notion of explanation, to conceptions about which mental phenomena are singled out for enquiry, to an inductivist epistemology, and, in the wake of behavioristic conceptions, to a bias favoring investigations of input-output relations at the expense of enquiries into internal principles. to the extent that the cognitive neurosciences methodologically adhere to these tacit assumptions, they are prone to turn into a largely a-theoretical and data-driven endeavor while at the same time enhancing the prospects for receiving widespread public appreciation of their empirical findings.”
Mausfeld, R., & Heyer, D.. (2012). Colour Perception: Mind and the physical world. Colour Perception: Mind and the Physical World
“ContentsnPrefacen1. perspectives on colour space , jan j. koenderink and andrea j. van doornncommentaries: from physics to perception through colorimetry: a bridge too far? , donald i.a. macleodncolorimetry fortified , paul whittlen2. light adaptation, contract adaptation, and human colour vision , michael a. websterncommentary: adaptation and the ambiguity of response measures with respect to internal structure , franz fauln3. contrast colours , paul whittlencommentaries: a background to color vision , michael a. websterncontrast coding and what else? , hans irteln4. colour and the processing of chromatic information , michael d’zmurancommentary: the processing of chromatic information , laurence t. maloneyn5. the pleistochrome: optimal opponent codes for natural colours , donald i.a. macleod and t. von der twerncommentary: thinking outside the black box , michael a. webstern6. objectivity and subjectivity revisited: colour as a psychobiological property , gary hatfieldncommentary: why is this game still being played? , paul whittlen7. a computational analysis of colour constancy , donald i.a. macleod and jurgen golzncommentary: the importance of realistic models of surface and light in the study of human colour vision , laurence t. maloneyn8. backgrounds and illuminants: the yin and yang of colour constancy , richard o. brownncommentaries: colour construction , don hoffmannfitting linear models to data , laurence t. maloneyn9. surface colour perception and environmental constraints , laurence t. maloneyncommentaries: on the function of colour vision , gary hatfieldnintrinsic colours – and what it is like to see them , zoltan jacobn10. colour constancy: developing empirical tests of computational models , david h. brainard, james m. kraft, and philippe longerencommentaries: surface colour perception and its environments , laurence t. maloneyncomparing the behaviour of machine vision algorithms and human observers , vebjorn ekroll and jurgen golzn11. the illuminant estimation hypothesis and surface colour perception , laurence t. maloney and joong nam yangncommentary: surface colour appearance in nearly natural images , david h. brainardn12. the interaction of colour and motion , donald d. hoffmanncommentary: the interaction of perceived colour and perceived motion , richard brownn13. the dual coding of colour: ‘Surface colour’ and ‘illumination colour’ as constituents of the representationalformat of perceptual primitives…”
Mausfeld, R.. (2005). The Physicalistic Trap in Perception Theory. In Perception and the Physical World
“This chapter contains sections titled: * introduction * the physicalistic trap in elementaristic approaches to perception * the physicalistic trap in functionalist and computational approaches to perception * perception theory beyond the physicalistic trap * appendix * acknowledgement * notes * references”
Mausfeld, R.. (2012). Der Schein des Realen.. Näher Dran? Zur Phänomenologie Des Wahrnehmens
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“Die traditionelle wahrnehmungspsychologie hat durch ihre physiologistische und physikalistische orientierung und die damit verbundene fokussierung auf elementaristische wahrnehmungsattribute die interne struktur der wahrnehmung und damit die explanatorischen aufgaben der wahrnehmungs- psychologie in grundlegender weise mißverstanden. ihre zugangsweise ist nicht nur phänomenolo- gisch inadäquat, sondern hat sich auch explanatorisch als unfruchtbar erwiesen. dieser beitrag zeigt dies am beispiel des wahrnehmungsattributs ‚phänomenal real’ auf, das in der traditionellen wahr- nehmungspsychologie als wenig erklärungsbedürftig angesehen wird. tatsächlich stellt jedoch ‚real‘ ein internes attribut dar, dessen zuweisung zu wahrnehmungsobjekten und situationen eigenen psychologischen gesetzmäßigkeiten folgt, die sich aus physiologistischer und physikalistischer per- spektive nicht verstehen lassen. erst in den letzten jahren wird im zusammenhang mit problemen, die sich insbesondere bei virtual reality environments ergeben, die frage nach den auslösebedingungen für das attribut ‚real’ wieder thematisiert. offensichtlich verfügt unser wahrnehmungssystem über eine (biologisch vorgegebene und kulturell überformte) ‚interne semantik‘ für die zuschreibung des attributes ‚real‘, von deren komplexen möglichkeiten wir in der kultur (z.b. beim film oder theater) vielfältigen gebrauch machen. i.”
Mausfeld, R.. (2009). Psychologie, weiße folter’ und die verantwortlichkeit von wissenschaftlern. Psychologische Rundschau
“The disparity of highlights on specular reflecting surfaces usually differs from the disparity of the surface points. a. kirschmann (1895) proposed that this fact may be used as a binocular cue for gloss perception. this was confirmed by a. blake and h. bülthoff (1990) who found that subjects judged the glossiness of convex ellipsoidal surfaces as most realistic if the disparity of the highlights was close to the physical correct one. extending on this finding, we investigate more closely whether the effect of highlight disparity depends on the sharpness of the highlight and the relative amount of diffuse and specular reflection. we measured the effect of highlight disparity on both perceived strength and perceived authenticity of gloss. we used complex, three-dimensional curved surfaces that were stereoscopically presented on a crt. the reflection characteristics were varied using the phong lighting model. highlights were presented either with or without highlight disparity. in a rating experiment, subjects were asked to judge the strength and the authenticity of the perceived surface glossiness. the presence of highlight disparity lead to an enhancement of both the authenticity and the strength of perceived glossiness. the latter finding was confirmed in an additional matching experiment.”
Mausfeld, R.. (2010). Psychologie, biologie, kognitive neurowissenschaften zur gegenwärtigen dominanz neuroreduktionistischer positionen zu ihren stillschweigenden grundannahmen. Psychologische Rundschau
“The cognitive neurosciences are based on the idea that the level of neurons constitutes a privileged level of analysis for the explanation of mental phenomena. this paper brings to mind several arguments to elucidate that this presumption is ill-conceived and unwarranted in light of what is currently understood about the physical principles underlying mental achievements. it then scrutinizes the question why nevertheless such conceptions are currently prevailing in many areas of psychology. the paper argues that neuroreductionist conceptions are rooted in four different aspects of our common-sense conception of mental phenomena and their explanation that are illegitimately transferred to scientific inquiry. these four aspects pertain to the notion of explanation, to conceptions about which mental phenomena are singled out for inquiry, to an inductivist epistemology, and, in the wake of behavioristic conceptions, to a bias favoring investigations of input-output relations at the expense of inquiries into internal principles. to the extent that the cognitive neurosciences methodologically adhere to these tacit assumptions, they are prone to turn into a largely atheoretical and data-driven endeavour while at the same time receiving wide-spread public appreciation of their empirical findings. (psycinfo database record (c) 2012 apa, all rights reserved)”
Heyer, D., & Mausfeld, R.. (2002). Perception and the physical world: psychological and philosophical issues in perception. Perception
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“The focus of this book is on conceptual and philosophical issues of perception including the classic notion of unconscious inferences in perception. the book consists of contributions from a group of internationally renowned researchers who spent a year together as distinguised fellows at the german centre for advanced study. each chapter concludes with a lively, informative debate in the form of comments and replies from the contributors of the book. contributors are of prominent international reputation each chapter concludes with comments and replies from the contributors of the book to give informative debate the only book available to blend perception and philosophy in this fashion”
Narens, L., & Mausfeld, R.. (1992). On the Relationship of the Psychological and the Physical in Psychophysics. Psychological Review
“Presents a theory of the relationship of the psychological and the physical and uses it to formulate a new kind of meaningfulness principle for psychophysical application. this new principle calls into question the psychological relevance of many kinds of quantitative psychophysical relationships. as an illustration, it is used to study comparisons of sensitivity involving weber fractions, particularly comparisons across sensory modalities. the methods of the illustration extend easily to other psychophysical situations. (psyclit database copyright 1992 american psychological assn, all rights reserved)”
Mausfeld, R.. (2012). “Colour” As Part of the Format of Different Perceptual Primitives: The Dual Coding of Colour. In Colour Perception: Mind and the Physical World
“The field of colour perception has often been praised in recent years as a paradigm of cognitive science. while this certainly has some validity, it contrasts with the fact that the field makes very little contact with the sort of inquiries into mental representations to be found elsewhere in cognitive science (understood as naturalistic inquiries of the mind/brain). i find this quite puzzling, because in the earlier literature of the field it was clearly recognised-for instance by bühler, gelb, kardos, koffka-that ʹcolourʹ could be understood only as part of the general problem of perceptual representations. their insights could not, of course, take advantage of the theoretical language provided by what has been called the cognitive revolution. for that reason, and also because they were overshadowed by the success of more technical fields, they fell almost entirely into oblivion. the technical fields, successful with respect to their own specific goals, were colorimetry, neurophysiological investigations into peripheral colour coding, and more recently, functionalist-computational approaches that emphasise certain pre-given performance criteria.. the success of these fields has not been hampered by the fact that they share certain common-sense conceptions of colour, particularly the idea that colour is an autonomous attribute that can be studied almost in isolation from other perceptual attributes. because such common-sense conceptions of colour appear to be, by and large, innocuous to advances in these fields, no need has arisen so far to relinquish them. however, precisely because of the successes of these fields inquiries into colour perception, understood as the endeavour to develop explanatory frameworks for the role of ʹcolourʹ within our perceptual and cognitive architecture, have suffered a less fortunate fate. the conceptual vocabulary which inquiries into colour perception 1 borrowed from fields, such as neurophysiology, that pursue different explanatory purposes has remained alien to its intrinsic structure and has veiled its core problems. my interest in colour perception (which, a long time ago, was incited by russellʹs problems of philosophy) has been motivated by the question of how we can, within naturalistic inquiry, describe the conceptual structure with which our perceptual system is biologically endowed. such questions have long been pursued in ethology and have yielded intriguing results. the theoretical picture that is emerging h…”
Mausfeld, R.. (2013). The Attribute of Realness and the Internal Organization of Perceptual Reality. In Handbook of Experimental Phenomenology: Visual Perception of Shape, Space and Appearance
“The chapter deals with the notion of phenomenal realness, which was first systematically explored by albert michotte. phenomenal realness refers to the impression that a perceptual object is perceived to have an autonomous existence in our mind-independent world. perceptual psychology provides an abundance of phenomena, ranging from amodal completion to picture perception, that indicate that phenomenal realness is an independent perceptual attribute that can be conferred to perceptual objects in different degrees. the chapter outlines a theoretical framework that appears particularly well-suited for dealing with corresponding phenomena. according to this framework, perception can be under- stood as a triggering of conceptual forms by sensor inputs. it is argued that the attribute of phenomenal realness is based on specific types of internal evaluation functions which deal with the segregation of causes conceived as ‘external’ from those conceived as ‘internal’. these evaluation functions integrate different internal sources of ‘knowledge’ about the potential causes for the activation of conceptual forms and provide markers by which conceptual forms can be tagged as ‘external world objects’. ‘reality’,”
Mausfeld, R.. (2001). What’s within? Can the internal structure of perception be derived from regularities of the external world?. Behavioral and Brain Sciences
“We argue, from an ethology-inspired perspective, that the internal concepts ‘surface colours’ and ‘illumination colours’ are part of the data format of two different representational primitives. thus, the internal concept of ‘colour’ is not a unitary one but rather refers to two different types of ‘data structure’, each with its own proprietary types of parameters and relations. the relation of these representational structures is modulated by a class of parameterised transformations whose effects are mirrored in the idealised computational achievements of illumination invariance of colour codes, on the one hand, and scene invariance, on the other hand. because the same characteristics of a light array reaching the eye can be physically produced in many different ways, the visual system, then, has to make an ‘inference’ whether a chromatic deviation of the space-averaged colour codes from the neutral point is due to a ‘non-normal’, ie chromatic, illumination or due to an imbalanced spectral reflectance composition. we provide evidence that the visual system uses second-order statistics of chromatic codes of a single view of a scene in order to modulate corresponding transformations. in our experiments we used centre surround configurations with inhomogeneous surrounds given by a random structure of overlapping circles, referred to as seurat configurations. each family of surrounds has a fixed space-average of colour codes, but differs with respect to the covariance matrix of colour codes of pixels that defines the chromatic variance along some chromatic axis and the covariance between luminance and chromatic channels. we found that dominant wavelengths of red-green equilibrium settings of the infield exhibited a stable and strong dependence on the chromatic variance of the surround. high variances resulted in a tendency towards ‘scene invariance’, low variances in a tendency towards ‘illumination invariance’ of the infield.”
Mausfeld, R.. (2006). Wahrnehmung: Geschichte und Ansätze. In Handbuch der Allgemeinen Psychologie – Kognition
“The interpretation of the role of hla-dpb1 in unrelated haematopoietic stem cell transplantation (hsct) is subject to discussion. we have investigated the role of hla-dpb1 allele matching in hsct outcomes in 161 recipients who were hla-a, -b, -c, -drb1 and -dqb1-matched with their unrelated donors at the allelic level (10/10). in addition, we analysed the association of polymorphic amino acid mismatches of dpb1 molecule with hsct end-points, and a previously published permissiveness concept. hla-dpb1 allele mismatches were significantly associated with an increased incidence of acute graft-versus-host disease (agvhd) and worse overall survival (os). the mismatch at amino acid position 69 significantly increased the risk for transplant-related mortality (trm). risk factors for agvhd also included mismatches at positions 8, 9, 35, 76 and 84. this is to our knowledge, the first report of an in vivo effect of single amino acid mismatches on hsct outcomes. in this study, grouping of allelic mismatches into permissive and non-permissive categories and their association with transplantation end-points was relevant for trm but not for other clinical end-points.”
Mausfeld, R.. (2010). Intrinsic multiperspectivity: On the architectural foundations of a distinctive mental capacity. In Cognition and Neuropsychology: International Perspectives on Psychological Science
“Sensory systems serve to link the organism to functionally relevant aspects of the physical environment. a mobile organism requires diverse information from the biologi-cal and physical environment and about its internal state for orientation and movement in space and in order to regulate and control its body and behavior. in the course of evolution, with the increased complexity of tasks serv-ing towards orientation and behavioral control there was a growing need to interrelate the diverse sensory chan-nels and also to integrate information about the internal state of the body. this sensory integration required a regulation of awareness to develop which would be able to fi lter the external signals according to internal motiva-tional and emotional states. as sensory systems are cen-tral for behavioral control, the neuronal architecture of sensory systems is intricately interwoven with the motor system. furthermore, evolutionary considerations sug-gest that fundamental features of perception formed the basis for more abstract cognitive achievements and that the underlying general principles are thus also re fl ected in the organization of cognitive processes. for humans, the sensory integratory achievements pertain not only to haptic, visual, auditive, olfactory, and gustatory perception, but also to the perception of the body and its parts [ 6, 27 ] and the relative position of these parts in relation to each other (proprioception) and to their environment, the perception of the viscera (entero-or visceroception), the perception of pain, the perception of physiognomy and body movements and the thus communicated affective expressions and sig-nals, as well as the perception of speech, events, or time. biological species may differently exploit and utilize the physical energies impinging on the organism and organize these energies in the form of sensory modali-ties . by far the largest part of the impinging spatiotempo-ral energy pattern is not processed for biological purposes. only a highly restricted range of this energy pattern is used for the biological function of coupling the organism to its environment (e.g., humans neither can perceive the plain of polarized light nor the direction of the magnetic fi eld). the physical energy is transduced into neural codes in such a way that the particular physical origin of the resulting code is unidenti fi able (e.g., light perception at the eye may originate from optical, mechanical, or electrical stimuli). t…”
Andres, J., & Mausfeld, R.. (2008). Structural description and qualitative content in perception theory. Consciousness and Cognition
“Lustrous surface appearances can be elicited by simple image configurations with no texture or specular highlights, as most prominently illustrated by helmholtz’ demonstration of stereoscopic lustre. three types of explanatory framework have been proposed for stereoscopic lustre, which attribute the phenomenon to a binocular luminance conflict, an internalised physical regularity (helmholtz), or to a disentangling of ‘essential’ and ‘accidental’ attributes in surface representations (hering). in order to investigate these frameworks, we used haploscopically fused half-images of centre-surround configurations in which the luminances of the test patch were dynamically modulated. experiment 1 shows that stereoscopic lustre is not specifically tied to situations of a luminance conflict between the eyes. experiment 2 identifies a novel aspect in the binocular temporal dynamics that provides a physical basis for lustrous appearances, namely the occurrence of a temporal luminance counter-modulation between the eyes. this feature sheds some light on the internal principles underlying a disentangling of ‘accidental’ and ‘essential’ surface attributes. experiment 3 reveals an asymmetry between a light and a dark reference level for the counter-modulations. this finding again suggests an interpretation in terms of an internalised physical regularity with respect to the dynamics of perceiving illuminated surfaces.”